Search Results - "Annaratone, Laura"
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Urinary exosomal microRNAs in incipient diabetic nephropathy
Published in PloS one (04-11-2013)“…MicroRNAs (miRNAs), a class of small non-protein-encoding RNAs, regulate gene expression via suppression of target mRNAs. MiRNAs are present in body fluids in…”
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2
HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast
Published in BMC cancer (04-01-2012)“…Invasive micropapillary carcinoma (IMPC) of the breast is a distinct and aggressive variant of luminal type B breast cancer that does not respond to…”
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3
Formalin fixation at low temperature better preserves nucleic acid integrity
Published in PloS one (15-06-2011)“…Fixation with formalin, a widely adopted procedure to preserve tissue samples, leads to extensive degradation of nucleic acids and thereby compromises…”
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4
The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis
Published in Nature communications (21-11-2017)“…NF-κB is a transcription factor involved in the regulation of multiple physiological and pathological cellular processes, including inflammation, cell…”
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5
PAX8–GLIS3 gene fusion is a pathognomonic genetic alteration of hyalinizing trabecular tumors of the thyroid
Published in Modern pathology (01-12-2019)“…The hyalinizing trabecular adenoma/tumor is a rare and poorly characterized follicular-derived thyroid neoplasm recently shown to harbor recurrent PAX8 – GLIS1…”
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6
FOXA1 and AR in invasive breast cancer: new findings on their co-expression and impact on prognosis in ER-positive patients
Published in BMC cancer (03-07-2018)“…The role of forkhead-box A1 (FOXA1) and Androgen receptor (AR) in breast cancer (BC) has been extensively studied. However, the prognostic role of their…”
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7
Paclitaxel-Loaded Nanosponges Inhibit Growth and Angiogenesis in Melanoma Cell Models
Published in Frontiers in pharmacology (12-07-2019)“…This study investigated the effects of free paclitaxel (PTX) and PTX-loaded in pyromellitic nanosponges (PTX-PNS) in reducing and melanoma cell growth and…”
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8
Acid-free glyoxal as a substitute of formalin for structural and molecular preservation in tissue samples
Published in PloS one (10-08-2017)“…Tissue fixation in phosphate buffered formalin (PBF) remains the standard procedure in histopathology, since it results in an optimal structural, antigenic and…”
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9
The expression of LINE1‐MET chimeric transcript identifies a subgroup of aggressive breast cancers
Published in International journal of cancer (01-12-2018)“…Demethylation of the long interspersed nuclear element (LINE‐1; L1) antisense promoter can result in transcription of neighboring sequences as for the L1‐MET…”
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10
Integrative genomic and transcriptomic analyses illuminate the ontology of HER2-low breast carcinomas
Published in Genome medicine (29-08-2022)“…The "HER2-low" nomenclature identifies breast carcinomas (BCs) displaying a HER2 score of 1+/2+ in immunohistochemistry and lacking ERBB2 amplification…”
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11
The Influence of Tissue Ischemia Time on RNA Integrity and Patient-Derived Xenografts (PDX) Engraftment Rate in a Non-Small Cell Lung Cancer (NSCLC) Biobank
Published in PloS one (05-01-2016)“…Bio-repositories are invaluable resources to implement translational cancer research and clinical programs. They represent one of the most powerful tools for…”
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12
Cold Formalin Fixation Guarantees DNA Integrity in Formalin Fixed Paraffin Embedded Tissues: Premises for a Better Quality of Diagnostic and Experimental Pathology With a Specific Impact on Breast Cancer
Published in Frontiers in oncology (19-02-2020)“…Formalin fixation and paraffin embedding (FFPE) represent the standard method to preserve tissue specimens for diagnostic pathology, however formalin fixation…”
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13
Luminal long non-coding RNAs regulated by estrogen receptor alpha in a ligand-independent manner show functional roles in breast cancer
Published in Oncotarget (19-01-2016)“…Estrogen Receptor alpha (ERα) activation by estrogenic hormones induces luminal breast cancer cell proliferation. However, ERα plays also important…”
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14
Prognostic role of PD-L1 and immune-related gene expression profiles in giant cell tumors of bone
Published in Cancer Immunology, Immunotherapy (01-09-2020)“…Giant cell tumor of bone (GCTB) is a locally aggressive and rarely metastatic tumor, with a relatively unpredictable clinical course. A retrospective series of…”
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Predictive Diagnostic Pathology in the Target Therapy Era in Breast Cancer
Published in Current drug targets (01-01-2017)“…Treatment strategies in oncology are nowadays largely based on the "target therapy model", which allows to personalize the cure of each patient depending on…”
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AR/ER Ratio Correlates with Expression of Proliferation Markers and with Distinct Subset of Breast Tumors
Published in Cells (Basel, Switzerland) (24-04-2020)“…The co-expression of androgen (AR) and estrogen (ER) receptors, in terms of higher AR/ER ratio, has been recently associated with poor outcome in ER-positive…”
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Enhanced cytotoxic effect of camptothecin nanosponges in anaplastic thyroid cancer cells in vitro and in vivo on orthotopic xenograft tumors
Published in Drug delivery (2017)“…Anaplastic carcinoma of the thyroid (ATC) is a lethal human malignant cancer with median survival of 6 months. To date, no treatment has substantially changed…”
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18
Tamoxifen Treatment of Breast Cancer Cells: Impact on Hedgehog/GLI1 Signaling
Published in International journal of molecular sciences (27-02-2016)“…The selective estrogen receptor (ER) modulator tamoxifen (TAM) has become the standard therapy for the treatment of ER+ breast cancer patients. Despite the…”
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The impact of malignant nipple discharge cytology (NDc) in surgical management of breast cancer patients
Published in PloS one (14-08-2017)“…The role of nipple discharge cytology (NDc) in the surgical management of breast cancer patients is unclear. We aimed: (i) to evaluate the effect of malignant…”
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Glycerolized Reticular Dermis as a New Human Acellular Dermal Matrix: An Exploratory Study
Published in PloS one (26-02-2016)“…Human Acellular Dermal Matrices (HADM) are employed in various reconstructive surgery procedures as scaffolds for autologous tissue regeneration. The aim of…”
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