Search Results - "Antel, JP"

Identification of a unique TGF-β–dependent molecular and functional signature in microglia by Butovsky, Oleg, Jedrychowski, Mark P, Moore, Craig S, Cialic, Ron, Lanser, Amanda J, Gabriely, Galina, Koeglsperger, Thomas, Dake, Ben, Wu, Pauline M, Doykan, Camille E, Fanek, Zain, Liu, LiPing, Chen, Zhuoxun, Rothstein, Jeffrey D, Ransohoff, Richard M, Gygi, Steven P, Antel, Jack P, Weiner, Howard L

“…Microglia are resident myeloid cells of the central nervous system integral for neuroprotective and neurodegenerative processes. Here the authors describe a…”
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Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation by Wheeler, Michael A., Jaronen, Merja, Covacu, Ruxandra, Zandee, Stephanie E.J., Scalisi, Giulia, Rothhammer, Veit, Tjon, Emily C., Chao, Chun-Cheih, Kenison, Jessica E., Blain, Manon, Rao, Vijayaraghava T.S., Hewson, Patrick, Barroso, Andreia, Gutiérrez-Vázquez, Cristina, Prat, Alexandre, Antel, Jack P., Hauser, Russ, Quintana, Francisco J.

“…Genome-wide studies have identified genetic variants linked to neurologic diseases. Environmental factors also play important roles, but no methods are…”
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T follicular helper cells in human efferent lymph retain lymphoid characteristics by Vella, Laura A, Buggert, Marcus, Manne, Sasikanth, Herati, Ramin S, Sayin, Ismail, Kuri-Cervantes, Leticia, Bukh Brody, Irene, O'Boyle, Kaitlin C, Kaprielian, Hagop, Giles, Josephine R, Nguyen, Son, Muselman, Alexander, Antel, Jack P, Bar-Or, Amit, Johnson, Matthew E, Canaday, David H, Naji, Ali, Ganusov, Vitaly V, Laufer, Terri M, Wells, Andrew D, Dori, Yoav, Itkin, Maxim G, Betts, Michael R, Wherry, E John

“…T follicular helper cells (Tfh), a subset of CD4+ T cells, provide requisite help to B cells in the germinal centers (GC) of lymphoid tissue. GC Tfh are…”
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TLR Signaling Tailors Innate Immune Responses in Human Microglia and Astrocytes by Jack, Carolyn S, Arbour, Nathalie, Manusow, Joshua, Montgrain, Vivianne, Blain, Manon, McCrea, Ellie, Shapiro, Aaron, Antel, Jack P

“…The specific signals mediating the activation of microglia and astrocytes as a prelude to, or consequence of, CNS inflammation continue to be defined. We…”
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Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury by D'Souza, S, Alinauskas, K, McCrea, E, Goodyer, C, Antel, JP

“…We examined whether oligodendrocytes, neurons, and astroglia derived from the human central nervous system differ in susceptibility to injury mediated by tumor…”
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Microglia and multiple sclerosis by Jack, Carolyn, Ruffini, Francesca, Bar-Or, Amit, Antel, Jack P.

“…Microglia participate in all phases of the multiple sclerosis (MS) disease process. As members of the innate immune system, these cells have evolved to respond…”
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Neuroleukin: A Lymphokine Product of Lectin-Stimulated T Cells by Gurney, Mark E., Apatoff, Brian R., Spear, Gregory T., Baumel, Mark J., Antel, Jack P., Bania, Margaret Brown, Reder, Anthony T.

“…Neuroleukin is a lymphokine product of lectin-stimulated T cells that induces immunoglobulin secretion by cultured human peripheral blood mononuclear cells…”
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Natalizumab effects on immune cell responses in multiple sclerosis by Niino, Masaaki, Bodner, Caroline, Simard, Marie-Lune, Alatab, Sudabeh, Gano, Dawn, Kim, Ho Jin, Trigueiro, Manuela, Racicot, Denise, Guérette, Christine, Antel, Jack P., Fournier, Alyson, Grand'Maison, Francois, Bar-Or, Amit

“…Objective Our objective was to study in vivo biological effects of natalizumab on immune cell phenotype and function in multiple sclerosis (MS) patients…”
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Type 2 Monocyte and Microglia Differentiation Mediated by Glatiramer Acetate Therapy in Patients with Multiple Sclerosis by Kim, Ho Jin, Ifergan, Igal, Antel, Jack P, Seguin, Rosanne, Duddy, Martin, Lapierre, Yves, Jalili, Farzaneh, Bar-Or, Amit

“…Glatiramer acetate (GA) therapy of patients with multiple sclerosis (MS) represents a unique setting in which in vivo Th2 deviation of T cells is consistently…”
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Vulnerability of Human Neurons to T Cell-Mediated Cytotoxicity by Giuliani, Fabrizio, Goodyer, Cynthia G, Antel, Jack P, Yong, V. Wee

“…Axonal and neuronal loss occurs in inflammatory diseases of the CNS such as multiple sclerosis. The cause of the loss remains unclear. We report that…”
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Glial cell influence on the human blood-brain barrier by Prat, Alexandre, Biernacki, Katarzyna, Wosik, Karolina, Antel, Jack P.

