Search Results - "Annedi, Subhash C."

Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase Open New Prospects for the Treatment of Neurological Disorders by Annedi, Subhash C

“…The disubstituted pyrimidines based SAR study by Silverman et al. ( J. Med. Chem. 2014, DOI: 10.1021/jm501719e) was focused on improving bioavailability and…”
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Discovery of cis-N-(1-(4-(Methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: A 1,6-Disubstituted Indoline Derivative as a Highly Selective Inhibitor of Human Neuronal Nitric Oxide Synthase (nNOS) without Any Cardiovascular Liabilities by Annedi, Subhash C, Ramnauth, Jailall, Maddaford, Shawn P, Renton, Paul, Rakhit, Suman, Mladenova, Gabriela, Dove, Peter, Silverman, Sarah, Andrews, John S, Felice, Milena D, Porreca, Frank

“…A series of 1,6-disubstituted indoline derivatives were synthesized and evaluated as inhibitors of human nitric oxide synthase (NOS) designed to mitigate the…”
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1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors by Renton, Paul, Speed, Joanne, Maddaford, Shawn, Annedi, Subhash C., Ramnauth, Jailall, Rakhit, Suman, Andrews, John

“…A series of 1,5-disubstituted indole derivatives was designed, synthesized and evaluated as inhibitors of human nitric oxide synthase. A variety of flexible…”
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First-in-Class, Dual-Action, 3,5-Disubstituted Indole Derivatives Having Human Nitric Oxide Synthase (nNOS) and Norepinephrine Reuptake Inhibitory (NERI) Activity for the Treatment of Neuropathic Pain by Mladenova, Gabriela, Annedi, Subhash C, Ramnauth, Jailall, Maddaford, Shawn P, Rakhit, Suman, Andrews, John S, Zhang, Dongqin, Porreca, Frank

“…A family of different 3,5-disubstituted indole derivatives having 6-membered rings were designed, synthesized, and demonstrated inhibition of human nitric…”
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Design, Synthesis, and Biological Evaluation of 3,4-Dihydroquinolin-2(1H)-one and 1,2,3,4-Tetrahydroquinoline-Based Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors by Ramnauth, Jailall, Speed, Joanne, Maddaford, Shawn P, Dove, Peter, Annedi, Subhash C, Renton, Paul, Rakhit, Suman, Andrews, John, Silverman, Sarah, Mladenova, Gabriela, Zinghini, Salvatore, Nair, Sheela, Catalano, Concettina, Lee, David K.H, De Felice, Milena, Porreca, Frank

“…Neuronal nitric oxide synthase (nNOS) inhibitors are effective in preclinical models of many neurological disorders. In this study, two related series of…”
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Discovery of N-(3-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a Selective Inhibitor of Human Neuronal Nitric Oxide Synthase (nNOS) for the Treatment of Pain by Annedi, Subhash C, Maddaford, Shawn P, Mladenova, Gabriela, Ramnauth, Jailall, Rakhit, Suman, Andrews, John S, Lee, David K. H, Zhang, Dongqin, Porreca, Frank, Bunton, David, Christie, Lee

“…3,6-Disubstituted indole derivatives were designed, synthesized, and evaluated as inhibitors of human nitric oxide synthase (NOS). Bulky amine containing…”
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Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine by Annedi, Subhash C., Maddaford, Shawn P., Ramnauth, Jailall, Renton, Paul, Rybak, Taras, Silverman, Sarah, Rakhit, Suman, Mladenova, Gabriela, Dove, Peter, Andrews, John S., Zhang, Dongqin, Porreca, Frank

“…We recently reported a series of 1,6-disubstituted indoline-based thiophene amidine compounds (5) as selective neuronal nitric oxide synthase (nNOS) inhibitors…”
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1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors by Maddaford, Shawn, Renton, Paul, Speed, Joanne, Annedi, Subhash C., Ramnauth, Jailall, Rakhit, Suman, Andrews, John, Mladenova, Gabriela, Majuta, Lisa, Porreca, Frank

“…A series of 1,6-disubstituted indole derivatives was designed, synthesized and evaluated as inhibitors of human nitric oxide synthase (NOS). By varying the…”
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Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS) by Annedi, Subhash C., Ramnauth, Jailall, Cossette, Michele, Maddaford, Shawn P., Dove, Peter, Rakhit, Suman, Andrews, John S., Porreca, Frank

“…R=various cyclic and acyclic basic amine side chains. Selective inhibitors of human neuronal nitric oxide synthase (nNOS). A novel class of 1,7-disubstituted…”
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3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors by Annedi, Subhash C., Maddaford, Shawn P., Ramnauth, Jailall, Renton, Paul, Speed, Joanne, Rakhit, Suman, Andrews, John S., Porreca, Frank

