Search Results - "Ansah, Felix"
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Diagnostic performance of Typhidot RDT in diagnosis of typhoid fever and antibiotic resistance characterisation in a cross-sectional study in Southern Ghana
Published in BMC infectious diseases (07-11-2024)“…Typhoid fever remains a significant public health problem contributing to significant misapplication of antibiotics in Ghana. However, there is little data on…”
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Phenotypic characterization of Ghanaian P. falciparum clinical isolates reveals a homogenous parasite population
Published in Frontiers in immunology (23-09-2022)“…Erythrocyte invasion by P. falciparum involves functionally overlapping interactions between the parasite's ligands and the erythrocyte surface receptors…”
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Towards the development of cost-effective point-of-care diagnostic tools for poverty-related infectious diseases in sub-Saharan Africa
Published in PeerJ (San Francisco, CA) (21-06-2024)“…In this review, we examine the current landscape of point-of-care testing (POCT) diagnostic tools designed for poverty-related infectious diseases (PRIDs) in…”
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4
Asymptomatic malaria and hepatitis B do not influence cytokine responses of persons involved in chronic sedentary activities
Published in BMC infectious diseases (14-12-2020)“…Chronic Sedentary lifestyles have been linked to increased odds of stress, elevated anxiety and diminished wellbeing, inducing cytokine production and…”
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Short-term cryopreservation and thawing have minimal effects on Plasmodium falciparum ex vivo invasion profile
Published in Frontiers in cellular and infection microbiology (20-09-2022)“…phenotyping of erythrocyte invasion diversity is important in the identification and down selection of potential malaria vaccine targets. However, due to the…”
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6
Amplification of GTP-cyclohydrolase 1 gene in Plasmodium falciparum isolates with the quadruple mutant of dihydrofolate reductase and dihydropteroate synthase genes in Ghana
Published in PloS one (28-09-2018)“…Sulfadoxine-pyrimethamine (SP) is used as malaria chemoprophylaxis for pregnant women and children in Ghana. Plasmodium falciparum resistance to SP is linked…”
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The temporal dynamics of Plasmodium species infection after artemisinin-based combination therapy (ACT) among asymptomatic children in the Hohoe municipality, Ghana
Published in Malaria journal (14-09-2023)“…The routine surveillance of asymptomatic malaria using nucleic acid-based amplification tests is essential in obtaining reliable data that would inform malaria…”
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Sensitive Detection of Asymptomatic and Symptomatic Malaria with Seven Novel Parasite-Specific LAMP Assays and Translation for Use at Point-of-Care
Published in Microbiology spectrum (15-06-2023)“…Human malaria is a life-threatening parasitic disease with high impact in the sub-Saharan Africa region, where 95% of global cases occurred in 2021. While most…”
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Analysis of Plasmodium falciparum Rh2b deletion polymorphism across different transmission areas
Published in Scientific reports (30-01-2020)“…Despite significant progress in controlling malaria, the disease remains a global health burden. The intricate interactions the parasite Plasmodium falciparum…”
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Comparative Susceptibility of Plasmodium ovale and Plasmodium falciparum Field Isolates to Reference and Lead Candidate Antimalarial Drugs in Ghana
Published in Microbiology spectrum (15-06-2023)“…Malaria treatments resulted in the decline of the deadliest Plasmodium falciparum globally while species, such as , infections have been increasingly detected…”
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MMV006087 is a potent Malaria Box compound against Plasmodium falciparum clinical parasites
Published in Frontiers in drug discovery (15-06-2023)“…The emergence of drug-resistant malaria parasites to artemisinin and its partner drugs highlights the need to increase the arsenal of new antimalarials with…”
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12
Plasmodium falciparum Merozoite Associated Armadillo Protein (PfMAAP) Is Apically Localized in Free Merozoites and Antibodies Are Associated With Reduced Risk of Malaria
Published in Frontiers in immunology (07-04-2020)“…Understanding the functional role of proteins expressed by is an important step toward unlocking potential targets for the development of therapeutic or…”
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13
Antimalarial activity of Malaria Box Compounds against Plasmodium falciparum clinical isolates
Published in International journal for parasitology -- drugs and drug resistance (01-12-2017)“…Malaria remains a major cause of childhood deaths in resource-limited settings. In the absence of an effective vaccine, drugs and other interventions have…”
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14
Chemical Heating for Minimally Instrumented Point-of-Care (POC) Molecular Diagnostics
Published in Biosensors (Basel) (13-11-2024)“…The minimal instrumentation of portable medical diagnostic devices for point-of-care applications is facilitated by using chemical heating in place of…”
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Analysis and validation of silica-immobilised BST polymerase in loop-mediated isothermal amplification (LAMP) for malaria diagnosis
Published in Analytical and bioanalytical chemistry (01-09-2022)“…Bacillus stearothermophilus large fragment (BST LF ) DNA polymerase is reported, isolated on silica via a fused R5 silica-affinity peptide and used in nucleic…”
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Ultrasensitive electrochemical genosensors for species-specific diagnosis of malaria
Published in Electrochimica acta (10-10-2022)“…•Electrochemical genosensors were developed for species-specific diagnosis of malaria.•The genosensors are the first biosensors for detecting P. malariae and…”
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Cellular immune response to SARS-CoV-2 and clinical presentation in individuals exposed to endemic malaria
Published in Cell reports (Cambridge) (27-08-2024)“…Ghana and other parts of West Africa have experienced lower COVID-19 mortality rates than other regions. This phenomenon has been hypothesized to be associated…”
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Development of Cooperative Primer-Based Real-Time PCR Assays for the Detection of Plasmodium malariae and Plasmodium ovale
Published in The Journal of molecular diagnostics : JMD (01-10-2021)“…Plasmodium malariae and Plasmodium ovale are increasingly gaining public health attention as the global transmission of falciparum malaria is decreasing…”
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Prevalence of chloroquine and antifolate drug resistance alleles in Plasmodium falciparum clinical isolates from three areas in Ghana
Published in AAS open research (01-01-2018)“…Background: The emergence and spread of resistance in Plasmodium falciparum to chloroquine (CQ) necessitated the change from CQ to artemisinin-based…”
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20
High-throughput genotyping assays for identification of glycophorin B deletion variants in population studies
Published in Experimental biology and medicine (Maywood, N.J.) (01-04-2021)“…Glycophorins are the most abundant sialoglycoproteins on the surface of human erythrocyte membranes. Genetic variation in glycophorin region of human…”
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