Search Results - "Ansari, Mubeen A"

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex by Ansari, Mubeen A, Scheff, Stephen W

“…We investigated oxidative stress in human postmortem frontal cortexfrom individuals characterized as mild cognitive impairment (n= 8), mild/moderate Alzheimer…”
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NADPH-oxidase activation and cognition in Alzheimer disease progression by Ansari, Mubeen A., Scheff, Stephen W.

“…Superoxide production via NADPH-oxidase (NOX) has been shown to play a role in a variety of neurological disorders, including Alzheimer disease (AD). To…”
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Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury by Ansari, Mubeen A., Roberts, Kelly N., Scheff, Stephen W.

“…Oxidative stress, an imbalance between oxidants and antioxidants, contributes to the pathogenesis of traumatic brain injury (TBI). Oxidative neurodegeneration…”
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Deciphering Early and Progressive Molecular Signatures in Alzheimer's Disease through Integrated Longitudinal Proteomic and Pathway Analysis in a Rodent Model by Yadikar, Hamad, Ansari, Mubeen A, Abu-Farha, Mohamed, Joseph, Shibu, Thomas, Betty T, Al-Mulla, Fahd

“…Alzheimer's disease (AD), the leading cause of dementia worldwide, remains a challenge due to its complex origin and degenerative character. The need for…”
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Insights into early pathogenesis of sporadic Alzheimer's disease: role of oxidative stress and loss of synaptic proteins by Ansari, Mubeen A, Rao, Muddanna Sakkattu, Al-Jarallah, Aishah

“…Oxidative stress, induced by impaired insulin signaling in the brain contributes to cognitive loss in sporadic Alzheimer's disease (sAD). This study evaluated…”
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A time course of NADPH-oxidase up-regulation and endothelial nitric oxide synthase activation in the hippocampus following neurotrauma by Ansari, Mubeen A., Roberts, Kelly N., Scheff, Stephen W.

“…Nicotinamide adenine dinucleotide phosphate oxidase (NADPH-oxidase; NOX) is a complex enzyme responsible for increased levels of reactive oxygen species (ROS),…”
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A time course of contusion-induced oxidative stress and synaptic proteins in cortex in a rat model of TBI by Ansari, Mubeen A, Roberts, Kelly N, Scheff, Stephen W

“…An imbalance between oxidants and antioxidants has been postulated to lead to oxidative damage in traumatic brain injury (TBI). Oxidative neurodegeneration is…”
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Impaired Insulin Signaling Alters Mediators of Hippocampal Synaptic Dynamics/Plasticity: A Possible Mechanism of Hyperglycemia-Induced Cognitive Impairment by Ansari, Mubeen A, Al-Jarallah, Aishah, Babiker, Fawzi A

“…Alzheimer's disease (AD) is a neurological condition that affects the elderly and is characterized by progressive and irreversible neurodegeneration in the…”
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Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia by Khan, Mushfiquddin, Elango, Chinnasamy, Ansari, Mubeen A, Singh, Inderjit, Singh, Avtar K

“…Ischemic stroke is a neurovascular disease treatable by thrombolytic therapy, but the therapy has to be initiated within 3 h of the incident. This therapeutic…”
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Age-related changes in mitochondrial respiration and oxidative damage in the cerebral cortex of the Fischer 344 rat by Gilmer, Lesley K., Ansari, Mubeen A., Roberts, Kelly N., Scheff, Stephen W.

“…This study probed possible age-related changes in mitochondrial bioenergetics in naïve Fischer 344 rats. Synaptic and extrasynaptic mitochondria were isolated…”
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Age-related mitochondrial changes after traumatic brain injury by Gilmer, Lesley K, Ansari, Mubeen A, Roberts, Kelly N, Scheff, Stephen W

“…Mitochondrial dysfunction is known to occur following traumatic brain injury (TBI) and has been well characterized. This study assessed possible age-related…”
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Temporal profile of M1 and M2 responses in the hippocampus following early 24 h of neurotrauma by Ansari, Mubeen A

“…Abstract Traumatic brain injury (TBI) elicits complex inflammatory assets (M1 and M2 responses) in the brain that include the expression of various…”
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Upregulation of NADPH-oxidase, inducible nitric oxide synthase and apoptosis in the hippocampus following impaired insulin signaling in the rats: Development of sporadic Alzheimer’s disease by Ansari, Mubeen A., Al-Jarallah, Aishah, Rao, Muddanna S., Babiker, Ahmed, Bensalamah, Khaled

“…[Display omitted] •Investigations in two models of STZ induced impaired insulin function in the brain.•There is upregulation of NOX, iNOS, O2−, NO and…”
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Inhibition of NF-κB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia by Jatana, Manu, Giri, Shailendra, Ansari, Mubeen A, Elango, Chinnasamy, Singh, Avtar K, Singh, Inderjit, Khan, Mushfiquddin

“…BACKGROUND: Stroke is one of the leading causes of death worldwide and a major cause of morbidity and mortality in the United States of America. Brain…”
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Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer's disease pathology by Scheff, Stephen W., Ansari, Mubeen A., Mufson, Elliott J.

“…Neuritic amyloid plaques and neurofibrillary tangles are hallmarks of Alzheimer's disease (AD) and are major components used for the clinical diagnosis of this…”
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Early time course of oxidative stress in hippocampal synaptosomes and cognitive loss following impaired insulin signaling in rats: Development of sporadic Alzheimer’s disease by Ansari, Mubeen A., Rao, Muddanna S., Al-Jarallah, Aishah, Babiker, Fawzi M.

“…[Display omitted] Oxidative stress, caused by impaired insulin signaling, plays a pivotal role in the pathogenesis of sporadic Alzheimer’s disease (sAD). We…”
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Natural Compounds as a Therapeutic Intervention following Traumatic Brain Injury: The Role of Phytochemicals by Scheff, Stephen W, Ansari, Mubeen A

“…There has been a tremendous focus on the discovery and development of neuroprotective agents that might have clinical relevance following traumatic brain…”
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Temporal profile of M1 and M2 responses in the hippocampus following early 24h of neurotrauma by Ansari, Mubeen A.

“…Traumatic brain injury (TBI) elicits complex inflammatory assets (M1 and M2 responses) in the brain that include the expression of various cytokines/chemokines…”
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Synaptic change in the posterior cingulate gyrus in the progression of Alzheimer's disease by Scheff, Stephen W, Price, Douglas A, Ansari, Mubeen A, Roberts, Kelly N, Schmitt, Frederick A, Ikonomovic, Milos D, Mufson, Elliott J

“…Mild cognitive impairment (MCI) is considered to be an early stage in the progression of Alzheimer's disease (AD) providing an opportunity to investigate brain…”
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Neuroprotective effect of Pycnogenol® following traumatic brain injury by Scheff, Stephen W., Ansari, Mubeen A., Roberts, Kelly N.

“…Traumatic brain injury (TBI) involves primary and secondary injury cascades that underlie delayed neuronal dysfunction and death. Oxidative stress is one of…”
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