Search Results - "Annels, N. E."

Combination of a fusogenic glycoprotein, pro-drug activation and oncolytic HSV as an intravesical therapy for superficial bladder cancer by Simpson, G R, Horvath, A, Annels, N E, Pencavel, T, Metcalf, S, Seth, R, Peschard, P, Price, T, Coffin, R S, Mostafid, H, Melcher, A A, Harrington, K J, Pandha, H S

“…Background: There are still no effective treatments for superficial bladder cancer (SBC)/non-muscle invasive bladder cancer. Following treatment, 20% of…”
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Immediate early and early lytic cycle proteins are frequent targets of the Epstein-Barr virus-induced cytotoxic T cell response by Steven, N M, Annels, N E, Kumar, A, Leese, A M, Kurilla, M G, Rickinson, A B

“…Epstein-Barr virus (EBV), a human gamma-herpesvirus, can establish both nonproductive (latent) and productive (lytic) infections. Although the CD8+ cytotoxic T…”
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Differences in telomerase expression by the CD1a⁺ cells in Langerhans cell histiocytosis reflect the diverse clinical presentation of the disease by da Costa, CET, Egeler, RM, Hoogeboom, M, Szuhai, K, Forsyth, RG, Niesters, M, de Krijger, RR, Tazi, A, Hogendoorn, PCW, Annels, NE

“…Langerhans cell histiocytosis (LCH) is a disease characterized by an uncontrolled clonal proliferation of Langerhans cells, whose aetiology is still unclear…”
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Changing Patterns of Dominant TCR Usage with Maturation of an EBV-Specific Cytotoxic T Cell Response by Annels, Nicola E, Callan, Margaret F. C, Tan, Linda, Rickinson, Alan B

“…Infection with EBV provides a unique opportunity to follow the human CD8(+) T cell response to a persistent, genetically stable agent from the primary phase,…”
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T–cell memory: lessons from Epstein–Barr virus infection in man by Rickinson, A. B., Callan, M. F. C., Annels, N. E.

“…Epstein–Barr virus offers an ideal opportunity to follow the human T–cell response to a virus infection over time from its acute primary phase, as seen in…”
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Spontaneous antibodies against Engrailed‐2 (EN2) protein in patients with prostate cancer by Annels, N. E., Simpson, G. R., Denyer, M., McGrath, S. E., Falgari, G., Killick, E., Eeles, R., Stebbing, J., Pchejetski, D., Cutress, R., Murray, N., Michael, A., Pandha, H.

“…Summary We reported the expression of the homeodomain‐containing transcription factor Engrailed‐2 (EN2) in prostate cancer and showed that the presence of EN2…”
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Use of gemcitabine- (Gem) and fluropyrimidine (FP)-based chemotherapy to reduce myeloid-derived suppressor cells (MDSCs) in pancreatic (PC) and esophagogastric cancer (EGC) by Gabitass, R. F., Annels, N. E., Crawshaw, J., Pandha, H. S., Middleton, G. W.

“…Abstract only…”
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A Re-Evaluation of the Frequency of CD8+ T Cells Specific for EBV in Healthy Virus Carriers by Tan, Linda C, Gudgeon, Nancy, Annels, Nicola E, Hansasuta, Pokrath, O'Callaghan, Chris A, Rowland-Jones, Sarah, McMichael, Andrew J, Rickinson, Alan B, Callan, Margaret F. C

“…EBV is a gammaherpesvirus that can establish both nonproductive (latent) and productive (lytic) infections within the cells of its host. Although T cell…”
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Langerhans-cell histiocytosis ‘insight into DC biology’ by Laman, Jon D., Leenen, Pieter J.M., Annels, Nicola E., Hogendoorn, Pancras C.W., Maarten Egeler, R.

