Search Results - "Annet B. Zuidhof"

Arginase Inhibition Protects against Allergen-induced Airway Obstruction, Hyperresponsiveness, and Inflammation by Maarsingh, Harm, Zuidhof, Annet B, Bos, I. Sophie T, van Duin, Marcel, Boucher, Jean-Luc, Zaagsma, Johan, Meurs, Herman

“…In a guinea pig model of allergic asthma, using perfused tracheal preparations ex vivo, we demonstrated that L-arginine limitation due to increased arginase…”
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The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammation by Schaafsma, Dedmer, Bos, I Sophie T, Zuidhof, Annet B, Zaagsma, Johan, Meurs, Herman

“…Recently, we have shown that allergen-induced airway hyperresponsiveness (AHR) after the early (EAR) and late (LAR) asthmatic reaction in guinea pigs could be…”
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Effects of (a Combination of) the Beta2-Adrenoceptor Agonist Indacaterol and the Muscarinic Receptor Antagonist Glycopyrrolate on Intrapulmonary Airway Constriction by Maarsingh, Harm, Oldenburger, Anouk, Han, Bing, Zuidhof, Annet B., Elzinga, Carolina R. S., Timens, Wim, Meurs, Herman, Sopi, Ramadan B., Schmidt, Martina

“…Expression of bronchodilatory β2-adrenoceptors and bronchoconstrictive muscarinic M3-receptors alter with airway size. In COPD, (a combination of) β2-agonists…”
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Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction by Schaafsma, Dedmer, Bos, I Sophie T, Zuidhof, Annet B, Zaagsma, Johan, Meurs, Herman

“…In guinea pigs, we have previously demonstrated that the contribution of Rho-kinase to airway responsiveness in vivo and ex vivo is enhanced after active…”
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Small airway hyperresponsiveness in COPD: relationship between structure and function in lung slices by Maarsingh, Harm, Bidan, Cécile M, Brook, Bindi S, Zuidhof, Annet B, Elzinga, Carolina R S, Smit, Marieke, Oldenburger, Anouk, Gosens, Reinoud, Timens, Wim, Meurs, Herman

“…The direct relationship between pulmonary structural changes and airway hyperresponsiveness (AHR) in chronic obstructive pulmonary disease (COPD) is unclear…”
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Bronchoprotection by olodaterol is synergistically enhanced by tiotropium in a guinea pig model of allergic asthma by Smit, Marieke, Zuidhof, Annet B, Bos, Sophie I T, Maarsingh, Harm, Gosens, Reinoud, Zaagsma, Johan, Meurs, Herman

“…The novel once-daily β₂-agonist bronchodilator drug olodaterol has recently been shown to be effective in patients with allergic asthma for >24 hours. An…”
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Dual action of iNOS-derived nitric oxide in allergen-induced airway hyperreactivity in conscious, unrestrained guinea pigs by SCHUILING, M, MEURS, H, ZUIDHOF, A. B, VENEMA, N, ZAAGSMA, J

“…Using a guinea pig model of acute allergic asthma, we recently established that a deficiency of nitric oxide (NO) contributes to airway hyperreactivity (AHR)…”
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The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease by Han, Bing, Poppinga, Wilfred J., Zuo, Haoxiao, Zuidhof, Annet B., Bos, I. Sophie T., Smit, Marieke, Vogelaar, Pieter, Krenning, Guido, Henning, Robert H., Maarsingh, Harm, Halayko, Andrew J., van Vliet, Bernard, Stienstra, Stef, Graaf, Adrianus Cornelis van der, Meurs, Herman, Schmidt, Martina

“…COPD is characterized by persistent airflow limitation, neutrophilia and oxidative stress from endogenous and exogenous insults. Current COPD therapy involving…”
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Role of tachykinin NK2‐receptor activation in the allergen‐induced late asthmatic reaction, airway hyperreactivity and airway inflammatory cell influx in conscious, unrestrained guinea‐pigs by Schuiling, Martin, Zuidhof, Annet B, Meurs, Herman, Zaagsma, Johan

“…In a guinea‐pig model of allergic asthma, we investigated the involvement of the tachykinin NK2 receptors in allergen‐induced early (EAR) and late (LAR)…”
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A guinea pig model of acute and chronic asthma using permanently instrumented and unrestrained animals by Meurs, Herman, Santing, Ruud E, Remie, René, van der Mark, Thomas W, Westerhof, Fiona J, Zuidhof, Annet B, Bos, I Sophie T, Zaagsma, Johan

“…To investigate mechanisms underlying allergen-induced asthmatic reactions, airway hyperresponsiveness and remodeling, we have developed a guinea pig model of…”
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Inhibition of Rho-kinase normalizes nonspecific hyperresponsiveness in passively sensitized airway smooth muscle preparations by Schaafsma, Dedmer, Zuidhof, Annet B., Nelemans, S.A., Zaagsma, Johan, Meurs, Herman

“…Currently, little is known about mechanisms underlying passive sensitization-induced nonspecific airway hyperresponsiveness. We sought to determine whether the…”
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Role of nitric oxide in the development and partial reversal of allergen‐induced airway hyperreactivity in conscious, unrestrained guinea‐pigs by Schuiling, Martin, Zuidhof, Annet B., Bonouvrie, Monique A. A., Venema, Nicolette, Zaagsma, Johan, Meurs, Herman

“…Using a conscious, unrestrained guinea‐pig model of allergic asthma, we investigated the role of endogenous nitric oxide (NO) in the regulation of airway…”
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Inflammatory cell distribution in guinea pig airways and its relationship to airway reactivity by Westerhof, F, Timens, W, van Oosten, A, Zuidhof, A B, Nauta, N, Schuiling, M, Vos, J T, Zaagsma, J, Meurs, H, Coers, W

“…Although airway inflammation and airway hyperreactivity are observed after allergen inhalation both in allergic humans and animals, little is known about the…”
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Role of tachykinin NK 2 ‐receptor activation in the allergen‐induced late asthmatic reaction, airway hyperreactivity and airway inflammatory cell influx in conscious, unrestrained guinea‐pigs by Schuiling, Martin, Zuidhof, Annet B, Meurs, Herman, Zaagsma, Johan

“…In a guinea‐pig model of allergic asthma, we investigated the involvement of the tachykinin NK 2 receptors in allergen‐induced early (EAR) and late (LAR)…”
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Involvement of tachykinin NK1 receptor in the development of allergen-induced airway hyperreactivity and airway inflammation in conscious, unrestrained guinea pigs by SCHUILING, M, ZUIDHOF, A. B, ZAAGSMA, J, MEURS, H

“…It has been suggested that tachykinin NK1 receptor-mediated neurogenic inflammation, characterized by microvascular leakage, mucus secretion, and infiltration…”
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Involvement of Tachykinin NK 1 Receptor in the Development of Allergen-induced Airway Hyperreactivity and Airway Inflammation in Conscious, Unrestrained Guinea Pigs by SCHUILING, MARTIN, ZUIDHOF, ANNET B., ZAAGSMA, JOHAN, MEURS, HERMAN

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Inflammatory cell distribution in guinea pig airways and its relationship to airway reactivity by Fiona Westerhof, Wim Timens, Annemiek van Oosten, Annet B. Zuidhof, Nathalie Nauta, Martin Schuiling, Johannes T. W. M. Vos, Johan Zaagsma, Herman Meurs, Wilko Coers

“…ALTHOUGH airway inflammation and airway hyperreactivity are observed after allergen inhalation both in allergic humans and animals, little is known about the…”
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