“…The blood‐brain barrier (BBB) is a specialized structure of the central nervous system (CNS) that restricts immune cell migration and soluble molecule…”
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Inositol Stereoisomers Stabilize an Oligomeric Aggregate of Alzheimer Amyloid β Peptide and Inhibit Aβ-induced Toxicity by McLaurin, JoAnne, Golomb, Rivka, Jurewicz, Anna, Antel, Jack P., Fraser, Paul E.

“…Inositol has 8 stereoisomers, four of which are physiologically active. myo-Inositol is the most abundant isomer in the brain and more recently shown that epi-…”
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Minocycline reduces gadolinium-enhancing magnetic resonance imaging lesions in multiple sclerosis by Metz, Luanne M., Zhang, Yunyan, Yeung, Michael, Patry, David G., Bell, Robert B., Stoian, Cristina A., Yong, V. Wee, Patten, Scott B., Duquette, Pierre, Antel, Jack P., Mitchell, J. Ross

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Development of a multiple sclerosis functional composite as a clinical trial outcome measure by Cutter, Gary R., Baier, Monika L., Rudick, Richard A., Cookfair, Diane L., Fischer, Jill S., Petkau, John, Syndulko, Karl, Weinshenker, Brian G., Antel, Jack P., Confavreux, Christian, Ellison, George W., Lublin, Fred, Miller, Aaron E., Rao, Stephen M., Reingold, Stephen, Thompson, Alan, Willoughby, Ernest

“…The primary clinical outcome measure for evaluating multiple sclerosis in clinical trials has been Kurtzke's expanded disability status scale (EDSS). New…”
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Determinants of Human B Cell Migration Across Brain Endothelial Cells by Alter, Andrea, Duddy, Martin, Hebert, Sherry, Biernacki, Katarzyna, Prat, Alexandre, Antel, Jack P, Yong, Voon Wee, Nuttall, Robert K, Pennington, Caroline J, Edwards, Dylan R, Bar-Or, Amit

“…Circulating B cells enter the CNS as part of normal immune surveillance and in pathologic states, including the common and disabling illness multiple…”
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Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis : Results of a longitudinal magnetic resonance spectroscopy study by DE STEFANO, N, MATTHEWS, P. M, FU, L, NARAYANAN, S, STANLEY, J, FRANCIS, G. S, ANTEL, J. P, ARNOLD, D. L

“…It has been difficult to establish a strong correlation between total brain T2-weighted lesion volume on MRI and clinical disability in multiple sclerosis, in…”
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Interferon beta-1b decreases the migration of T lymphocytes in vitro: effects on matrix metalloproteinase-9 by Stüve, O, Dooley, N P, Uhm, J H, Antel, J P, Francis, G S, Williams, G, Yong, V W

“…In multiple sclerosis (MS), the influx of activated T lymphocytes into the brain parenchyma leads to the subsequent damage of oligodendrocytes, the cells that…”
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Imaging axonal damage of normal-appearing white matter in multiple sclerosis by FU, L, MATTHEWS, P. M, DE STEFANO, N, WORSLEY, K. J, NARAYANAN, S, FRANCIS, G. S, ANTEL, J. P, WOLFSON, C, ARNOLD, D. L

“…The current study was designed to determine the relative distribution of decreases of N-acetylasparate (NAA), a marker of axonal damage, between lesions and…”
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Distinctive Properties of Human Adult Brain-Derived Myelin Progenitor Cells by Ruffini, Francesca, Arbour, Nathalie, Blain, Manon, Olivier, André, Antel, Jack P.

“…We used expression of the ganglioside A2B5 to isolate putative myelin progenitor cells from adult human central nervous system parenchyma and compared their…”
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Resistance of human adult oligodendrocytes to AMPA/kainate receptor-mediated glutamate injury by Wosik, Karolina, Ruffini, Francesca, Almazan, Guillermina, Olivier, André, Nalbantoglu, Josephine, Antel, Jack P.

“…Multiple sclerosis is an inflammatory disease of the CNS leading to the destruction of oligodendrocytes (OLs), myelin sheaths and axons. The mediators of…”
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