Search Results - "Anna-Dorothea Gorki"

Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting by Cohen, Merav, Giladi, Amir, Gorki, Anna-Dorothea, Solodkin, Dikla Gelbard, Zada, Mor, Hladik, Anastasiya, Miklosi, Andras, Salame, Tomer-Meir, Halpern, Keren Bahar, David, Eyal, Itzkovitz, Shalev, Harkany, Tibor, Knapp, Sylvia, Amit, Ido

“…Lung development and function arises from the interactions between diverse cell types and lineages. Using single-cell RNA sequencing (RNA-seq), we characterize…”
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First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment by Saluzzo, Simona, Gorki, Anna-Dorothea, Rana, Batika M.J., Martins, Rui, Scanlon, Seth, Starkl, Philipp, Lakovits, Karin, Hladik, Anastasiya, Korosec, Ana, Sharif, Omar, Warszawska, Joanna M., Jolin, Helen, Mesteri, Ildiko, McKenzie, Andrew N.J., Knapp, Sylvia

“…From birth onward, the lungs are exposed to the external environment and therefore harbor a complex immunological milieu to protect this organ from damage and…”
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Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages by Sharif, Omar, Brunner, Julia Stefanie, Korosec, Ana, Martins, Rui, Jais, Alexander, Snijder, Berend, Vogel, Andrea, Caldera, Michael, Hladik, Anastasiya, Lakovits, Karin, Saluzzo, Simona, Boehm, Benedikta, Gorki, Anna-Dorothea, Mesteri, Ildiko, Lindroos-Christensen, Josefine, Tillmann, Katharina, Stoiber, Dagmar, Menche, Jörg, Schabbauer, Gernot, Bilban, Martin, Superti-Furga, Giulio, Esterbauer, Harald, Knapp, Sylvia

“…Obesity-induced white adipose tissue (WAT) hypertrophy is associated with elevated adipose tissue macrophage (ATM) content. Overexpression of the triggering…”
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Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling by Zahalka, Sophie, Starkl, Philipp, Watzenboeck, Martin L., Farhat, Asma, Radhouani, Mariem, Deckert, Florian, Hladik, Anastasiya, Lakovits, Karin, Oberndorfer, Felicitas, Lassnig, Caroline, Strobl, Birgit, Klavins, Kristaps, Matsushita, Mai, Sanin, David E., Grzes, Katarzyna M., Pearce, Edward J., Gorki, Anna-Dorothea, Knapp, Sylvia

“…Environmental microbial triggers shape the development and functionality of the immune system. Alveolar macrophages (AMs), tissue-resident macrophages of the…”
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A neutrophil-B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4 by Gawish, Riem, Maier, Barbara, Obermayer, Georg, Watzenboeck, Martin L, Gorki, Anna-Dorothea, Quattrone, Federica, Farhat, Asma, Lakovits, Karin, Hladik, Anastasiya, Korosec, Ana, Alimohammadi, Arman, Mesteri, Ildiko, Oberndorfer, Felicitas, Oakley, Fiona, Brain, John, Boon, Louis, Lang, Irene, Binder, Christoph J, Knapp, Sylvia

“…Sepsis is a life-threatening condition characterized by uncontrolled systemic inflammation and coagulation, leading to multiorgan failure. Therapeutic options…”
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Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner by Watzenboeck, Martin L, Drobits, Barbara, Zahalka, Sophie, Gorki, Anna-Dorothea, Farhat, Asma, Quattrone, Federica, Hladik, Anastasiya, Lakovits, Karin, Richard, Gabriel M, Lederer, Therese, Strobl, Birgit, Versteeg, Gijs A, Boon, Louis, Starkl, Philipp, Knapp, Sylvia

“…Lipocalin 2 (LCN2) is a secreted glycoprotein with roles in multiple biological processes. It contributes to host defense by interference with bacterial iron…”
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Host-directed therapy with 2-deoxy-D-glucose inhibits human rhinoviruses, endemic coronaviruses, and SARS-CoV-2 by Laxmikant Wali, Michael Karbiener, Scharon Chou, Vitalii Kovtunyk, Adam Adonyi, Irene Gösler, Ximena Contreras, Delyana Stoeva, Dieter Blaas, Johannes Stöckl, Thomas R. Kreil, Guido A. Gualdoni, Anna-Dorothea Gorki

“…Rhinoviruses (RVs) and coronaviruses (CoVs) upregulate host cell metabolic pathways such as glycolysis to meet their bioenergetic demands for rapid…”
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Murine Ex Vivo Cultured Alveolar Macrophages Provide a Novel Tool to Study Tissue-Resident Macrophage Behavior and Function by Gorki, Anna-Dorothea, Symmank, Dörte, Zahalka, Sophie, Lakovits, Karin, Hladik, Anastasiya, Langer, Brigitte, Maurer, Barbara, Sexl, Veronika, Kain, Renate, Knapp, Sylvia

