Search Results - "Anson, Blake D."

High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents by Ma, Junyi, Guo, Liang, Fiene, Steve J, Anson, Blake D, Thomson, James A, Kamp, Timothy J, Kolaja, Kyle L, Swanson, Bradley J, January, Craig T

“…Human-induced pluripotent stem cells (hiPSCs) can differentiate into functional cardiomyocytes; however, the electrophysiological properties of hiPSC-derived…”
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Development and Characterization of a Scaffold-Free 3D Spheroid Model of Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes by Beauchamp, Philippe, Moritz, Wolfgang, Kelm, Jens M, Ullrich, Nina D, Agarkova, Irina, Anson, Blake D, Suter, Thomas M, Zuppinger, Christian

“…Cardiomyocytes (CMs) are terminally differentiated cells in the adult heart, and ischemia and cardiotoxic compounds can lead to cell death and irreversible…”
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Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism by ANDERSON, Corey L, DELISLE, Brian P, ANSON, Blake D, KILBY, Jennifer A, WILL, Melissa L, TESTER, David J, QIUMING GONG, ZHENGFENG ZHOU, ACKERMAN, Michael J, JANUARY, Craig T

“…The KCNH2 or human ether-a-go-go related gene (hERG) encodes the Kv11.1 alpha-subunit of the rapidly activating delayed rectifier K+ current (IKr) in the…”
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Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels by Anson, Blake D, Ackerman, Michael J, Tester, David J, Will, Melissa L, Delisle, Brian P, Anderson, Corey L, January, Craig T

“…Long QT syndrome (LQTS) is a cardiac repolarization disorder that can lead to arrhythmias and sudden death. Chromosome 7-linked inherited LQTS (LQT2) is caused…”
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Thapsigargin Selectively Rescues the Trafficking Defective LQT2 Channels G601S and F805C by Delisle, Brian P., Anderson, Corey L., Balijepalli, Ravi C., Anson, Blake D., Kamp, Timothy J., January, Craig T.

“…Several mutations in the human ether-a-go-go-related K+ channel gene (HERG or KCNH2) cause long QT syndrome (LQT2) by reducing the intracellular transport…”
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Properties of WT and mutant hERG K(+) channels expressed in neonatal mouse cardiomyocytes by Lin, Eric C, Holzem, Katherine M, Anson, Blake D, Moungey, Brooke M, Balijepalli, Sadguna Y, Tester, David J, Ackerman, Michael J, Delisle, Brian P, Balijepalli, Ravi C, January, Craig T

“…Mutations in human ether-a-go-go-related gene 1 (hERG) are linked to long QT syndrome type 2 (LQT2). hERG encodes the pore-forming alpha-subunits that…”
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Identification of Drug-Drug Interactions In Vitro: A Case Study Evaluating the Effects of Sofosbuvir and Amiodarone on hiPSC-Derived Cardiomyocytes by Millard, Daniel C, Strock, Christopher J, Carlson, Coby B, Aoyama, Natsuyo, Juhasz, Krisztina, Goetze, Tom A, Stoelzle-Feix, Sonja, Becker, Nadine, Fertig, Niels, January, Craig T, Anson, Blake D, Ross, James D

“…Drug-drug interactions pose a difficult drug safety problem, given the increasing number of individuals taking multiple medications and the relative complexity…”
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Biology of Cardiac Arrhythmias: Ion Channel Protein Trafficking by Delisle, Brian P, Anson, Blake D, Rajamani, Sridharan, January, Craig T, Marbán, Eduardo, Tomaselli, Gordon

“…The mechanisms underlying normal and abnormal cardiac rhythms are complex and incompletely understood. Through the study of uncommon inheritable arrhythmia…”
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Intragenic suppression of trafficking-defective KCNH2 channels associated with long QT syndrome by Delisle, Brian P, Slind, Jessica K, Kilby, Jennifer A, Anderson, Corey L, Anson, Blake D, Balijepalli, Ravi C, Tester, David J, Ackerman, Michael J, Kamp, Timothy J, January, Craig T

