Search Results - "Anosova, Natalie"

Beta variant COVID-19 protein booster vaccine elicits durable cross-neutralization against SARS-CoV-2 variants in non-human primates by Pavot, Vincent, Berry, Catherine, Kishko, Michael, Anosova, Natalie G., Li, Lu, Tibbitts, Tim, Huang, Dean, Raillard, Alice, Gautheron, Sylviane, Gutzeit, Cindy, Koutsoukos, Marguerite, Chicz, Roman M., Lecouturier, Valerie

“…The rapid spread of the SARS-CoV-2 Omicron subvariants, despite the implementation of booster vaccination, has raised questions about the durability of…”
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Protein-based SARS-CoV-2 spike vaccine booster increases cross-neutralization against SARS-CoV-2 variants of concern in non-human primates by Pavot, Vincent, Berry, Catherine, Kishko, Michael, Anosova, Natalie G., Huang, Dean, Tibbitts, Tim, Raillard, Alice, Gautheron, Sylviane, Gutzeit, Cindy, Koutsoukos, Marguerite, Chicz, Roman M., Lecouturier, Valerie

“…The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that partly evade neutralizing antibodies raises concerns of reduced…”
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Development of multivalent mRNA vaccine candidates for seasonal or pandemic influenza by Chivukula, Sudha, Plitnik, Timothy, Tibbitts, Timothy, Karve, Shrirang, Dias, Anusha, Zhang, Donghui, Goldman, Rebecca, Gopani, Hardip, Khanmohammed, Asad, Sarode, Ashish, Cooper, Dustin, Yoon, Heesik, Kim, Younghoon, Yan, Yanhua, Mundle, Sophia T., Groppo, Rachel, Beauvais, Adrien, Zhang, Jinrong, Anosova, Natalie G., Lai, Charles, Li, Lu, Ulinski, Gregory, Piepenhagen, Peter, DiNapoli, Joshua, Kalnin, Kirill V., Landolfi, Victoria, Swearingen, Ron, Fu, Tong-Ming, DeRosa, Frank, Casimiro, Danilo

“…Recent approval of mRNA vaccines for emergency use against COVID-19 is likely to promote rapid development of mRNA-based vaccines targeting a wide range of…”
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Pan-SARS neutralizing responses after third boost vaccination in non-human primate immunogenicity model by Kalnin, Kirill V., Plitnik, Timothy, Kishko, Michael, Huang, Dean, Raillard, Alice, Piolat, Julie, Anosova, Natalie G., Tibbitts, Timothy, DiNapoli, Joshua, Karve, Shrirang, Goldman, Rebecca, Gopani, Hardip, Dias, Anusha, Tran, Khang, Zacharia, Minnie, Gu, Xiaobo, Boeglin, Lianne, Abysalh, Jonathan, Vargas, Jorel, Beaulieu, Angela, Shah, Monic, Jeannotte, Travis, Gillis, Kimberly, Chivukula, Sudha, Swearingen, Ron, Landolfi, Victoria, Fu, Tong-Ming, DeRosa, Frank, Casimiro, Danilo

“…•No breadth against VoC attained with heterologous sequences in primary vaccination.•Boosting with original vaccine results in breadth against VoC and…”
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Deciphering the domain specificity of C. difficile toxin neutralizing antibodies by Cole, Leah E., Li, Lu, Jetley, Utsav, Zhang, Jinrong, Pacheco, Kristl, Ma, Fuqin, Zhang, Jianxin, Mundle, Sophia, Yan, Yanhua, Barone, Lucianna, Rogers, Christopher, Beltraminelli, Nicola, Quemeneur, Laurence, Kleanthous, Harry, Anderson, Stephen F., Anosova, Natalie G.

