Search Results - "Annual review of pharmacology and toxicology"

Big Data and Artificial Intelligence Modeling for Drug Discovery by Zhu, Hao

“…Due to the massive data sets available for drug candidates, modern drug discovery has advanced to the big data era. Central to this shift is the development of…”
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Modulating NRF2 in Disease: Timing Is Everything by Dodson, Matthew, de la Vega, Montserrat Rojo, Cholanians, Aram B, Schmidlin, Cody J, Chapman, Eli, Zhang, Donna D

“…The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central regulator of redox, metabolic, and protein homeostasis that…”
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Nanoparticle Toxicology by Yang, Wen, Wang, Lin, Mettenbrink, Evan M, DeAngelis, Paul L, Wilhelm, Stefan

“…Nanoparticles from natural and anthropogenic sources are abundant in the environment, thus human exposure to nanoparticles is inevitable. Due to this constant…”
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Microbiota-Gut-Brain Axis: New Therapeutic Opportunities by Long-Smith, Caitríona, O'Riordan, Kenneth J, Clarke, Gerard, Stanton, Catherine, Dinan, Timothy G, Cryan, John F

“…The traditional fields of pharmacology and toxicology are beginning to consider the substantial impact our gut microbiota has on host physiology. The…”
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Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span by Robbins, Paul D, Jurk, Diana, Khosla, Sundeep, Kirkland, James L, LeBrasseur, Nathan K, Miller, Jordan D, Passos, João F, Pignolo, Robert J, Tchkonia, Tamar, Niedernhofer, Laura J

“…Senescence is the consequence of a signaling mechanism activated in stressed cells to prevent proliferation of cells with damage. Senescent cells (Sncs) often…”
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Aptamers as Therapeutics by Nimjee, Shahid M, White, Rebekah R, Becker, Richard C, Sullenger, Bruce A

“…Aptamers are single-stranded nucleic acid molecules that bind to and inhibit proteins and are commonly produced by systematic evolution of ligands by…”
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Environmental Obesogens: Mechanisms and Controversies by Heindel, Jerrold J, Blumberg, Bruce

“…Obesity is a worldwide pandemic in adults as well as children and adds greatly to health care costs through its association with type 2 diabetes, metabolic…”
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Arsenic: A Global Environmental Challenge by Chen, Qiao Yi, Costa, Max

“…Arsenic is a naturally occurring metalloid and one of the few metals that can be metabolized inside the human body. The pervasive presence of arsenic in nature…”
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Structure and Pharmacology of Voltage-Gated Sodium and Calcium Channels by Catterall, William A, Lenaeus, Michael J, Gamal El-Din, Tamer M

“…Voltage-gated sodium and calcium channels are evolutionarily related transmembrane signaling proteins that initiate action potentials, neurotransmission,…”
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Proteasome Inhibitor Drugs by Fricker, Lloyd D

“…Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into peptides. There are many distinct forms of proteasomes that differ…”
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Neonicotinoid Insecticides: Molecular Targets, Resistance, and Toxicity by Matsuda, Kazuhiko, Ihara, Makoto, Sattelle, David B

“…Neonicotinoids have been used to protect crops and animals from insect pests since the 1990s, but there are concerns regarding their adverse effects on…”
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MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective by Liu, Jiabei, Clough, Shannon J, Hutchinson, Anthony J, Adamah-Biassi, Ekue B, Popovska-Gorevski, Marina, Dubocovich, Margarita L

“…Melatonin, or 5-methoxy- N -acetyltryptamine, is synthesized and released by the pineal gland and locally in the retina following a circadian rhythm, with low…”
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Role of Nrf2 in Oxidative Stress and Toxicity by Ma, Qiang

“…Organismal life encounters reactive oxidants from internal metabolism and environmental toxicant exposure. Reactive oxygen and nitrogen species cause oxidative…”
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Therapeutic Oligonucleotides: State of the Art by Smith, C.I. Edvard, Zain, Rula

“…Oligonucleotides (ONs) can interfere with biomolecules representing the entire extended central dogma. Antisense gapmer, steric block, splice-switching ONs,…”
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Pharmacology of Antisense Drugs by Bennett, C. Frank, Baker, Brenda F, Pham, Nguyen, Swayze, Eric, Geary, Richard S

“…Recent studies have led to a greater appreciation of the diverse roles RNAs play in maintaining normal cellular function and how they contribute to disease…”
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Metals and Mechanisms of Carcinogenesis by Chen, Qiao Yi, DesMarais, Thomas, Costa, Max

“…Metal exposure is pervasive and not limited to sporadic poisoning events or toxic waste sites. Hundreds of millions of people around the globe are affected by…”
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Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies by Lesnefsky, Edward J, Chen, Qun, Tandler, Bernard, Hoppel, Charles L

“…Mitochondria have emerged as key participants in and regulators of myocardial injury during ischemia and reperfusion. This review examines the sites of damage…”
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Pharmacologic Targeting of Hypoxia-Inducible Factors by Semenza, Gregg L

“…Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O 2 availability. HIFs are heterodimeric proteins composed of an O 2 -regulated…”
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Neuropathic Pain: Mechanism-Based Therapeutics by Bannister, Kirsty, Sachau, Juliane, Baron, Ralf, Dickenson, Anthony H

“…Neuropathic pain (NeP) can result from sources as varied as nerve compression, channelopathies, autoimmune disease, and incision. By identifying the…”
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The Opioid Epidemic: Crisis and Solutions by Skolnick, Phil

“…The widespread abuse of prescription opioids and a dramatic increase in the availability of illicit opioids have created what is commonly referred to as the…”
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