“…Mutations in the KCNH2 or human ether-a-go-go-related gene-encoded K(+) channel reduce functional KCNH2 current (I(KCNH2)) to cause long QT syndrome (LQT2) by…”
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Evaluating the use of microelectrode array technology and cell-based neuronal culture models for proconvulsant risk assessment: progress from the HESI NeuTox consortium by Millard, Daniel C., Nicolini, Anthony M., Arrowood, Colin A., Hayes, Heather B., Bradley, Jenifer A., Strock, Christopher J., Freudenrich, Theresa M., Wallace, Kathleen, Shafer, Timothy J., Cato, Matthew J., Chaudhary, Khuram W., Saavedra, Lorena, Haag, Daniel, Feaster, T.K., Anson, Blake D., Luerman, Greg, Hess, Dietmar, Shi, Yichen, Li, Jinqing, Shi, Hong, Levesque, Paul, Kreir, Mohamed, Lu, Hua Rong, Suzuki, Ikuro, Odawara, Aoi, Miyamoto, Norimasa, Ojima, Atsuko, Kanda, Yasunari, Blinova, Ksenia, Herr, David, Roberts, Ruth, Pierson, Jennifer

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Stem Cells and Their Derivatives: A Renaissance in Cardiovascular Translational Research by Kattman, Steven J., Koonce, Chad H., Swanson, Bradley J., Anson, Blake D.

“…Moving from the bench to the bedside is an expensive and arduous journey with a high risk of failure. One roadblock on the path of translational medicine is…”
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Pharmacological rescue of human K+ channel long-QT2 mutations: Human ether-a-go-go-related gene rescue without block by RAJAMANI, Sridharan, ANDERSON, Corey L, ANSON, Blake D, JANUARY, Craig T

“…Defective protein trafficking is a consequence of gene mutations. Human long-QT (LQT) syndrome results from mutations in several genes, including the human…”
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Comparison of HERG channel blocking effects of various β‐blockers – implication for clinical strategy by Kawakami, Kazunobu, Nagatomo, Toshihisa, Abe, Haruhiko, Kikuchi, Kan, Takemasa, Hiroko, Anson, Blake D, Delisle, Brian P, January, Craig T, Nakashima, Yasuhide

“…β‐Blockers are widely used in the treatment of cardiovascular diseases. However, their effects on HERG channels at comparable conditions remain to be defined…”
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An intronic mutation causes long QT syndrome by Zhang, Li, Vincent, G. Michael, Baralle, Marco, Baralle, Francisco E., Anson, Blake D., Benson, D. Woodrow, Whiting, Bryant, Timothy, Katherine W., Carlquist, John, January, Craig T., Keating, Mark T., Splawski, Igor

“…The purpose of this research was to determine whether an intronic variant (T1945+6C) in KCNH2is a disease-causing mutation, and if expanded phenotyping…”
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Molecular autopsy for HERG defects in sudden infant death syndrome by Ackerman, Michael J., Anson, Blake D., Tester, David J., Towbin, Jeffrey A., Sturner, William Q., January, Craig T.

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Development of a 3D-spheroid culture system to assess drug induced liver injury using induced pluripotent stem cell-derived hepatocytes by Hancock, Michael, Feaster, T.K., Carlson, Coby, Aoyama, Natsuyo, Schlesinger, David, Mann, David, Anson, Blake D.

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Multiparametric assessment of networked electrical activity using induced pluripotent stem cell-derived glutamatergic neurons by Kim, Kwi Hye, Carlson, Coby, Kannemeier, Christian, Feaster, T.K., Swanson, Brad, Schlesinger, David, Anson, Blake D., Mangan, Kile P.

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Genetic basis for the origin of cardiac arrhythmias: implications for therapy by Mbai, Mackenzi, Rajamani, Sridharan, Delisle, Brian P, Anson, Blake D, Anderson, Corey, Makielski, Jonathan C, January, Craig T

“…The recognition of the role that genetic abnormalities play in the generation of cardiac arrhythmias and sudden cardiac death has evolved enormously over the…”
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Blockade of HERG channels by HIV protease inhibitors by ANSON, B, WEAVER, J, ACKERMAN, M, AKINSETE, O, HENRY, K, JANUARY, C, BADLEY, A

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Opportunities for Human iPS Cells in Predictive Toxicology by Anson, Blake D., Kolaja, Kyle, Kamp, Timothy J.

“…Toxicity assessment is a major challenge for cost-effective drug development, and there is great need for better tools to accurately predict adverse drug…”
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