“…Langerhans-cell histiocytosis (LCH) is caused by an uncontrolled pathogenic clonal proliferation of dendritic cells (DCs) with Langerhans-cell (LC)…”
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Memory T Cells Constitute a Subset of the Human CD8+CD45RA+ Pool with Distinct Phenotypic and Migratory Characteristics by Faint, Jeffery M, Annels, Nicola E, Curnow, S. John, Shields, Philip, Pilling, Darrell, Hislop, Andrew D, Wu, Lijun, Akbar, Arne N, Buckley, Christopher D, Moss, Paul A. H, Adams, David H, Rickinson, Alan B, Salmon, Mike

“…Using HLA class I-viral epitope tetramers to monitor herpes virus-specific CD8(+) T cell responses in humans, we have shown that a significant fraction of…”
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Epitope focusing in the primary cytotoxic T cell response to Epstein-Barr virus and its relationship to T cell memory by Steven, N M, Leese, A M, Annels, N E, Lee, S P, Rickinson, A B

“…The relationship between primary and memory cytotoxic T lymphocyte (CTL) responses, and the factors influencing entry into memory, are poorly understood. Here…”
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Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL by Annels, Nicola E., Willemze, Annemieke J., van der Velden, Vincent H.J., Faaij, Claudia M.J.M., van Wering, Elisabeth, Sie-Go, Daisy M.D.S., Egeler, R. Maarten, van Tol, Maarten J.D., Révész, Tom

“…Childhood acute lymphoblastic leukemia (ALL) is often associated with extramedullary infiltration by leukemic cells at diagnosis or at relapse. To understand…”
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EN2: A candidate antigen for the development of targeted therapies in ovarian cancer by Michael, A., Riley, C., Bokaee, S., Denyer, M., Pandha, H. S., Annels, N. E.

“…Abstract only…”
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Prevalence and prognostic significance of myeloid-derived suppressor cells and regulatory T cells in pancreatic and esophagogastric cancer by Gabitass, R. F., Annels, N. E., Pandha, H. S., Middleton, G. W.

“…Abstract only…”
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Management of Epstein-Barr Virus (EBV) Reactivation after Allogeneic Stem Cell Transplantation by Simultaneous Analysis of EBV DNA Load and EBV-Specific T Cell Reconstitution by Annels, Nicola E., Kalpoe, Jayant S., Bredius, Robbert G. M., Claas, Eric C., Kroes, Aloys C. M., Hislop, Andrew D., van Baarle, Debbie, Egeler, R. Maarten, van Tol, Maarten J. D., Lankester, Arjan C.

“…Background. Epstein-Barr virus (EBV) reactivation is a frequent event after allogeneic stem cell transplantation and may progress to life-threatening…”
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Epitope-specific evolution of human CD8(+) T cell responses from primary to persistent phases of Epstein-Barr virus infection by Hislop, Andrew D, Annels, Nicola E, Gudgeon, Nancy H, Leese, Alison M, Rickinson, Alan B

“…Primary virus infection often elicits a large CD8(+) T cell response which subsequently contracts to a smaller memory T cell pool; the relationship between…”
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Aberrant chemokine receptor expression and chemokine production by Langerhans cells underlies the pathogenesis of Langerhans cell histiocytosis by Annels, Nicola E, Da Costa, Cristiana E T, Prins, Frans A, Willemze, Annemieke, Hogendoorn, Pancras C W, Egeler, R Maarten

“…Langerhans cell histiocytosis (LCH) is characterized by a clonal proliferation and retention of cells with a Langerhans cell (LC)-like phenotype at various…”
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Presence of osteoclast-like multinucleated giant cells in the bone and nonostotic lesions of Langerhans cell histiocytosis by da Costa, Cristiana E T, Annels, Nicola E, Faaij, Claudia M J M, Forsyth, Ramses G, Hogendoorn, Pancras C W, Egeler, R Maarten

“…Langerhans cell histiocytosis (LCH) is a disease that can involve one or multiple organ systems characterized by an accumulation of CD1a(+) Langerhans-like…”
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Epstein-Barr virus–specific CD8+ T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential by Dunne, Padraic J., Faint, Jeffery M., Gudgeon, Nancy H., Fletcher, Jean M., Plunkett, Fiona J., Soares, Maria Vieira D., Hislop, Andrew D., Annels, Nicola E., Rickinson, Alan B., Salmon, Mike, Akbar, Arne N.

“…During acute infection, latent and lytic Epstein-Barr virus (EBV) epitope-specific CD8+ T cells have a CD45RO+CD45RA− phenotype. However, after resolution of…”
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Epitope-specific Evolution of Human CD8 super(+) T Cell Responses from Primary to Persistent Phases of Epstein-Barr Virus Infection by Hislop, AD, Annels, N E, Gudgeon, N H, Leese, A M, Rickinson, AB

“…Primary virus infection often elicits a large CD8 super(+) T cell response which subsequently contracts to a smaller memory T cell pool; the relationship…”
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