Search Results - "Annaert, W G"

Interaction with Telencephalin and the Amyloid Precursor Protein Predicts a Ring Structure for Presenilins by Annaert, Wim G, Esselens, Cary, Baert, Veerle, Boeve, Christine, Snellings, Greet, Cupers, Philippe, Craessaerts, Katleen, De Strooper, Bart

“…The carboxyl terminus of presenilin 1 and 2 (PS1 and PS2) binds to the neuron-specific cell adhesion molecule telencephalin (TLN) in the brain. PS1 deficiency…”
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Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons by Annaert, Wim G., Levesque, Lyne, Craessaerts, Kathleen, Dierinck, Inge, Snellings, Greet, Westaway, David, St. George-Hyslop, Peter, Cordell, Barbara, Fraser, Paul, de Strooper, Bart

“…Mutations of presenilin 1 (PS1) causing Alzheimer's disease selectively increase the secretion of the amyloidogenic βA4(1-42), whereas knocking out the gene…”
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Catecholamines are present in a synaptic-like microvesicle-enriched fraction from bovine adrenal medulla by Annaert, W G, Llona, I, Backer, A C, Jacob, W A, De Potter, W P

“…"Synaptic-like microvesicles" are present in all neuroendocrine cells and cell lines. Despite their resemblance to small synaptic vesicles of the CNS, a…”
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Ultrastructural localization of B-50/growth-associated protein-43 to anterogradely transported synaptophysin-positive and calcitonin gene-related peptide-negative vesicles in the regenerating rat sciatic nerve by Verkade, P., Verkleij, A.J., Annaert, W.G., Gispen, W.H., Oestreicher, A.B.

“…The growth-associated protein-43/B-50 (B-50/GAP-43) is conveyed from the neuronal soma into the axon by fast axonal transport and moved to the nerve terminal…”
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FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction by Flood, Dorothy G, Reaume, Andrew G, Dorfman, Karen S, Lin, Yin Guo, Lang, Diane M, Trusko, Stephen P, Savage, Mary J, Annaert, Wim G, De Strooper, Bart, Siman, Robert, Scott, Richard W

“…To investigate the consequences of mutant presenilin-1 (PS-1) expression under the control of the normal PS-1 gene, a gene-targeted mouse bearing the FAD…”
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Immunocytochemical demonstration of dopamine-beta-hydroxylase and cytochrome B561 on the axonal reticulum in bovine sympathetic neurons by Quatacker, JR, Annaert, WG, Miserez, BJ, De Potter, WP

“…In sympathetic neurons the axonal reticulum can be considered an extension of the secretory pole of the Golgi apparatus. If this tubular system indeed…”
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Export of Cellubrevin from the Endoplasmic Reticulum Is Controlled by BAP31 by Annaert, Wim G., Becker, Bernd, Kistner, Ute, Reth, Michael, Jahn, Reinhard

“…Cellubrevin is a ubiquitously expressed membrane protein that is localized to endosomes throughout the endocytotic pathway and functions in constitutive…”
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Detection of sialic acid residues in the axonal reticulum of rat superior cervical ganglion cells by lectin-gold cytochemistry by Quatacker, JR, Annaert, WG, De Potter, WP

“…Highly glycosylated compounds have been demonstrated in the axonal reticulum elements of the superior cervical ganglion cells of the rat, and this is…”
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Simultaneous purification of the neuroproteins synapsin I and synaptophysin by Llona, I, Annaert, W G, De Potter, W P

“…A procedure for the simultaneous purification of synapsin I and synaptophysin from calf brain was developed. Demyelinated membranes were extracted with 2%…”
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Co-storage in large 'dense-core' vesicles of dopamine and cholecystokinin in rat striatum by Llona, I, Annaert, W G, Jacob, W, De Potter, W P

“…The subcellular localization of cholecystokinin in the striatum--an area where a high density of cholecystokinin containing terminals has been…”
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Alzheimer Amyloid Protein Precursor Is Localized in Nerve Terminal Preparations to Rab5-containing Vesicular Organelles Distinct from Those Implicated in the Synaptic Vesicle Pathway by Ikin, Annat F., Annaert, Willem G., Takei, Kohji, De Camilli, Pietro, Jahn, Reinhard, Greengard, Paul, Buxbaum, Joseph D.

“…In order to localize amyloid protein precursor (APP) in nerve terminals, we have immunoisolated vesicular organelles from nerve terminal preparations using…”
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Differences in the distribution of cytochrome b561 and synaptophysin in dog splenic nerve: a biochemical and immunocytochemical study by Annaert, W G, Quatacker, J, Llona, I, De Potter, W P

“…Compared with neurons of the CNS, the organization of the peripheral adrenergic axon and nerve terminal is more complex because two types of…”
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Rab3 is present on endosomes from bovine chromaffin cells in primary culture by Slembrouck, D, Annaert, W G, Wang, J M, Potter, W P

“…Rab3a, a small GTP-binding protein, is believed to mediate Ca2+-dependent exocytosis. Consistent with such a role was the previously reported specific…”
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Rab3 dissociation and clathrin-mediated endocytosis, two key steps in the exo-endocytotic pathway of large dense-cored vesicles in primary cultures of superior cervical ganglia by Annaert, W G, Partoens, P, Slembrouck, D, Bakker, A, Jacob, W, De Potter, W P

“…In this study we have used primary cultures of porcine superior cervical ganglia as a model system to study exo-endocytosis in sympathetic neurons. Pure…”
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Subcellular localization of synaptophysin in noradrenergic nerve terminals: a biochemical and morphological study by Annaert, W G, Llona, I, de Ridder, E, Weyns, A, Quatacker, J, de Potter, W P

“…The subcellular localization of synaptophysin was investigated in noradrenergic nerve terminals of bovine vas deferens and dog spleen and compared with…”
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Presence and subcellular localization of alpha 2-adrenoceptors in dog splenic nerve by Schoups, A A, Annaert, W G, De Potter, W P

“…Two weeks after denervation of the dog spleen, alpha 2-adrenoceptors labelled by [3H]rauwolscine were decreased to 44% of control. In splenic nerve,…”
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A Novel Flat-embedding Method to Prepare Ultrathin Cryosections from Cultured Cells in Their In Situ Orientation by Oorschot, Viola, de Wit, Heidi, Annaert, Wim G, Klumperman, Judith

“…Immunogold labeling of ultrathin cryosections provides a sensitive and quantitative method to localize proteins at the ultrastructural level. An obligatory…”
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Microtubule-dependent redistribution of the type-1 inositol 1,4,5-trisphosphate receptor in A7r5 smooth muscle cells by Vermassen, Elke, Van Acker, Kristel, Annaert, Wim G, Himpens, Bernard, Callewaert, Geert, Missiaen, Ludwig, De Smedt, Humbert, Parys, Jan B

“…In A7r5 vascular smooth muscle cells, the two expressed inositol 1,4,5-trisphosphate receptor (IP(3)R) isoforms were differentially localized. IP(3)R1 was…”
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