Search Results - "Ansell, Jack"

Direct thrombin inhibitors by Lee, Catherine J., Ansell, Jack E.

“…Heparins and vitamin K antagonists have been the primary agents used for anticoagulation in certain cardiovascular and thromboembolic diseases for over 50…”
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Use of PER977 to Reverse the Anticoagulant Effect of Edoxaban by Ansell, Jack E, Bakhru, Sasha H, Laulicht, Bryan E, Steiner, Solomon S, Grosso, Michael, Brown, Karen, Dishy, Victor, Noveck, Robert J, Costin, James C

“…Among 80 healthy persons who had received a single dose of edoxaban, the whole-blood clotting time was reduced significantly more rapidly in those who received…”
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The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation by O'Brien, Emily C, Simon, DaJuanicia N, Thomas, Laine E, Hylek, Elaine M, Gersh, Bernard J, Ansell, Jack E, Kowey, Peter R, Mahaffey, Kenneth W, Chang, Paul, Fonarow, Gregg C, Pencina, Michael J, Piccini, Jonathan P, Peterson, Eric D

“…Therapeutic decisions in atrial fibrillation (AF) are often influenced by assessment of bleeding risk. However, existing bleeding risk scores have limitations…”
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Stroke Prevention in Atrial Fibrillation in the Very Elderly: Anticoagulant Therapy Is No Longer a Sin by Ansell, Jack

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Universal, class-specific and drug-specific reversal agents for the new oral anticoagulants by Ansell, Jack E.

“…Although there is controversy about the absolute need for a reversal agent for the new direct oral anticoagulants (DOACs), the absence of such an agent is a…”
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Warfarin versus new agents: interpreting the data by Ansell, Jack

“…Stroke prevention in atrial fibrillation (AF) is a rapidly expanding indication for lifelong oral anticoagulation. The vitamin K antagonists (VKAs) effectively…”
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Indirect comparison of dabigatran, rivaroxaban, apixaban and edoxaban for the treatment of acute venous thromboembolism by Mantha, Simon, Ansell, Jack

“…Four target-specific oral anticoagulants (TSOA’s) have been compared to a vitamin K antagonist for the treatment of acute venous thromboembolism (VTE):…”
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Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban by Ansell, Jack E, Bakhru, Sasha H, Laulicht, Bryan E, Steiner, Solomon S, Grosso, Michael A, Brown, Karen, Dishy, Victor, Lanz, Hans J, Mercuri, Michele F, Noveck, Robert J, Costin, James C

“…Of the new direct oral anticoagulants, direct factor Xa inhibitors are limited by the absence of a proven reversal agent. We assessed the safety, tolerability…”
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Self-monitoring of oral anticoagulation: systematic review and meta-analysis of individual patient data by Heneghan, Carl, Dr, Ward, Alison, PhD, Perera, Rafael, DPhil, Bankhead, Clare, DPhil, Fuller, Alice, BSc, Stevens, Richard, PhD, Bradford, Kairen, MA, Tyndel, Sally, PhD, Alonso-Coello, Pablo, PhD, Ansell, Jack, Prof, Beyth, Rebecca, MD, Bernardo, Artur, MD, Christensen, Thomas Decker, DMSc, Cromheecke, Manon, PhD, Edson, Robert G, MA, Fitzmaurice, David, Prof, Gadisseur, Alain PA, PhD, Garcia-Alamino, Josep M, RN, Gardiner, Chris, PhD, Hasenkam, Michael, Prof, Jacobson, Alan, MD, Kaatz, Scott, DO, Kamali, Farhad, Prof, Khan, Tayyaba Irfan, PhD, Knight, Eve, DipHPsych, Körtke, Heinrich, PhD, Levi, Marcel, PhD, Matchar, David Bruce, Prof, Menéndez-Jándula, Bárbara, MD, Rakovac, Ivo, PhD, Schaefer, Christian, Siebenhofer, Andrea, Prof, Souto, Juan Carlos, PhD, Sunderji, Rubina, Prof, Gin, Kenneth, Prof, Shalansky, Karen, Prof, Völler, Heinz, Prof, Wagner, Otto, MSc, Zittermann, Armin, Prof

“…Summary Background Uptake of self-testing and self-management of oral anticoagulation has remained inconsistent, despite good evidence of their effectiveness…”
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Guidance for the practical management of warfarin therapy in the treatment of venous thromboembolism by Witt, Daniel M., Clark, Nathan P., Kaatz, Scott, Schnurr, Terri, Ansell, Jack E.