“…Clostridium difficile infection (CDI) is the principal cause of nosocomial diarrhea and pseudomembranous colitis associated with antibiotic therapy. The…”
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Immunogenicity and efficacy of mRNA COVID-19 vaccine MRT5500 in preclinical animal models by Kalnin, Kirill V., Plitnik, Timothy, Kishko, Michael, Zhang, Jinrong, Zhang, Donghui, Beauvais, Adrien, Anosova, Natalie G., Tibbitts, Tim, DiNapoli, Josh, Ulinski, Gregory, Piepenhagen, Peter, Cummings, Sheila M., Bangari, Dinesh S., Ryan, Susan, Huang, Po-Wei D., Huleatt, James, Vincent, Deanne, Fries, Katherine, Karve, Shrirang, Goldman, Rebecca, Gopani, Hardip, Dias, Anusha, Tran, Khang, Zacharia, Minnie, Gu, Xiaobo, Boeglin, Lianne, Abysalh, Jonathan, Vargas, Jorel, Beaulieu, Angela, Shah, Monic, Jeannotte, Travis, Gillis, Kimberly, Chivukula, Sudha, Swearingen, Ron, Landolfi, Victoria, Fu, Tong-Ming, DeRosa, Frank, Casimiro, Danilo

“…Emergency use authorization of COVID vaccines has brought hope to mitigate pandemic of coronavirus disease 2019 (COVID-19). However, there remains a need for…”
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Proteomic profiling of precipitated Clostridioides difficile toxin A and B antibodies by Adamson, Penelope J., Wang, Jing J., Anosova, Natalie G., Colella, Alex D., Chataway, Timothy K., Kleanthous, Harry, Gordon, Tom P., Gordon, David L.

“…•Anti-toxin A and B Igs purified from sera after C. difficile infection or vaccination.•Proteomes of secreted anti-toxin Igs analysed by mass spectrometric…”
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Limitations of Murine Models for Assessment of Antibody-Mediated Therapies or Vaccine Candidates against Staphylococcus epidermidis Bloodstream Infection by Cole, Leah E, Zhang, Jinrong, Kesselly, Augustus, Anosova, Natalie G, Lam, Hubert, Kleanthous, Harry, Yethon, Jeremy A

“…Staphylococcus epidermidis is normally a commensal colonizer of human skin and mucus membranes, but, due to its ability to form biofilms on indwelling medical…”
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Systemic antibody responses induced by a two-component Clostridium difficile toxoid vaccine protect against C. difficile-associated disease in hamsters by Anosova, Natalie G, Brown, Anna M, Li, Lu, Liu, Nana, Cole, Leah E, Zhang, Jinrong, Mehta, Hersh, Kleanthous, Harry

“…Clostridium difficile infection (CDI) has been identified as the leading cause of nosocomial diarrhoea and pseudomembranous colitis associated with antibiotic…”
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A Combination of Three Fully Human Toxin A- and Toxin B-Specific Monoclonal Antibodies Protects against Challenge with Highly Virulent Epidemic Strains of Clostridium difficile in the Hamster Model by Anosova, Natalie G, Cole, Leah E, Li, Lu, Zhang, Jinrong, Brown, Anna M, Mundle, Sophia, Zhang, Jianxin, Ray, Satyajit, Ma, Fuqin, Garrone, Pierre, Bertraminelli, Nicola, Kleanthous, Harry, Anderson, Stephen F

“…Clostridium difficile infection (CDI) is the principal cause of nosocomial diarrhea and pseudomembranous colitis associated with antibiotic therapy. Recent…”
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Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization in macaques and protection in hamsters by Berry, Catherine, Pavot, Vincent, Anosova, Natalie G., Kishko, Michael, Li, Lu, Tibbitts, Tim, Raillard, Alice, Gautheron, Sylviane, Cummings, Sheila, Bangari, Dinesh S., Kar, Swagata, Atyeo, Caroline, Deng, Yixiang, Alter, Galit, Gutzeit, Cindy, Koutsoukos, Marguerite, Chicz, Roman M., Lecouturier, Valerie

“…Background Since the beginning of the COVID-19 pandemic, several variants of concern (VOC) have emerged for which there is evidence of an increase in…”
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Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting by Cole, Leah E, Zhang, Jinrong, Pacheco, Kristl M, Lhéritier, Philippe, Anosova, Natalie G, Piolat, Julie, Zheng, Lingyi, Reveneau, Nathalie

“…While both whole-cell (wP) and acellular pertussis (aP) vaccines have been highly effective at reducing the global pertussis disease burden, there are concerns…”
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Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B by Liu, Jinyu, Kothe, Michael, Zhang, Jianxin, Oloo, Eliud, Stegalkina, Svetlana, Mundle, Sophia T., Li, Lu, Zhang, Jinrong, Cole, Leah E., Barone, Lucianna, Biemann, Hans-Peter, Kleanthous, Harry, Anosova, Natalie G., Anderson, Stephen F.

