Search Results - "Anne Conti, Mary"

NMII Forms a Contractile Transcellular Sarcomeric Network to Regulate Apical Cell Junctions and Tissue Geometry by Ebrahim, Seham, Fujita, Tomoki, Millis, Bryan A., Kozin, Elliott, Ma, Xuefei, Kawamoto, Sachiyo, Baird, Michelle A., Davidson, Michael, Yonemura, Shigenobu, Hisa, Yasuo, Conti, Mary Anne, Adelstein, Robert S., Sakaguchi, Hirofumi, Kachar, Bechara

“…Nonmuscle myosin II (NMII) is thought to be the master integrator of force within epithelial apical junctions, mediating epithelial tissue morphogenesis and…”
Get full text

Conditional deletion of nonmuscle myosin II-A in mouse tongue epithelium results in squamous cell carcinoma by Anne Conti, Mary, Saleh, Anthony D., Brinster, Lauren R., Cheng, Hui, Chen, Zhong, Cornelius, Shaleeka, Liu, Chengyu, Ma, Xuefei, Van Waes, Carter, Adelstein, Robert S.

“…To investigate the contribution of nonmuscle myosin II-A (NM II-A) to early cardiac development we crossed Myh9 floxed mice and Nkx2.5 cre-recombinase mice…”
Get full text

Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis by Ma, Xuefei, Jana, Siddhartha S, Conti, Mary Anne, Kawamoto, Sachiyo, Claycomb, William C, Adelstein, Robert S

“…Ablation of nonmuscle myosin (NM) II-A or NM II-B results in mouse embryonic lethality. Here, we report the results of ablating NM II-C as well as NM II-C/II-B…”
Get full text

Distinct and redundant roles of the non-muscle myosin II isoforms and functional domains by Wang, Aibing, Ma, Xuefei, Conti, Mary Anne, Adelstein, Robert S

“…We propose that the in vivo functions of NM II (non-muscle myosin II) can be divided between those that depend on the N-terminal globular motor domain and…”
Get more information

Nonmuscle myosin II moves in new directions by Conti, Mary Anne, Adelstein, Robert S

“…For many years, analyses of the role of the actomyosin cytoskeleton in many basic cellular processes have centered on actin. Increasingly, however, a number of…”
Get full text

Nonmuscle Myosin IIA Regulates Intestinal Epithelial Barrier in vivo and Plays a Protective Role During Experimental Colitis by Naydenov, Nayden G., Feygin, Alex, Wang, Dongdong, Kuemmerle, John F., Harris, Gianni, Conti, Mary Anne, Adelstein, Robert S., Ivanov, Andrei I.

“…The actin cytoskeleton is a critical regulator of intestinal mucosal barrier permeability, and the integrity of epithelial adherens junctions (AJ) and tight…”
Get full text

Nonmuscle myosin II exerts tension but does not translocate actin in vertebrate cytokinesis by Ma, Xuefei, Kovács, Mihály, Conti, Mary Anne, Wang, Aibing, Zhang, Yingfan, Sellers, James R, Adelstein, Robert S

“…During vertebrate cytokinesis it is thought that contractile ring constriction is driven by nonmuscle myosin II (NM II) translocation of antiparallel actin…”
Get full text

Concerted actions of distinct nonmuscle myosin II isoforms drive intracellular membrane remodeling in live animals by Milberg, Oleg, Shitara, Akiko, Ebrahim, Seham, Masedunskas, Andrius, Tora, Muhibullah, Tran, Duy T, Chen, Yun, Conti, Mary Anne, Adelstein, Robert S, Ten Hagen, Kelly G, Weigert, Roberto

“…Membrane remodeling plays a fundamental role during a variety of biological events. However, the dynamics and the molecular mechanisms regulating this process…”
Get full text

Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A by Zhang, Yingfan, Conti, Mary Anne, Malide, Daniela, Dong, Fan, Wang, Aibing, Shmist, Yelena A., Liu, Chengyu, Zerfas, Patricia, Daniels, Mathew P., Chan, Chi-Chao, Kozin, Elliot, Kachar, Bechara, Kelley, Michael J., Kopp, Jeffrey B., Adelstein, Robert S.

“…We have generated 3 mouse lines, each with a different mutation in the nonmuscle myosin II-A gene, Myh9 (R702C, D1424N, and E1841K). Each line develops…”
Get full text

Nonmuscle myosin II isoform and domain specificity during early mouse development by Wang, Aibing, Ma, Xuefei, Conti, Mary Anne, Liu, Chengyu, Kawamoto, Sachiyo, Adelstein, Robert S., Pollard, Thomas D.

