Search Results - "Annual review of medicine"

The Gut-Brain Axis by Mayer, Emeran A, Nance, Karina, Chen, Shelley

“…Preclinical evidence has firmly established bidirectional interactions among the brain, the gut, and the gut microbiome. Candidate signaling molecules and at…”
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Phage Therapy for Antibiotic-Resistant Bacterial Infections by Hatfull, Graham F, Dedrick, Rebekah M, Schooley, Robert T

“…Antibiotic resistance in bacterial pathogens presents a substantial threat to the control of infectious diseases. Development of new classes of antibiotics has…”
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CD40 Agonist Antibodies in Cancer Immunotherapy by Vonderheide, Robert H

“…CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T…”
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Treatment of Advanced Prostate Cancer by Teo, Min Yuen, Rathkopf, Dana E, Kantoff, Philip

“…The therapeutic landscape of prostate cancer has been transformed over the last decade by new therapeutics, advanced functional imaging, next-generation…”
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Therapeutic Antisense Oligonucleotides Are Coming of Age by Bennett, C. Frank

“…The first published description of therapeutic applications of antisense oligonucleotide (ASO) technology occurred in the late 1970s and was followed by the…”
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CAR T Cell Therapy for Solid Tumors by Newick, Kheng, O'Brien, Shaun, Moon, Edmund, Albelda, Steven M

“…The field of cancer immunotherapy has been re-energized by the application of chimeric antigen receptor (CAR) T cell therapy in cancers. These CAR T cells are…”
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CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions by Hashimoto, Masao, Kamphorst, Alice O, Im, Se Jin, Kissick, Haydn T, Pillai, Rathi N, Ramalingam, Suresh S, Araki, Koichi, Ahmed, Rafi

“…Antigen-specific CD8 T cells are central to the control of chronic infections and cancer, but persistent antigen stimulation results in T cell exhaustion…”
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Entering the Modern Era of Gene Therapy by Anguela, Xavier M, High, Katherine A

“…Gene therapies are gaining momentum as promising early successes in clinical studies accumulate and examples of regulatory approval for licensing increase…”
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Hepcidin and Iron in Health and Disease by Nemeth, Elizabeta, Ganz, Tomas

“…Hepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total body iron content. Hepcidin, secreted by hepatocytes, functions by…”
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The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention by O'Shea, John J, Schwartz, Daniella M, Villarino, Alejandro V, Gadina, Massimo, McInnes, Iain B, Laurence, Arian

“…The Janus kinase (JAK)-signal transducer of activators of transcription (STAT) pathway is now recognized as an evolutionarily conserved signaling pathway…”
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Targeting RAGE Signaling in Inflammatory Disease by Hudson, Barry I, Lippman, Marc E

“…The receptor for advanced glycation end-products (RAGE) is a multiligand pattern recognition receptor implicated in diverse chronic inflammatory states. RAGE…”
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The PI3K AKT Pathway as a Target for Cancer Treatment by Mayer, Ingrid A, Arteaga, Carlos L

“…Anticancer targeted therapies are designed to exploit a particular vulnerability in the tumor, which in most cases results from its dependence on an oncogene…”
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mRNA Vaccines in the COVID-19 Pandemic and Beyond by Hogan, Michael J, Pardi, Norbert

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly…”
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Liver Cancer: Connections with Obesity, Fatty Liver, and Cirrhosis by Marengo, Andrea, Rosso, Chiara, Bugianesi, Elisabetta

“…The burden of hepatocellular carcinoma (HCC), the most common form of liver cancer, is steadily growing because obesity, type 2 diabetes, and nonalcoholic…”
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Acute Kidney Injury by Zuk, Anna, Bonventre, Joseph V

“…Acute kidney injury (AKI) is a global public health concern associated with high morbidity, mortality, and healthcare costs. Other than dialysis, no…”
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Update on Alzheimer's Disease Therapy and Prevention Strategies by Graham, W. Vallen, Bonito-Oliva, Alessandra, Sakmar, Thomas P

“…Alzheimer's disease (AD) is the primary cause of age-related dementia. Effective strategies to prevent and treat AD remain elusive despite major efforts to…”
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Clinical Application and Potential of Fecal Microbiota Transplantation by Ooijevaar, R.E, Terveer, E.M, Verspaget, H.W, Kuijper, E.J, Keller, J.J

“…Fecal microbiota transplantation (FMT) is a well-established treatment for recurrent Clostridioides difficile infection. FMT has become a more readily…”
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Zika, Chikungunya, and Other Emerging Vector-Borne Viral Diseases by Weaver, Scott C, Charlier, Caroline, Vasilakis, Nikos, Lecuit, Marc

“…Arthropod-borne viruses (arboviruses) have a long history of emerging to infect humans, but during recent decades, they have been spreading more widely and…”
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Hepatocellular Carcinoma Immunotherapy by Sperandio, Rubens Copia, Pestana, Roberto Carmagnani, Miyamura, Beatriz Viesser, Kaseb, Ahmed O

“…Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and the third leading cause of cancer-related death worldwide. Single-agent…”
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The Gut Microbiome and Inflammatory Bowel Diseases by Shan, Yue, Lee, Mirae, Chang, Eugene B

“…Inflammatory bowel diseases (IBD) arise from a convergence of genetic risk, environmental factors, and gut microbiota, where each is necessary but not…”
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