Search Results - "Anthes, John C"

Identification and characterization of splice variants of the human P2X7 ATP channel by Cheewatrakoolpong, Boonlert, Gilchrest, Helen, Anthes, John C, Greenfeder, Scott

“…The P2X7 channel is a member of the P2X family of ligand-gated ion channels which respond to ATP as the endogenous agonist. Studies suggest that P2X7 has a…”
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Mineralocorticoid receptor antagonists attenuate pulmonary inflammation and bleomycin-evoked fibrosis in rodent models by Lieber, Gissela B, Fernandez, Xiomara, Mingo, Garfield G, Jia, Yanlin, Caniga, Michael, Gil, Malgorzata A., Keshwani, Shanil, Woodhouse, Janice D., Cicmil, Milenko, Moy, Lily Y, Kelly, Nancy, Jimenez, Johanna, Crawley, Yvette, Anthes, John C, Klappenbach, Joel, Ma, Yu-Lu, McLeod, Robbie L.

“…Accumulating evidence indicates protective actions of mineralocorticoid antagonists (MR antagonists) on cardiovascular pathology, which includes blunting…”
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Cloning and pharmacological characterization of mouse TRPV1 by Correll, Craig C., Phelps, P. Tara, Anthes, John C., Umland, Shelby, Greenfeder, Scott

“…The Transient Receptor Potential cation channel V1 (TRPV1) is expressed in peripheral nociceptive neurons and is subject to polymodal activation via various…”
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Biochemical characterization of desloratadine, a potent antagonist of the human histamine H1 receptor by ANTHES, John C, GILCHREST, Helen, EGAN, Robert W, RICHARD, Christian, ECKEL, Stephen, HESK, Dave, WEST, Robert E, WILLIAMS, Shirley M, GREENFEDER, Scott, BILLAH, Motasim, KREUTNER, William

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Cloning and functional characterization of dog transient receptor potential vanilloid receptor-1 (TRPV1) by Phelps, P. Tara, Anthes, John C., Correll, Craig C.

“…Transient receptor potential vanilloid receptor-1 (TRPV1) is a sensory neuron-specific cation channel capable of integrating various noxious chemical and…”
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The Toxicity of SCH 351591, a Novel Phosphodiesterase-4 Inhibitor, in Cynomolgus Monkeys by Losco, Patricia E., Evans, Ellen W., Barat, Stephen A., Blackshear, Pamela E., Reyderman, Larisa, Fine, Jay S., Bober, Loretta A., Anthes, John C., Mirro, Elmer J., Cuss, Francis M.

“…SCH351591, a novel phosphodiesterase-4 inhibitor under investigation as a potential therapeutic for asthma and chronic obstructive pulmonary disease (COPD),…”
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SCH 206272: a potent, orally active tachykinin NK1, NK2, and NK3 receptor antagonist by ANTHES, John C, CHAPMAN, Richard W, RIZZO, Charles, CRAWLEY, Yvette, SHIH, Neng-Yang, PIWINSKI, John, REICHARD, Greg, TING, Pauline, CARRUTHERS, Nick, CUSS, Francis M, BILLAH, Motasim, KREUTNER, William, RICHARD, Christian, EGAN, Robert W, ECKEL, Stephen, CORBOZ, Michel, HEY, John A, FERNANDEZ, Xiomara, GREENFEDER, Scott, MCLEOD, Robbie, SEHRING, Susan

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Synthesis and NK1/NK2 binding activities of a series of diacyl-substituted 2-arylpiperazines by BLYTHIN, David J, XIAO CHEN, PIWINSKI, John J, SHIH, Neng-Yang, SHUE, Ho-Jane, ANTHES, John C, MCPHAIL, Andrew T

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Cloning and characterization of a novel human histamine receptor by Morse, K L, Behan, J, Laz, T M, West, Jr, R E, Greenfeder, S A, Anthes, J C, Umland, S, Wan, Y, Hipkin, R W, Gonsiorek, W, Shin, N, Gustafson, E L, Qiao, X, Wang, S, Hedrick, J A, Greene, J, Bayne, M, Monsma, Jr, F J

“…Histamine exerts its numerous physiological functions through interaction with G protein-coupled receptors. Three such receptors have been defined at both the…”
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TRPV1 Antagonists as Potential Antitussive Agents by McLeod, Robbie L., Correll, Craig C., Jia, Yanlin, Anthes, John C.

