Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview

The matrix metalloproteinases (MMPs) are a family of at least 14 zinc-dependent enzymes which are known to degrade the protein components of extracellular matrix. In adddition, MMPs and related enzymes can also process a number of cell surface cytokines, receptors, and other soluble proteins. In par...

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Bibliographic Details
Published in:	Journal of neuroimmunology Vol. 72; no. 2; pp. 155 - 161
Main Authors:	Chandler, S, Miller, K.M, Clements, J.M, Lury, J, Corkill, D, Anthony, D.C.C, Adams, S.E, Gearing, A.J.H
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-02-1997
Subjects:	Animals Humans Matrix metalloproteinase Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - physiology Multiple sclerosis Multiple Sclerosis - enzymology Multiple Sclerosis - immunology Multiple Sclerosis - pathology Tumor necrosis factor Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - physiology Tumor necrosis factor Multiple sclerosis Matrix metalloproteinase
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Summary:	The matrix metalloproteinases (MMPs) are a family of at least 14 zinc-dependent enzymes which are known to degrade the protein components of extracellular matrix. In adddition, MMPs and related enzymes can also process a number of cell surface cytokines, receptors, and other soluble proteins. In particular we have shown that the release of the pro-inflammatory cytokine, tumor necrosis factor- α, from its membrane-bound precursor is an MMP-dependent process. MMPs are expressed by the inflammatory cells which are associated with CNS lesions in animal models of multiple sclerosis (MS) and in tissue from patients with the disease. MMP expression will contribute to the tissue destruction and inflammation in MS. Drugs which inhibit MMP activity are effective in animal models of MS and may prove to be useful therapies in the clinic.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0165-5728 1872-8421
DOI:	10.1016/S0165-5728(96)00179-8