Search Results - "Antel, Jack P."

Roles of microglia in brain development, tissue maintenance and repair by Michell-Robinson, Mackenzie A, Touil, Hanane, Healy, Luke M, Owen, David R, Durafourt, Bryce A, Bar-Or, Amit, Antel, Jack P, Moore, Craig S

“…The emerging roles of microglia are currently being investigated in the healthy and diseased brain with a growing interest in their diverse functions. In…”
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Cells of the oligodendroglial lineage, myelination, and remyelination by Miron, Veronique E., Kuhlmann, Tanja, Antel, Jack P.

“…Myelin is critical in maintaining electrical impulse conduction in the central nervous system. The oligodendrocyte is the cell type responsible for myelin…”
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iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases by Abud, Edsel M., Ramirez, Ricardo N., Martinez, Eric S., Healy, Luke M., Nguyen, Cecilia H.H., Newman, Sean A., Yeromin, Andriy V., Scarfone, Vanessa M., Marsh, Samuel E., Fimbres, Cristhian, Caraway, Chad A., Fote, Gianna M., Madany, Abdullah M., Agrawal, Anshu, Kayed, Rakez, Gylys, Karen H., Cahalan, Michael D., Cummings, Brian J., Antel, Jack P., Mortazavi, Ali, Carson, Monica J., Poon, Wayne W., Blurton-Jones, Mathew

“…Microglia play critical roles in brain development, homeostasis, and neurological disorders. Here, we report that human microglial-like cells (iMGLs) can be…”
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Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation by Mayo, Lior, Trauger, Sunia A, Blain, Manon, Nadeau, Meghan, Patel, Bonny, Alvarez, Jorge I, Mascanfroni, Ivan D, Yeste, Ada, Kivisäkk, Pia, Kallas, Keith, Ellezam, Benjamin, Bakshi, Rohit, Prat, Alexandre, Antel, Jack P, Weiner, Howard L, Quintana, Francisco J

“…In multiple sclerosis and experimental autoimmune encephalomyelitis, astrocytes produce lactosylceramide, a glycolipid that promotes astrocyte and microglial…”
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Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS by Chao, Chun-Cheih, Gutiérrez-Vázquez, Cristina, Rothhammer, Veit, Mayo, Lior, Wheeler, Michael A., Tjon, Emily C., Zandee, Stephanie E.J., Blain, Manon, de Lima, Kalil Alves, Takenaka, Maisa C., Avila-Pacheco, Julian, Hewson, Patrick, Liu, Lei, Sanmarco, Liliana M., Borucki, Davis M., Lipof, Gabriel Z., Trauger, Sunia A., Clish, Clary B., Antel, Jack P., Prat, Alexandre, Quintana, Francisco J.

“…Metabolism has been shown to control peripheral immunity, but little is known about its role in central nervous system (CNS) inflammation. Through a…”
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Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury by Greenhalgh, Andrew D, Zarruk, Juan G, Healy, Luke M, Baskar Jesudasan, Sam J, Jhelum, Priya, Salmon, Christopher K, Formanek, Albert, Russo, Matthew V, Antel, Jack P, McGavern, Dorian B, McColl, Barry W, David, Samuel

“…Infiltrating monocyte-derived macrophages (MDMs) and resident microglia dominate central nervous system (CNS) injury sites. Differential roles for these cell…”
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Seeking neuroprotection in multiple sclerosis: an ongoing challenge by Antel, Jack P, Kennedy, Timothy E, Kuhlmann, Tanja

“…Multiple sclerosis (MS) is an autoimmune disease of the CNS, featuring inflammation and demyelination with variable recovery. In this issue of the JCI, Kapell,…”
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A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response by Haenseler, Walther, Sansom, Stephen N., Buchrieser, Julian, Newey, Sarah E., Moore, Craig S., Nicholls, Francesca J., Chintawar, Satyan, Schnell, Christian, Antel, Jack P., Allen, Nicholas D., Cader, M. Zameel, Wade-Martins, Richard, James, William S., Cowley, Sally A.

“…Microglia are increasingly implicated in brain pathology, particularly neurodegenerative disease, with many genes implicated in Alzheimer's, Parkinson's, and…”
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Comparison of polarization properties of human adult microglia and blood-derived macrophages by Durafourt, Bryce A., Moore, Craig S., Zammit, Domenick A., Johnson, Trina A., Zaguia, Fatma, Guiot, Marie-Christine, Bar-Or, Amit, Antel, Jack P.

“…Both microglia, the resident myeloid cells of the CNS parenchyma, and infiltrating blood‐derived macrophages participate in inflammatory responses in the CNS…”
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Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation by Wheeler, Michael A., Jaronen, Merja, Covacu, Ruxandra, Zandee, Stephanie E.J., Scalisi, Giulia, Rothhammer, Veit, Tjon, Emily C., Chao, Chun-Cheih, Kenison, Jessica E., Blain, Manon, Rao, Vijayaraghava T.S., Hewson, Patrick, Barroso, Andreia, Gutiérrez-Vázquez, Cristina, Prat, Alexandre, Antel, Jack P., Hauser, Russ, Quintana, Francisco J.