“…Tissue-resident macrophages are of vital importance as they preserve tissue homeostasis in all mammalian organs. Nevertheless, appropriate cell culture models…”
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Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions by Martins, Rui, Maier, Julia, Gorki, Anna-Dorothea, Huber, Kilian V M, Sharif, Omar, Starkl, Philipp, Saluzzo, Simona, Quattrone, Federica, Gawish, Riem, Lakovits, Karin, Aichinger, Michael C, Radic-Sarikas, Branka, Lardeau, Charles-Hugues, Hladik, Anastasiya, Korosec, Ana, Brown, Markus, Vaahtomeri, Kari, Duggan, Michelle, Kerjaschki, Dontscho, Esterbauer, Harald, Colinge, Jacques, Eisenbarth, Stephanie C, Decker, Thomas, Bennett, Keiryn L, Kubicek, Stefan, Sixt, Michael, Superti-Furga, Giulio, Knapp, Sylvia

“…Knapp and colleagues show that elevated heme levels following hemolysis impair the control of bacterial proliferation by inhibiting phagocytosis and migration…”
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Multi-omics profiling predicts allograft function after lung transplantation by Watzenboeck, Martin L, Gorki, Anna-Dorothea, Quattrone, Federica, Gawish, Riem, Schwarz, Stefan, Lambers, Christopher, Jaksch, Peter, Lakovits, Karin, Zahalka, Sophie, Rahimi, Nina, Starkl, Philipp, Symmank, Dörte, Artner, Tyler, Pattaroni, Céline, Fortelny, Nikolaus, Klavins, Kristaps, Frommlet, Florian, Marsland, Benjamin J, Hoetzenecker, Konrad, Widder, Stefanie, Knapp, Sylvia

“…Lung transplantation is the ultimate treatment option for patients with end-stage respiratory diseases but bears the highest mortality rate among all solid…”
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JAK-STAT signaling maintains homeostasis in T cells and macrophages by Fortelny, Nikolaus, Farlik, Matthias, Fife, Victoria, Gorki, Anna-Dorothea, Lassnig, Caroline, Maurer, Barbara, Meissl, Katrin, Dolezal, Marlies, Boccuni, Laura, Ravi Sundar Jose Geetha, Aarathy, Akagha, Mojoyinola Joanna, Karjalainen, Anzhelika, Shoebridge, Stephen, Farhat, Asma, Mann, Ulrike, Jain, Rohit, Tikoo, Shweta, Zila, Nina, Esser-Skala, Wolfgang, Krausgruber, Thomas, Sitnik, Katarzyna, Penz, Thomas, Hladik, Anastasiya, Suske, Tobias, Zahalka, Sophie, Senekowitsch, Martin, Barreca, Daniele, Halbritter, Florian, Macho-Maschler, Sabine, Weninger, Wolfgang, Neubauer, Heidi A., Moriggl, Richard, Knapp, Sylvia, Sexl, Veronika, Strobl, Birgit, Decker, Thomas, Müller, Mathias, Bock, Christoph

“…Immune cells need to sustain a state of constant alertness over a lifetime. Yet, little is known about the regulatory processes that control the fluent and…”
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Platelet p110β mediates platelet-leukocyte interaction and curtails bacterial dissemination in pneumococcal pneumonia by Schrottmaier, Waltraud Cornelia, Kral-Pointner, Julia Barbara, Salzmann, Manuel, Mussbacher, Marion, Schmuckenschlager, Anna, Pirabe, Anita, Brunnthaler, Laura, Kuttke, Mario, Maier, Barbara, Heber, Stefan, Datler, Hannes, Ekici, Yasemin, Niederreiter, Birgit, Heber, Ulrike, Blomgren, Bo, Gorki, Anna-Dorothea, Söderberg-Nauclér, Cecilia, Payrastre, Bernard, Gratacap, Marie-Pierre, Knapp, Sylvia, Schabbauer, Gernot, Assinger, Alice

“…Phosphatidylinositol 3-kinase catalytic subunit p110β is involved in tumorigenesis and hemostasis. However, it remains unclear if p110β also regulates…”
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SLC20A1 at the Interface between Macrophages and Red Blood Cells by Quattrone, Federica, Gawish, Riem, Martins, Rui, Gorki, Anna-Dorothea, Watzenboeck, Martin, Hladik, Anastasiya, Lakovits, Karin, Rebsamen, Manuele, Girardi, Enrico, Superti-Furga, Giulio, Knapp, Sylvia

“…Red blood cells (RBCs) comprise 84% of our body's cells and have the essential function of transporting oxygen from the lungs to all organs. The daily…”
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