“…Cough is an important defensive pulmonary reflex that removes irritants, fluids, or foreign materials from the airways. However, when cough is exceptionally…”
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Tryptase-induced airway microvascular leakage in guinea pigs: involvement of tachykinins and leukotrienes by Greenfeder, Scott, Sehring, Susan, McHugh, Nansie, Corboz, Michel, Rivelli, Maria, Anthes, John C, Billah, Motasim, Egan, Robert W, Chapman, Richard W

“…Tryptase, a serine protease synthesized by and stored in mast cells, is implicated as an important mediator in the pathogenesis of airway inflammation. In this…”
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Effect of mometasone furoate (MF)/formoterol fumarate (F) combination (MF/F) on late-phase responses in allergen-challenged Brown Norway rats by Chapman, Richard W, Curran, Aidan K, House, Aileen, Richard, Jennifer, Salisbury, Brian, Hunter, John C, Anthes, John C, Phillips, Jonathan E

“…Abstract Mometasone furoate (MF)/formoterol fumarate (F) combination is a new inhaIed corticosteroid/long-acting β2 -adrenergic agonist (ICS/LABA). The purpose…”
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Spiro-piperidine azetidinones as potent TRPV1 antagonists by Xiao, Dong, Palani, Anandan, Aslanian, Robert, McKittrick, Brian A., McPhail, Andrew T., Correll, Craig C., Phelps, P. Tara, Anthes, John C., Rindgen, Diane

“…A potent TRPV1 antagonist with good rat pharmacokinetic profile was discovered. A series of spiro-piperidine azetidinone were synthesized and evaluated as…”
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The synthesis and structure-activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists by TING, Pauline C, LEE, Joe F, ANTHES, John C, RIVELLI, Maria A, CORBOZ, Michel R, HEY, John A, ALBANESE, Margaret M, JIE WU, ASLANIAN, Robert, FAVREAU, Leonard, NARDO, Cymbelene, KORFMACHER, Walter A, WEST, Robert E, WILLIAMS, Shirley M

“…A structure-activity relationship study of the lead piperazinylcarbonylpiperidine compound 3 resulted in the identification of…”
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A family of depsi-peptide fungal metabolites, as selective and competitive human tachykinin receptor (NK2) antagonists: fermentation, isolation, physico-chemical properties, and biological activity by Hedge, V R, Puar, M S, Dai, P, Pu, H, Patel, M, Anthes, J C, Richard, C, Terracciano, J, Das, P R, Gullo, V

“…Four tachykinin (NK2) receptor inhibitors, SCH 378161 (1), SCH 217048 (2), SCH 378199 (3), and SCH 378167 (4) were isolated from the fermentation broth of a…”
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Characterization of adenosine receptors in the human bladder carcinoma T24 cell line by Phelps, P. Tara, Anthes, John C., Correll, Craig C.

“…The molecular and pharmacological properties of adenosine receptors in the T24 human bladder epithelial carcinoma cell line were assessed by Reverse…”
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Human cord blood-derived mast cells synthesize and release I-309 in response to IgE by Gilchrest, Helen, Cheewatrakoolpong, Boonlert, Billah, Motasim, Egan, Robert W, Anthes, John C, Greenfeder, Scott

“…Mast cells are the central mediating cells of allergic reactions. Binding of allergen specific IgE to high affinity IgE receptor (FcεRI) and subsequent binding…”
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Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists by BERLIN, Michael, TING, Pauline C, DUGUMA, Luli, SOLOMON, Daniel M, WEI ZHOU, SHER, Rosy, FAVREAU, Leonard, BRYANT, Matthew, KORFMACHER, Walter A, NARDO, Cymbelene, WEST, Robert E, ANTHES, John C, VACCARO, Wayne D, WILLIAMS, Shirley M, WU, Ren-Long, SHE, H. Susan, RIVELLI, Maria A, CORBOZ, Michel R, HEY, John A, ASLANIAN, Robert, MCCORMICK, Kevin D, LEE, Joe F, ALBANESE, Margaret M, MUTAHI, Mwangi W, PIWINSKI, John J, SHIH, Neng-Yang

“…A novel series of histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine template displaying low CYP2D6 and CYP3A4 inhibitory…”
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New asthma targets: recent clinical and preclinical advances by Greenfeder, Scott, Anthes, John C

“…Current asthma therapy is directed at the relief of chronic inflammation or improving lung function through bronchodilation. These approaches treat the overt…”
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Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold by VACCARO, Wayne D, SHER, Rosy, WILLIAMS, Shirley M, WU, Ren-Long, SHE, H. Susan, RIVELLI, Maria A, MUTTER, Jennifer C, CORBOZ, Michel R, HEY, John A, FAVREAU, Leonard, BERLIN, Michael, SHIH, Neng-Yang, ASLANIAN, Robert, SCHWERDT, John H, MCCORMICK, Kevin D, PIWINSKI, John J, WEST, Robert E, ANTHES, John C

“…We report the discovery of novel histamine H(3) receptor antagonists based on 4-[(1H-imidazol-4-yl)methyl]piperidine. The most potent compounds in the series…”
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