Search Results - "Annett, Geralyn"
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Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-derived Neurotrophic Factor Improve Outcomes in Huntington's Disease Mouse Models
Published in Molecular therapy (01-05-2016)“…Huntington's disease (HD) is a fatal degenerative autosomal dominant neuropsychiatric disease that causes neuronal death and is characterized by progressive…”
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Allele-Specific Reduction of the Mutant Huntingtin Allele Using Transcription Activator-Like Effectors in Human Huntington's Disease Fibroblasts
Published in Cell transplantation (01-04-2016)“…Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an abnormal expansion of CAG repeats. Although pathogenesis has been…”
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Genetically Engineered Mesenchymal Stem Cells as a Proposed Therapeutic for Huntington’s Disease
Published in Molecular neurobiology (01-02-2012)“…There is much interest in the use of mesenchymal stem cells/marrow stromal cells (MSC) to treat neurodegenerative disorders, in particular those that are fatal…”
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Preclinical evaluation of mesenchymal stem cells overexpressing VEGF to treat critical limb ischemia
Published in Molecular therapy. Methods & clinical development (01-01-2016)“…Numerous clinical trials are utilizing mesenchymal stem cells (MSC) to treat critical limb ischemia, primarily for their ability to secrete signals that…”
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Clinical trial perspective for adult and juvenile Huntington's disease using genetically-engineered mesenchymal stem cells
Published in Neural regeneration research (01-05-2016)“…Progress to date from our group and others indicate that using genetically-engineered mesenchymal stem cells (MSC) to secrete brain-derived neurotrophic factor…”
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Clinical trial perspective for adult and juvenile Huntington's disease using genetically-engineered mesenchymal stem cells
Published in Neural regeneration research (01-01-2016)“…Progress to date from our group and others indicate that using genetically-engineered mesenchymal stem cells(MSC) to secrete brain-derived neurotrophic…”
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MDR1 gene expression in brain of patients with medically intractable epilepsy
Published in Epilepsia (Copenhagen) (01-01-1995)“…Why some patients with seizures are successfully treated with antiepileptic drugs (AEDs) and others prove medically intractable is not known. Inadequate…”
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Mesenchymal stem cells for the treatment of neurodegenerative disease
Published in Regenerative medicine (01-11-2010)“…Mesenchymal stem cells/marrow stromal cells (MSCs) present a promising tool for cell therapy, and are currently being tested in US FDA-approved clinical trials…”
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Engineered BDNF producing cells as a potential treatment for neurologic disease
Published in Expert opinion on biological therapy (02-08-2016)“…Brain-derived neurotrophic factor (BDNF) has been implicated in wide range of neurological diseases and injury. This neurotrophic factor is vital for neuronal…”
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Intravitreal Administration of Human Bone Marrow CD34+ Stem Cells in a Murine Model of Retinal Degeneration
Published in Investigative ophthalmology & visual science (01-08-2016)“…Intravitreal murine lineage-negative bone marrow (BM) hematopoietic cells slow down retinal degeneration. Because human BM CD34+ hematopoietic cells are not…”
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Mesenchymal stem/stromal cells genetically engineered to produce vascular endothelial growth factor for revascularization in wound healing and ischemic conditions
Published in Transfusion (Philadelphia, Pa.) (01-02-2019)“…Mesenchymal stem/stromal cells (MSCs) may be able to improve ischemic conditions as they can actively seek out areas of low oxygen and secrete proangiogenic…”
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Mesenchymal stem cells for the sustained in vivo delivery of bioactive factors
Published in Advanced drug delivery reviews (30-09-2010)“…Mesenchymal stem cells (MSC) are a promising tool for cell therapy, either through direct contribution to the repair of bone, tendon and cartilage or as an…”
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Contribution of human hematopoietic stem cells to liver repair
Published in Seminars in immunopathology (01-09-2009)“…Immune-deficient mouse models of liver damage allow examination of human stem cell migration to sites of damage and subsequent contribution to repair and…”
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Mesenchymal stem cells for trinucleotide repeat disorders
Published in Methods in molecular biology (Clifton, N.J.) (2013)“…Mesenchymal stem cells/marrow stromal cells (MSCs) are ideally suited for cellular therapy due to their ease of isolation, manipulation, and strong safety…”
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Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-derived Neurotrophic Factor Improve Outcomes in Huntington's Disease Mouse Models super(MT) Open
Published in Molecular therapy (01-05-2016)“…Huntington's disease (HD) is a fatal degenerative autosomal dominant neuropsychiatric disease that causes neuronal death and is characterized by progressive…”
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California Umbilical Cord Blood Collection Program: Addressing The Diversity Of The National Registry Through Creative Partnerships With Cord Blood Banks and Provision Of High-Quality Cord Blood Units For Research
Published in Blood (15-11-2013)“…California's Umbilical Cord Blood Collection Program (UCBCP) is a unique, state-funded system designed to capture the diverse HLA profiles of its residents'…”
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PRE-CELL: Clinical and Novel Biomarker Measures of Disease Progression in a Lead-In-Observational Study for a Planned Phase 1 Trial of Genetically-Modified Mesenchymal Stem Cells Over-Expressing BDNF in Patients with Huntington’s Disease (S25.004)
Published in Neurology (05-04-2016)“…Abstract only…”
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Mesenchymal Stem Cells Engineered to Overexpress Brain-Derived Neurotrophic Factor as a Proposed Therapeutic for Huntington’s Disease (S25.007)
Published in Neurology (05-04-2016)“…Abstract only…”
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A Novel State Funded Program to Increase Cord Blood Collections for Public Banking
Published in Biology of blood and marrow transplantation (01-02-2013)Get full text
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Clinical Laboratory/Good Manufacturing Practice Facility Hybrid Offers Flexibility and Cost-Effective Product Quality Control
Published in American journal of clinical pathology (01-07-2012)Get full text
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