Search Results - "Annette W. K. Tso"

Lipocalin-2 Is an Inflammatory Marker Closely Associated with Obesity, Insulin Resistance, and Hyperglycemia in Humans by Wang, Yu, Lam, Karen S. L, Kraegen, Edward W, Sweeney, Gary, Zhang, Jialiang, Tso, Annette W.K, Chow, Wing-Sun, Wat, Nelson M.S, Xu, Jian Yu, Hoo, Ruby L.C, Xu, Aimin

“…Lipocalin-2, a 25-kDa secreted glycoprotein, is a useful biomarker for early detection of various renal injuries. Because lipocalin-2 is abundantly expressed…”
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Validation of the diabetes screening tools proposed by the American Diabetes Association in an aging Chinese population by Woo, Yu Cho, Lee, Chi Ho, Fong, Carol H Y, Tso, Annette W K, Cheung, Bernard M Y, Lam, Karen S L

“…Diabetes is a serious global health problem. A simple and effective screening tool should have substantial public health benefit. We investigated the…”
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Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese by Ong, Kwok Leung, Li, Mingfang, Tso, Annette W K, Xu, Aimin, Cherny, Stacey S, Sham, Pak Chung, Tse, Hung Fat, Lam, Tai Hing, Cheung, Bernard M Y, Lam, Karen S L

“…ObjectiveLow plasma adiponectin level can predict the development of hypertension after 5 years in our population. We therefore investigated whether…”
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Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population by Cheung, Chloe Y. Y, Tso, Annette W. K, Cheung, Bernard M. Y, Xu, Aimin, Ong, K. L, Fong, Carol H. Y, Wat, Nelson M. S, Janus, Edward D, Sham, Pak C, Lam, Karen S. L

“…Context: Recent large-scale genome-wide association studies identified novel genetic variants associated with obesity and body mass index (BMI) in addition to…”
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Angiopoietin-Like Protein 4 Decreases Blood Glucose and Improves Glucose Tolerance but Induces Hyperlipidemia and Hepatic Steatosis in Mice by Xu, Aimin, Lam, Michael C., Chan, Kok Weng, Wang, Yu, Zhang, Jialiang, Ruby L. C. Hoo, Xu, Jian Yu, Chen, Baoying, Chow, Wing-Sun, Annette W. K. Tso, Karen S. L. Lam, Unger, Roger H.

“…Angiopoietin-like protein 4 (ANGPTL4) is a circulating protein predominantly expressed in adipose tissue and liver. Several recent studies demonstrated that…”
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Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction by Woo, Yu-Cho, Tso, Annette W K, Xu, Aimin, Law, Lawrence S C, Fong, Carol H Y, Lam, Tai-Hing, Lo, Su-Vui, Wat, Nelson M S, Cheung, Bernard M Y, Lam, Karen S L

“…Adipose tissue inflammation and dysregulated adipokine secretion are implicated in obesity-related insulin resistance and type 2 diabetes. We evaluated the use…”
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Plasma Level of Pigment Epithelium-Derived Factor Is Independently Associated with the Development of the Metabolic Syndrome in Chinese Men: A 10-Year Prospective Study by Chen, Cheng, Tso, Annette W. K, Law, Lawrence S. C, Cheung, Bernard M. Y, Ong, K. L, Wat, Nelson M. S, Janus, Edward D, Xu, Aimin, Lam, Karen S. L

“…Objective: Pigment epithelium-derived factor (PEDF), a serine protease inhibitor, is secreted from the adipose tissue and circulates at high concentrations. A…”
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Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans by XINMEI ZHANG, YEUNG, Dennis C. Y, AIMIN XU, KARPISEK, Michal, STEJSKAL, David, ZHOU, Zhi-Guang, FENG LIU, WONG, Rachel L. C, CHOW, Wing-Sun, TSO, Annette W. K, LAM, Karen S. L

“…Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans Xinmei Zhang 1 2 , Dennis C.Y. Yeung 1 2 ,…”
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Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene by Cheung, Bernard M Y, Ong, Kwok Leung, Tso, Annette W K, Leung, Raymond Y H, Cherny, Stacey S, Sham, Pak Chung, Lam, Tai Hing, Lam, Karen S L

“…ObjectiveAdrenomedullin (ADM) plays an important role in inflammation and is a marker of future cardiovascular events. We studied common single nucleotide…”
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Diabetes Prevalence and Therapeutic Target Achievement in the United States, 1999 to 2006 by Cheung, Bernard M.Y., PhD, FRCP, Lond, FRCP Edin, FCP, Ong, Kwok Leung, MPhil, Cherny, Stacey S., PhD, Sham, Pak-Chung, MRPsych, PhD, Tso, Annette W.K., MRCP(UK), Lam, Karen S.L., MD, FRCP, FRACP