“…Clostridium difficile toxins are the primary causative agents for hospital-acquired diarrhea and pseudomembranous colitis. Numerous monoclonal antibodies…”
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Tolerance to Noninherited Maternal MHC Antigens in Mice by Andrassy, Joachim, Kusaka, Satoshi, Jankowska-Gan, Ewa, Torrealba, Jose R, Haynes, Lynn D, Marthaler, Brodie R, Tam, Robert C, Illigens, Ben M.-W, Anosova, Natalie, Benichou, Gilles, Burlingham, William J

“…The phenomenon of tolerance to noninherited maternal Ags (NIMA) is poorly understood. To analyze the NIMA effect C57BL/6 (H-2(b/b)) males were mated with…”
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CD28-independent Costimulation of T Cells in Alloimmune Responses by Yamada, Akira, Kishimoto, Koji, Dong, Victor M, Sho, Masayuki, Salama, Alan D, Anosova, Natalie G, Benichou, Gilles, Mandelbrot, Didier A, Sharpe, Arlene H, Turka, Laurence A, Auchincloss, Hugh, Jr, Sayegh, Mohamed H

“…T cell costimulation by B7 molecules plays an important role in the regulation of alloimmune responses. Although both B7-1 and B7-2 bind CD28 and CTLA-4 on T…”
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The relative contribution of direct and indirect antigen recognition pathways to the alloresponse and graft rejection depends upon the nature of the transplant by Illigens, Ben M, Yamada, Akira, Fedoseyeva, Eugenia V, Anosova, Natalie, Boisgerault, Florence, Valujskikh, Anna, Heeger, Peter S, Sayegh, Mohamed H, Boehm, Bernhard, Benichou, Gilles

“…In this study, we measured direct and indirect T-cell alloresponses mediated by CD4 + and CD8 + T cells in three mouse transplantation models: skin, cornea,…”
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CD4+ T Cell Responses to Self- and Mutated p53 Determinants During Tumorigenesis in Mice by Fedoseyeva, Eugenia V, Boisgerault, Florence, Anosova, Natalie G, Wollish, Wendy S, Arlotta, Paola, Jensen, Peter E, Ono, Santa J, Benichou, Gilles

“…We analyzed CD4+ T helper responses to wild-type (wt) and mutated (mut) p53 protein in normal and tumor-bearing mice. In normal mice, we observed that although…”
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Induction of T-cell response to cryptic MHC determinants during allograft rejection by Boisgérault, Florence, Anosova, Natalie G, Tam, Robert C, Illigens, Ben M.-W, Fedoseyeva, Eugenia V, Benichou, Gilles

“…The presentation of MHC peptides by recipient and donor antigen presenting cells is an essential element in allorecognition and allograft rejection. MHC…”
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Development of a RANKL ELISPOT assay as a tool for periodontal disease research (TECH2P.913) by Zhang, Jinrong, Cole, Leah, Brown, Anna, Ma, Bing, Anosova, Natalie, McCluskey, Jacqueline

“…Periodontal disease (PD) results from the immune response to the bacterial components of the sub-gingival plaque. PD progresses from gingival inflammation, to…”
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Increasing Domain Coverage Improves Neutralizing Potency of C. difficile Toxin-specific Antibodies by Li, Lu, Cole, Leah E., Jetley, Utsav, Zhang, Jinrong, Pacheco, Kristl, Ma, Fuqin, Zhang, Jianxin, Mundle, Sophia, Yan, Yanhua, Barone, Lucianna, Rogers, Christopher, Beltraminelli, Nicola, Quemeneur, Laurence, Kleanthous, Harry, Anderson, Stephen F., Anosova, Natalie G.

“…Clostridiumdifficile (C.difficile)is a significant human pathogen. C.difficile infection (CDI) causesclinical symptoms ranging from diarrhea to…”
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