Search Results - "Anseth, Kristi S."

Spatiotemporal hydrogel biomaterials for regenerative medicine by Brown, Tobin E, Anseth, Kristi S

“…Hydrogels mimic many of the physical properties of soft tissue and are widely used biomaterials for tissue engineering and regenerative medicine. Synthetic…”
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Mechanical memory and dosing influence stem cell fate by Yang, Chun, Tibbitt, Mark W., Basta, Lena, Anseth, Kristi S.

“…We investigated whether stem cells remember past physical signals and whether these can be exploited to dose cells mechanically. We found that the activation…”
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Hydrogels as extracellular matrix mimics for 3D cell culture by Tibbitt, Mark W, Anseth, Kristi S

“…Methods for culturing mammalian cells ex vivo are increasingly needed to study cell and tissue physiology and to grow replacement tissue for regenerative…”
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Nuclear mechanosensing controls MSC osteogenic potential through HDAC epigenetic remodeling by Killaars, Anouk R., Walker, Cierra J., Anseth, Kristi S.

“…Cells sense mechanical cues from the extracellular matrix to regulate cellular behavior and maintain tissue homeostasis. The nucleus has been implicated as a…”
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Synthetic Mimics of the Extracellular Matrix: How Simple is Complex Enough? by Kyburz, Kyle A., Anseth, Kristi S.

“…Cells reside in a complex and dynamic extracellular matrix where they interact with a myriad of biophysical and biochemical cues that direct their function and…”
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Wavelength-Controlled Photocleavage for the Orthogonal and Sequential Release of Multiple Proteins by Azagarsamy, Malar A., Anseth, Kristi S.

“…On the right wavelength: Photolabile molecular units that undergo photocleavage under light of different wavelengths can be used for the independent release of…”
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Measuring dynamic cell–material interactions and remodeling during 3D human mesenchymal stem cell migration in hydrogels by Schultz, Kelly M., Kyburz, Kyle A., Anseth, Kristi S.

“…Biomaterials that mimic aspects of the extracellular matrix by presenting a 3D microenvironment that cells can locally degrade and remodel are finding…”
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Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments by Anseth, Kristi S, DeForest, Cole A, Polizzotti, Brian D

“…Click chemistry provides extremely selective and orthogonal reactions that proceed with high efficiency and under a variety of mild conditions, the most common…”
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Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties by Kloxin, April M, Kasko, Andrea M, Salinas, Chelsea N, Anseth, Kristi S

“…We report a strategy to create photodegradable poly(ethylene glycol)-based hydrogels through rapid polymerization of cytocompatible macromers for remote…”
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Spatially patterned matrix elasticity directs stem cell fate by Yang, Chun, DelRio, Frank W., Ma, Hao, Killaars, Anouk R., Basta, Lena P., Kyburz, Kyle A., Anseth, Kristi S.

“…There is a growing appreciation for the functional role of matrix mechanics in regulating stem cell self-renewal and differentiation processes. However, it is…”
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Bioorthogonal Click Chemistry: An Indispensable Tool to Create Multifaceted Cell Culture Scaffolds by Azagarsamy, Malar A, Anseth, Kristi S

“…Over the past decade, bioorthogonal click chemistry has led the field of biomaterial science into a new era of diversity and complexity by its extremely…”
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Progress in material design for biomedical applications by Tibbitt, Mark W, Christopher B. Rodell, Jason A. Burdick, Kristi S. Anseth

“…Biomaterials that interface with biological systems are used to deliver drugs safely and efficiently; to prevent, detect, and treat disease; to assist the body…”
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Advances in Bioactive Hydrogels to Probe and Direct Cell Fate by DeForest, Cole A, Anseth, Kristi S

“…Advanced cell culture techniques are increasingly needed to better understand basic cell physiology, predict in vivo response, and engineer de novo functional…”
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Photoresponsive Elastic Properties of Azobenzene-Containing Poly(ethylene-glycol)-Based Hydrogels by Rosales, Adrianne M, Mabry, Kelly M, Nehls, Eric Michael, Anseth, Kristi S

“…The elastic modulus of the extracellular matrix is a dynamic property that changes during various biological processes, such as disease progression or wound…”
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Dynamic microenvironments: the fourth dimension by Tibbitt, Mark W, Anseth, Kristi S

“…The extracellular space, or cell microenvironment, choreographs cell behavior through myriad controlled signals, and aberrant cues can result in dysfunction…”
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Synthetically Tractable Click Hydrogels for Three-Dimensional Cell Culture Formed Using Tetrazine–Norbornene Chemistry by Alge, Daniel L, Azagarsamy, Malar A, Donohue, Dillon F, Anseth, Kristi S

“…The implementation of bio-orthogonal click chemistries is a topic of growing importance in the field of biomaterials, as it is enabling the development of…”
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Photo-Click Living Strategy for Controlled, Reversible Exchange of Biochemical Ligands by Gandavarapu, Navakanth R., Azagarsamy, Malar A., Anseth, Kristi S.

“…A novel addition‐fragmentation‐chain transfer capable allyl sulfide functionalized PEG hydrogel is reported to allow controlled, reversible exchange of…”
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Cell-cell communication mimicry with poly(ethylene glycol) hydrogels for enhancing β-cell function by Lin, Chien-Chi, Anseth, Kristi S., Langer, Robert

“…A biomimetic hydrogel platform was designed to signal encapsulated cells using immobilized cell-cell communication cues, with a focus on enhancing the survival…”
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Synthesis of photodegradable hydrogels as dynamically tunable cell culture platforms by Anseth, Kristi S, Kloxin, April M, Tibbitt, Mark W

“…We describe a detailed procedure to create photolabile, polyethylene glycol (PEG)-based hydrogels and manipulate material properties in situ . The…”
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Three-dimensional hMSC motility within peptide-functionalized PEG-based hydrogels of varying adhesivity and crosslinking density by Kyburz, Kyle A., Anseth, Kristi S.

“…Human mesenchymal stem cell (hMSC) migration and recruitment play a critical role during bone fracture healing. Within the complex three-dimensional (3-D) in…”
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