“…Abstract Objective Changes in the prevalence, treatment, and management of diabetes in the United States from 1999 to 2006 were studied using data from the…”
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High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects by Chen, Cheng, Cheung, Bernard M.Y, Tso, Annette W.K, Wang, Yudong, Law, Lawrence S.C, Ong, Kwok Leung, Wat, Nelson M.S, Xu, Aimin, Lam, Karen S.L

“…OBJECTIVE: To investigate whether circulating levels of fibroblast growth factor 21 (FGF21), which previously has been shown to be elevated in obesity, could…”
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Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study by Cheung, Chloe Y Y, Tso, Annette W K, Cheung, Bernard M Y, Xu, Aimin, Ong, K L, Law, Lawrence S C, Wat, Nelson M S, Janus, Edward D, Sham, Pak C, Lam, Karen S L

“…ObjectiveCentral obesity predisposes to various cardiometabolic diseases and is a key component of the metabolic syndrome (MetS). We have previously…”
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Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese by Ong, Kwok Leung, Jiang, Chao Qiang, Liu, Bin, Jin, Ya Li, Tso, Annette W.K., Tam, Sidney, Wong, Ka Sing, Tomlinson, Brian, Cheung, Bernard M.Y., Lin, Jie Ming, Yue, Xiao Jun, Lam, Karen S.L., Lam, Tai Hing, Thomas, Graham Neil

“…Summary Objective  Single nucleotide polymorphisms (SNPs) in the apolipoprotein A5 gene (APOA5) are associated with hypertriglyceridaemia in our population. We…”
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Serum Adipocyte Fatty Acid-Binding Protein as a New Biomarker Predicting the Development of Type 2 Diabetes: A 10-year prospective study in a Chinese cohort by Tso, Annette W.K, Xu, Aimin, Sham, Pak C, Wat, Nelson M.S, Wang, Yu, Fong, Carol H.Y, Cheung, Bernard M.Y, Janus, Edward D, Lam, Karen S.L

“…OBJECTIVE:-- Adipocyte fatty acid-binding protein (A-FABP) is abundantly expressed in adipocytes and plays a role in glucose homeostasis in experimental…”
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The KCNJ11 E23K polymorphism and progression of glycaemia in Southern Chinese: a long-term prospective study by Cheung, Chloe Y Y, Tso, Annette W K, Cheung, Bernard M Y, Xu, Aimin, Fong, Carol H Y, Ong, K L, Law, Lawrence S C, Wat, Nelson M S, Janus, Edward D, Sham, Pak C, Lam, Karen S L

“…The KCNJ11 E23K variant is associated with type 2 diabetes mellitus (T2DM) in cross-sectional studies, but conflicting findings have been reported from…”
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Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome : A 5-year prospective study by AIMIN XU, TSO, Annette W. K, CHEUNG, Bernard M. Y, YU WANG, WAT, Nelson M. S, FONG, Carol H. Y, YEUNG, Dennis C. Y, JANUS, Edward D, SHAM, Pak C, LAM, Karen S. L

“…Adipocyte-fatty acid binding protein (A-FABP), a major cytoplasmic protein in adipocytes, plays a central role in the development of diabetes and…”
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Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study by Xu, Jian Yu, Sham, Pak C., Xu, Aimin, Tso, Annette W. K., Wat, Nelson M. S., Cheng, King Yip, Fong, Carol H. Y., Janus, Edward D., Lam, Karen S. L.

“…Summary Objective  Human resistin gene (RETN) polymorphisms have been found to be associated with type 2 diabetes (T2DM), insulin resistance and/or obesity. We…”
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STAT3 signalling is required for leptin regulation of energy balance but not reproduction by Myers, Martin G, Bates, Sarah H, Stearns, Walter H, Dundon, Trevor A, Schubert, Markus, Tso, Annette W. K, Wang, Yongping, Banks, Alexander S, Lavery, Hugh J, Haq, Asma K, Maratos-Flier, Eleftheria, Neel, Benjamin G, Schwartz, Michael W

“…Secretion of leptin from adipocytes communicates body energy status to the brain by activating the leptin receptor long form (LRb). LRb regulates energy…”
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Serum fibroblast growth factor 21 is a superior biomarker to other adipokines in predicting incident diabetes by Woo, Yu Cho, Lee, Chi Ho, Fong, Carol H.Y., Xu, Aimin, Tso, Annette W.K., Cheung, Bernard M.Y., Lam, Karen S.L.

“…Summary Objective Fibroblast growth factor 21 (FGF21) improves glucose and lipid metabolism, but high circulating levels are found in type 2 diabetes,…”
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Relationship of Plasma Interleukin-6 and Its Genetic Variants With Hypertension in Hong Kong Chinese by Cheung, Bernard M.Y., Ong, Kwok Leung, Tso, Annette W.K., Leung, Raymond Y.H., Cherny, Stacey S., Sham, Pak Chung, Thomas, G. Neil, Lam, Tai Hing, Lam, Karen S.L.

“…Background Interleukin-6 (IL6) plays a central role in inflammation, insulin resistance, and atherogenesis. We investigated the associations of plasma IL6 and…”
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