“…Venous thromboembolism (VTE) is a serious and often fatal medical condition with an increasing incidence. The treatment of VTE is undergoing tremendous changes…”
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The perioperative management of antithrombotic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) by Douketis, James D, Berger, Peter B, Dunn, Andrew S, Jaffer, Amir K, Spyropoulos, Alex C, Becker, Richard C, Ansell, Jack

“…This article discusses the perioperative management of antithrombotic therapy and is part of the American College of Chest Physicians Evidence-Based Clinical…”
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Guidance for the practical management of the direct oral anticoagulants (DOACs) in VTE treatment by Burnett, Allison E., Mahan, Charles E., Vazquez, Sara R., Oertel, Lynn B., Garcia, David A., Ansell, Jack

“…Venous thromboembolism (VTE) is a serious medical condition associated with significant morbidity and mortality, and an incidence that is expected to double in…”
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Reversing the Effect of Oral Anticoagulant Drugs: Established and Newer Options by Ansell, Jack E.

“…The vitamin K antagonists (VKAs) have been the standard (and only) oral anticoagulants used for the long-term treatment or prevention of venous thromboembolism…”
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Guidance for the treatment of deep vein thrombosis and pulmonary embolism by Streiff, Michael B., Agnelli, Giancarlo, Connors, Jean M., Crowther, Mark, Eichinger, Sabine, Lopes, Renato, McBane, Robert D., Moll, Stephan, Ansell, Jack

“…This guidance document focuses on the diagnosis and treatment of venous thromboembolism (VTE). Efficient, cost effective diagnosis of VTE is facilitated by…”
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Ciraparantag safely and completely reverses the anticoagulant effects of low molecular weight heparin by Ansell, Jack E, Laulicht, Bryan E, Bakhru, Sasha H, Hoffman, Maureane, Steiner, Solomon S, Costin, James C

“…Abstract Major bleeding with low molecular weight heparin (LMWH) therapy occurs in up to 5% of patients and its anticoagulation is only partially reversed by…”
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American Society of Hematology 2018 guidelines for management of venous thromboembolism: optimal management of anticoagulation therapy by Witt, Daniel M., Nieuwlaat, Robby, Clark, Nathan P., Ansell, Jack, Holbrook, Anne, Skov, Jane, Shehab, Nadine, Mock, Juliet, Myers, Tarra, Dentali, Francesco, Crowther, Mark A., Agarwal, Arnav, Bhatt, Meha, Khatib, Rasha, Riva, John J., Zhang, Yuan, Guyatt, Gordon

“…Background: Clinicians confront numerous practical issues in optimizing the use of anticoagulants to treat venous thromboembolism (VTE). Objective: These…”
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Physician practices regarding contraindications to oral anticoagulation in atrial fibrillation: Findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry by O'Brien, Emily C., PhD, Holmes, DaJuanicia N., MS, Ansell, Jack E., MD, Allen, Larry A., MD, MHS, Hylek, Elaine, MD, Kowey, Peter R., MD, Gersh, Bernard J., MB, ChB, DPhil, Fonarow, Gregg C., MD, Koller, Christopher R., BA, Ezekowitz, Michael D., MB, ChB, DPhil, Mahaffey, Kenneth W., MD, Chang, Paul, MD, Peterson, Eric D., MD, MPH, Piccini, Jonathan P., MD, MHS, Singer, Daniel E., MD, MA

“…Background Oral anticoagulation (OAC) therapy reduces the risk of thromboembolic events associated with atrial fibrillation (AF), yet a substantial proportion…”
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Apixaban for Reduction In Stroke and Other ThromboemboLic Events in Atrial Fibrillation (ARISTOTLE) trial: Design and rationale by Lopes, Renato D., MD, PhD, Alexander, John H., MD, MHS, Al-Khatib, Sana M., MD, MHS, Ansell, Jack, MD, Diaz, Raphael, MD, Easton, J. Donald, MD, Gersh, Bernard J., MB, ChB, DPhil, Granger, Christopher B., MD, Hanna, Michael, MD, Horowitz, John, MD, Hylek, Elaine M., MD, MPH, McMurray, John J.V., MD, Verheugt, Freek W.A., MD, PhD, Wallentin, Lars, MD, PhD

“…Atrial fibrillation (AF) is associated with increased risk of stroke that can be attenuated with vitamin K antagonists (VKAs). Vitamin K antagonist use is…”
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Association of frailty and cognitive impairment with benefits of oral anticoagulation in patients with atrial fibrillation by Madhavan, Malini, Holmes, DaJuanicia N., Piccini, Jonathan P., Ansell, Jack E., Fonarow, Gregg C., Hylek, Elaine M., Kowey, Peter R., Mahaffey, Kenneth W., Thomas, Laine, Peterson, Eric D., Chan, Paul, Allen, Larry A., Gersh, Bernard J.

“…The incidence of cognitive impairment and frailty increase with age and may impact both therapy and outcomes in atrial fibrillation (AF). We examined the…”
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National Assessment of Warfarin Anticoagulation Therapy for Stroke Prevention in Atrial Fibrillation by Dlott, Jeffrey S, George, Roberta A, Huang, Xiaohua, Odeh, Mouneer, Kaufman, Harvey W, Ansell, Jack, Hylek, Elaine M

“…BACKGROUND—Anticoagulation control with warfarin, as assessed by the international normalized ratio (INR), is challenging. Time in the therapeutic range has…”
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