Search Results - "Ansari, Khairul I"

Antisense Transcript Long Noncoding RNA (lncRNA) HOTAIR is Transcriptionally Induced by Estradiol by Bhan, Arunoday, Hussain, Imran, Ansari, Khairul I., Kasiri, Sahba, Bashyal, Aarti, Mandal, Subhrangsu S.

“…HOTAIR (HOX antisense intergenic RNA) is a long noncoding RNA (lncRNA) that is transcribed from the antisense strand of homeobox C gene locus in chromosome 12…”
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The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches by Mineo, Marco, Ricklefs, Franz, Rooj, Arun K., Lyons, Shawn M., Ivanov, Pavel, Ansari, Khairul I., Nakano, Ichiro, Chiocca, E. Antonio, Godlewski, Jakub, Bronisz, Agnieszka

“…Long non-coding RNAs (lncRNAs) have an undefined role in the pathobiology of glioblastoma multiforme (GBM). These tumors are genetically and phenotypically…”
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Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1 by BRONISZ, Agnieszka, YAN WANG, OSTROWSKI, Michael C, HOCHBERG, Fred, WEISSLEDER, Ralph, LAWLER, Sean E, CHIOCCA, E. Antonio, GODLEWSKI, Jakub, NOWICKI, Michal O, PERUZZI, Pierpaolo, ANSARI, Khairul I, OGAWA, Daisuke, BALAJ, Leonora, DE RIENZO, Gianluca, MINEO, Marco, NAKANO, Ichiro

“…Extracellular vesicles have emerged as important mediators of intercellular communication in cancer, including by conveying tumor-promoting microRNAs between…”
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Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing by Ansari, Khairul I, Mandal, Subhrangsu S

“…Mixed lineage leukemias (MLLs) are an evolutionarily conserved trithorax family of human genes that play critical roles in HOX gene regulation and embryonic…”
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Histone Methyltransferase EZH2 Is Transcriptionally Induced by Estradiol as Well as Estrogenic Endocrine Disruptors Bisphenol-A and Diethylstilbestrol by Bhan, Arunoday, Hussain, Imran, Ansari, Khairul I., Bobzean, Samara A.M., Perrotti, Linda I., Mandal, Subhrangsu S.

“…Enhancer of Zeste homolog 2 (EZH2), a methyltransferase specific to histone 3 lysine 27, is a critical player in gene silencing and is overexpressed in breast…”
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Cooperation of neurotrophin receptor TrkB and Her2 in breast cancer cells facilitates brain metastases by Choy, Cecilia, Ansari, Khairul I, Neman, Josh, Hsu, Sarah, Duenas, Matthew J, Li, Hubert, Vaidehi, Nagarajan, Jandial, Rahul

“…Patients with primary breast cancer that is positive for human epidermal growth factor receptor 2 (Her2+) have a high risk of developing metastases in the…”
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Endocrine disrupting chemical, bisphenol-A, induces breast cancer associated gene HOXB9 expression in vitro and in vivo by Deb, Paromita, Bhan, Arunoday, Hussain, Imran, Ansari, Khairul I., Bobzean, Samara A., Pandita, Tej K., Perrotti, Linda I., Mandal, Subhrangsu S.

“…HOXB9 is a homeobox-containing gene that plays a key role in mammary gland development and is associated with breast and other types of cancer. Here, we…”
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Glucose-Based Regulation of miR-451/AMPK Signaling Depends on the OCT1 Transcription Factor by Ansari, Khairul I., Ogawa, Daisuke, Rooj, Arun K., Lawler, Sean E., Krichevsky, Anna M., Johnson, Mark D., Chiocca, E. Antonio, Bronisz, Agnieszka, Godlewski, Jakub

“…In aggressive, rapidly growing solid tumors such as glioblastoma multiforme (GBM), cancer cells face frequent dynamic changes in their microenvironment,…”
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Homeodomain‐containing protein HOXB9 regulates expression of growth and angiogenic factors, facilitates tumor growth in vitro and is overexpressed in breast cancer tissue by Shrestha, Bishakha, Ansari, Khairul I., Bhan, Arunoday, Kasiri, Sahba, Hussain, Imran, Mandal, Subhrangsu S.