“…Genome-wide studies have identified genetic variants linked to neurologic diseases. Environmental factors also play important roles, but no methods are…”
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MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells by Healy, Luke M, Perron, Gabrielle, Won, So-Yoon, Michell-Robinson, Mackenzie A, Rezk, Ayman, Ludwin, Samuel K, Moore, Craig S, Hall, Jeffery A, Bar-Or, Amit, Antel, Jack P

“…Multifocal inflammatory lesions featuring destruction of lipid-rich myelin are pathologic hallmarks of multiple sclerosis. Lesion activity is assessed by the…”
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miR-155 as a multiple sclerosis-relevant regulator of myeloid cell polarization by Moore, Craig S., Rao, Vijayaraghava T.S., Durafourt, Bryce A., Bedell, Barry J., Ludwin, Samuel K., Bar-Or, Amit, Antel, Jack P.

“…Objective To define the functional significance of increased miR‐155 expression in myeloid cells in multiple sclerosis (MS). Methods miR‐155 expression levels…”
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Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica by Bennett, Jeffrey L., Lam, Chiwah, Kalluri, Sudhakar Reddy, Saikali, Philippe, Bautista, Katherine, Dupree, Cecily, Glogowska, Magdalena, Case, David, Antel, Jack P., Owens, Gregory P., Gilden, Don, Nessler, Stefan, Stadelmann, Christine, Hemmer, Bernhard

“…Objective The serum of most neuromyelitis optica (NMO) patients contains autoantibodies (NMO‐IgGs) directed against the aquaporin‐4 (AQP4) water channel…”
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Oligodendrogliopathy in Multiple Sclerosis: Low Glycolytic Metabolic Rate Promotes Oligodendrocyte Survival by Rone, Malena B, Cui, Qiao-Ling, Fang, Jun, Wang, Li-Chun, Zhang, Ji, Khan, Damla, Bedard, Melissa, Almazan, Guillermina, Ludwin, Samuel K, Jones, Russel, Kennedy, Timothy E, Antel, Jack P

“…Multiple sclerosis (MS) lesions feature demyelination with limited remyelination. A distinct injury phenotype of MS lesions features dying back of…”
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Astrocytes in multiple sclerosis by Ludwin, Samuel K, Rao, Vijayaraghava TS, Moore, Craig S, Antel, Jack P

“…Recent experimental and clinical studies on astrocytes are unraveling the capabilities of these multi-functional cells in normal homeostasis, and in central…”
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Peripheral nerve injury induces persistent vascular dysfunction and endoneurial hypoxia, contributing to the genesis of neuropathic pain by Lim, Tony K Y, Shi, Xiang Q, Johnson, Julia M, Rone, Malena B, Antel, Jack P, David, Samuel, Zhang, Ji

“…Nerve injury is associated with microvascular disturbance; however, the role of the vascular system has not been well characterized in the context of…”
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Sphingosine-1-Phosphate Receptors in the Central Nervous and Immune Systems by Healy, Luke M, Antel, Jack P

“…Sphingosine-1-phosphate receptor (S1PR) modulators have entered clinical practice as immune-modulators for the treatment of multiple sclerosis (MS)…”
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Systematic comparison of culture media uncovers phenotypic shift of primary human microglia defined by reduced reliance to CSF1R signaling by Dorion, Marie‐France, Yaqubi, Moein, Murdoch, Hunter J., Hall, Jeffery A., Dudley, Roy, Antel, Jack P., Durcan, Thomas Martin, Healy, Luke Michael

“…Efforts to understand microglia function in health and diseases have been hindered by the lack of culture models that recapitulate in situ cellular properties…”
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Direct and indirect effects of immune and central nervous system-resident cells on human oligodendrocyte progenitor cell differentiation by Moore, Craig S, Cui, Qiao-Ling, Warsi, Nebras M, Durafourt, Bryce A, Zorko, Nika, Owen, David R, Antel, Jack P, Bar-Or, Amit

“…In multiple sclerosis, successful remyelination within the injured CNS is largely dependent on the survival and differentiation of oligodendrocyte progenitor…”
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Functional Consequences of Neuromyelitis Optica-IgG Astrocyte Interactions on Blood-Brain Barrier Permeability and Granulocyte Recruitment by Vincent, Thierry, Saikali, Philippe, Cayrol, Romain, Roth, Alejandro D, Bar-Or, Amit, Prat, Alexandre, Antel, Jack P

“…Autoantibody neuromyelitis optica-IgG (NMO-IgG) recognizing aquaporin-4 (AQP4) is implicated as playing a central role in the physiopathology of NMO. The aim…”
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