“…A series of 3,5-disubstituted indole derivatives was designed, synthesized and evaluated as inhibitors of human nitric oxide synthase (NOS). Various guanidine…”
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1,2,3,4-Tetrahydroquinoline-Based Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors: Lead Optimization Studies Resulting in the Identification of N-(1-(2-(Methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a Preclinical Development Candidate by Ramnauth, Jailall, Renton, Paul, Dove, Peter, Annedi, Subhash C, Speed, Joanne, Silverman, Sarah, Mladenova, Gabriela, Maddaford, Shawn P, Zinghini, Salvatore, Rakhit, Suman, Andrews, John, Lee, David K. H, Zhang, Dongqin, Porreca, Frank

“…Numerous studies have shown that selective nNOS inhibitors could be therapeutic in many neurological disorders. Previously, we reported a series of…”
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Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors by Patman, Joanne, Bhardwaj, Namrta, Ramnauth, Jailall, Annedi, Subhash C., Renton, Paul, Maddaford, Shawn P., Rakhit, Suman, Andrews, John S.

“…A novel series of 2-aminobenzothiazoles were synthesized and shown to be selective inhibitors of neuronal nitric oxide synthase (nNOS). A series of substituted…”
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An Unprecedented Twist to ODCase Catalytic Activity by Fujihashi, Masahiro, Bello, Angelica M, Poduch, Ewa, Wei, Lianhu, Annedi, Subhash C, Pai, Emil F, Kotra, Lakshmi P

“…Orotidine-5‘-monophosphate decarboxylase (ODCase) has evolved to catalyze a decarboxylation reaction, most probably via a carbanion species at the C6 position…”
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Design and Synthesis of Novel Fluoropeptidomimetics as Potential Mimics of the Transition State during Peptide Hydrolysis by Annedi, Subhash C, Li, Weiyong, Samson, Sheeba, Kotra, Lakshmi P

“…α-Fluoroamino acids were targeted in our ongoing efforts to design novel fluoropeptidomimetics (1) as potential protease inhibitors. α-Fluoroglycine derivative…”
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Engineering D-amino acid containing novel protease inhibitors using catalytic site architecture by ANNEDI, Subhash C, BIABANI, Farooq, PODUCH, Ewa, MANNARGUDI, Baskar M, MAJUMDER, Kanchana, LIANHU WEI, KHAYAT, Reza, LIANG TONG, KOTRA, Lakshmi P

“…The mechanism of proteolysis by serine proteases is a reasonably well-understood process. Typically, a histidine residue acting as a general base deprotonates…”
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Novel fluoropeptidomimetics: synthesis, stability studies and protease inhibition by Annedi, Subhash C., Majumder, Kanchana, Wei, Lianhu, Oyiliagu, Catherine E., Samson, Sheeba, Kotra, Lakshmi P.

“…[Display omitted] Designer fluoropeptidomimetics as protease inhibitors are revealed. The key peptidomimetic region in the inhibitors contains a ‘–CHF–S–’…”
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Design and Synthesis of Novel Fluoropeptidomimetics as Potential Mimics of the Transition State during Peptide Hydrolysis by Annedi, Subhash C, Li, Weiyong, Samson, Sheeba, Kotra, Lakshmi P

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Discovery of N -(3-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1 H -indol-6-yl) thiophene-2-carboximidamide as a Selective Inhibitor of Human Neuronal Nitric Oxide Synthase (nNOS) for the Treatment of Pain by Annedi, Subhash C., Maddaford, Shawn P., Mladenova, Gabriela, Ramnauth, Jailall, Rakhit, Suman, Andrews, John S., Lee, David K. H., Zhang, Dongqin, Porreca, Frank, Bunton, David, Christie, Lee

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Erratum to “Novel fluoropeptidomimetics: Synthesis, stability studies and protease inhibition” [Bioorg. Med. Chem. 13 (2005) 2943–2958] by Annedi, Subhash C., Majumder, Kanchana, Wei, Lianhu, Oyiliagu, Catherine E., Samson, Sheeba, Kotra, Lakshmi P.

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Chapter 2 Advancements in the Development of Nitric Oxide Synthase Inhibitors by Maddaford, Shawn, Annedi, Subhash C., Ramnauth, Jailall, Rakhit, Suman

“…This chapter focuses on recent advances in the design of the selective inhibitors of nitric oxide synthase (NOS) and some of the emerging preclinical and…”
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