“…Nonmuscle myosins (NMs) II-A and II-B are essential for embryonic mouse development, but their specific roles are not completely defined. Here we examine the…”
Get full text

Defects in Cell Adhesion and the Visceral Endoderm following Ablation of Nonmuscle Myosin Heavy Chain II-A in Mice by Conti, Mary Anne, Even-Ram, Sharona, Liu, Chengyu, Yamada, Kenneth M, Adelstein, Robert S

“…Previous work has shown that ablation or mutation of nonmuscle myosin heavy chain II-B (NMHC II-B) in mice results in defects in the heart and brain with death…”
Get full text

PKC412 normalizes mutation‐related keratin filament disruption and hepatic injury in mice by promoting keratin–myosin binding by Kwan, Raymond, Chen, Lu, Looi, Koksun, Tao, Guo‐Zhong, Weerasinghe, Sujith V., Snider, Natasha T., Conti, Mary Anne, Adelstein, Robert S., Xie, Qing, Omary, M. Bishr

“…Keratins, among other cytoskeletal intermediate filament proteins, are mutated at a highly conserved arginine with consequent severe disease phenotypes due to…”
Get full text

Nonmuscle Myosin II Is Required for Internalization of the Epidermal Growth Factor Receptor and Modulation of Downstream Signaling by Kim, Jong Hyun, Wang, Aibing, Conti, Mary Anne, Adelstein, Robert S.

“…Ligand-induced internalization of the epidermal growth factor receptor (EGFR) is an important process for regulating signal transduction, cellular dynamics,…”
Get full text

The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway by Chen, Zhao, Naveiras, Olaia, Balduini, Alessandra, Mammoto, Akiko, Conti, Mary Anne, Adelstein, Robert S., Ingber, Donald, Daley, George Q., Shivdasani, Ramesh A.

“…The gene implicated in the May-Hegglin anomaly and related macrothrombocytopenias, MYH9, encodes myosin-IIA, a protein that enables morphogenesis in diverse…”
Get full text

Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons by Recuenco, Mariam C, Ohmori, Tomoko, Tanigawa, Shunsuke, Taguchi, Atsuhiro, Fujimura, Sayoko, Conti, Mary Anne, Wei, Qize, Kiyonari, Hiroshi, Abe, Takaya, Adelstein, Robert S, Nishinakamura, Ryuichi

“…The kidney develops from reciprocal interactions between the metanephric mesenchyme and ureteric bud. The mesenchyme transforms into epithelia and forms…”
Get full text

Identification and Characterization of Nonmuscle Myosin II-C, a New Member of the Myosin II Family by Golomb, Eliahu, Ma, Xuefei, Jana, Siddhartha S., Preston, Yvette A., Kawamoto, Sachiyo, Shoham, Nitza G., Goldin, Ehud, Conti, Mary Anne, Sellers, James R., Adelstein, Robert S.

“…A previously unrecognized nonmuscle myosin II heavy chain (NMHC II), which constitutes a distinct branch of the nonmuscle/smooth muscle myosin II family, has…”
Get full text

Non-Muscle Myosin IIA Differentially Regulates Intestinal Epithelial Cell Restitution and Matrix Invasion by Babbin, Brian A, Koch, Stefan, Bachar, Moshe, Conti, Mary-Anne, Parkos, Charles A, Adelstein, Robert S, Nusrat, Asma, Ivanov, Andrei I

“…Epithelial cell motility is critical for self-rejuvenation of normal intestinal mucosa, wound repair, and cancer metastasis. This process is regulated by the…”
Get full text

Homeodomain-interacting Protein Kinases, a Novel Family of Co-repressors for Homeodomain Transcription Factors by Kim, Young Ho, Choi, Cheol Yong, Lee, Seung-Jae, Conti, Mary Anne, Kim, Yongsok

“…A novel family of cofactors that differentially interact with homeoproteins have been identified via a yeast two-hybrid screen. The proteins contain a…”
Get full text

Rap1 activation in collagen phagocytosis is dependent on nonmuscle myosin II-A by Arora, Pamela D, Conti, Mary Anne, Ravid, Shoshana, Sacks, David B, Kapus, Andras, Adelstein, Robert S, Bresnick, Anne R, McCulloch, Christopher A

“…Rap1 enhances integrin-mediated adhesion but the link between Rap1 activation and integrin function in collagen phagocytosis is not defined. Mass spectrometry…”
Get full text

Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain by Tullio, Antonella N., Bridgman, Paul C., Tresser, Nancy J., Chan, Chi-Chao, Conti, Mary Anne, Adelstein, Robert S., Hara, Yoshinobu

“…Ablation of nonmuscle myosin heavy chain II‐B (NMHC‐B) in mice results in severe hydrocephalus with enlargement of the lateral and third ventricles. All B‐/B‐…”
Get full text