“…HOXB9 is a homeobox‐containing gene and is critical for the development of mammary gland and sternum. HOXB9 is also regulated by estrogen and is critical for…”
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HOXA5 Expression Is Elevated in Breast Cancer and Is Transcriptionally Regulated by Estradiol by Hussain, Imran, Deb, Paromita, Chini, Avisankar, Obaid, Monira, Bhan, Arunoday, Ansari, Khairul I, Mishra, Bibhu P, Bobzean, Samara A, Udden, S M Nashir, Alluri, Prasanna G, Das, Hriday K, Brothers, Robert Matthew, Perrotti, Linda I, Mandal, Subhrangsu S

“…HOXA5 is a homeobox-containing gene associated with the development of the lung, gastrointestinal tract, and vertebrae. Here, we investigate potential roles…”
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MLL histone methylases in gene expression, hormone signaling and cell cycle by Ansari, Khairul I, Mishra, Bibhu P, Mandal, Subhrangsu S

“…Histone methyl-transferases (HMTs) are key enzymes that post-translationally methylate nuclear histone proteins and play critical roles in gene expression,…”
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Inhibition of Jumonji Histone Demethylases Selectively Suppresses HER2 + Breast Leptomeningeal Carcinomatosis Growth via Inhibition of GMCSF Expression by Bhan, Arunoday, Ansari, Khairul I, Chen, Mike Y, Jandial, Rahul

“…HER2 breast leptomeningeal carcinomatosis (HER2 LC) occurs when tumor cells spread to cerebrospinal fluid-containing leptomeninges surrounding the brain and…”
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Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia by Bhan, Arunoday, Deb, Paromita, Shihabeddin, Nadine, Ansari, Khairul I., Brotto, Marco, Mandal, Subhrangsu S.

“…Hypoxia signaling plays a critical role in tumor growth, angiogenesis, metastasis cancer, and aging. Under hypoxia, hypoxia-inducible factors (HIFs) are…”
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Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo by Bhan, Arunoday, Hussain, Imran, Ansari, Khairul I., Bobzean, Samara A.M., Perrotti, Linda I., Mandal, Subhrangsu S.

“…•Long non-coding RNA HOTAIR is a key player in breast cancer.•HOTAIR is induced by endocrine disruptors BPA and DES in vitro and in vivo.•MLL-histone…”
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Light influences how the fungal toxin deoxynivalenol affects plant cell death and defense responses by Ansari, Khairul I, Doyle, Siamsa M, Kacprzyk, Joanna, Khan, Mojibur R, Walter, Stephanie, Brennan, Josephine M, Arunachalam, Chanemouga Soundharam, McCabe, Paul F, Doohan, Fiona M

“…The Fusarium mycotoxin deoxynivalenol (DON) can cause cell death in wheat (Triticum aestivum), but can also reduce the level of cell death caused by heat shock…”
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Autocrine GMCSF Signaling Contributes to Growth of HER2 + Breast Leptomeningeal Carcinomatosis by Ansari, Khairul I, Bhan, Arunoday, Saotome, Mika, Tyagi, Antariksh, De Kumar, Bony, Chen, Clara, Takaku, Motoki, Jandial, Rahul

“…Leptomeningeal carcinomatosis (LC) occurs when tumor cells spread to the cerebrospinal fluid-containing leptomeninges surrounding the brain and spinal cord. LC…”
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Astrocytic IGFBP2 and CHI3L1 in cerebrospinal fluid drive cortical metastasis of HER2+breast cancer by Ansari, Khairul I., Bhan, Arunoday, Liu, Xueli, Chen, Mike Y., Jandial, Rahul

“…The brain is often reported as the first site of recurrence among breast cancer patients overexpressing human epidermal growth factor receptor 2 (HER2)…”
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HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4 by Ansari, Khairul I, Hussain, Imran, Kasiri, Sahba, Mandal, Subhrangsu S

“…HOXC10 is a critical player in the development of spinal cord, formation of neurons, and associated with human leukemia. We found that HOXC10 is overexpressed…”
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HOXC6 Is Transcriptionally Regulated via Coordination of MLL Histone Methylase and Estrogen Receptor in an Estrogen Environment by Ansari, Khairul I., Hussain, Imran, Shrestha, Bishakha, Kasiri, Sahba, Mandal, Subhrangsu S.

“…Homeobox (HOX)-containing gene HOXC6 is a critical player in mammary gland development and milk production, and is overexpressed in breast and prostate…”
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Astrocyte-induced Reelin expression drives proliferation of Her2+ breast cancer metastases by Jandial, Rahul, Choy, Cecilia, Levy, Danielle M, Chen, Mike Y, Ansari, Khairul I

“…Breast cancer metastasis to the brain develops after a clinical latency of years to even decades, suggesting that colonization of the brain is the most…”
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