Search Results - "Anna Turkova"
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Diagnosis of tuberculosis infection in children with a novel skin test and the traditional tuberculin skin test: An observational study
Published in PloS one (27-08-2024)“…A novel skin test-called Diaskintest (DT)-containing specific M. tuberculosis antigens is in clinical use in the Russian Federation (RF). This test may improve…”
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The Smooth Away From Expected (SAFE) non-inferiority frontier: theory and implementation with an application to the D3 trial
Published in Current controlled trials in cardiovascular medicine (25-08-2023)“…Abstract Background In a non-inferiority trial, the choice of margin depends on the expected control event risk. If the true risk differs from expected, power…”
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Evaluating pediatric tuberculosis dosing guidelines: A model-based individual data pooled analysis
Published in PLoS medicine (21-11-2023)“…The current World Health Organization (WHO) pediatric tuberculosis dosing guidelines lead to suboptimal drug exposures. Identifying factors altering the…”
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Voluntariness of consent in paediatric HIV clinical trials: a mixed-methods, cross-sectional study of participants in the CHAPAS-4 and ODYSSEY trials in Uganda
Published in BMJ open (01-03-2024)“…ObjectivesTo examine the voluntariness of consent in paediatric HIV clinical trials and the associated factors.DesignMixed-methods, cross-sectional study…”
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Levofloxacin versus placebo for the prevention of tuberculosis disease in child contacts of multidrug-resistant tuberculosis: study protocol for a phase III cluster randomised controlled trial (TB-CHAMP)
Published in Current controlled trials in cardiovascular medicine (20-12-2018)“…Multidrug-resistant (MDR) tuberculosis (TB) presents a challenge for global TB control. Treating individuals with MDR-TB infection to prevent progression to…”
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Combining factorial and multi-arm multi-stage platform designs to evaluate multiple interventions efficiently
Published in Clinical trials (London, England) (01-08-2022)“…Background Factorial designs and multi-arm multi-stage (MAMS) platform designs have many advantages, but the practical advantages and disadvantages of…”
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The hard part we often forget: providing care to children and adolescents with advanced HIV disease
Published in Journal of the International AIDS Society (01-03-2023)“…Introduction Many children and adolescents living with HIV still present with severe immunosuppression with morbidity and mortality remaining high in those…”
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Sensitive HIV-1 DNA Pol Next-Generation Sequencing for the Characterisation of Archived Antiretroviral Drug Resistance
Published in Viruses (25-08-2023)“…Modern HIV-1 treatment effectively suppresses viral amplification in people living with HIV. However, the persistence of HIV-1 DNA as proviruses integrated…”
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Weekends-off efavirenz-based antiretroviral therapy in HIV-infected children, adolescents and young adults (BREATHER): Extended follow-up results of a randomised, open-label, non-inferiority trial
Published in PloS one (23-04-2018)“…Weekends off antiretroviral therapy (ART) may help engage HIV-1-infected young people facing lifelong treatment. BREATHER showed short cycle therapy (SCT; 5…”
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Borrowing information across patient subgroups in clinical trials, with application to a paediatric trial
Published in BMC medical research methodology (20-02-2022)“…Clinical trial investigators may need to evaluate treatment effects in a specific subgroup (or subgroups) of participants in addition to reporting results of…”
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Effect of dolutegravir on folate, vitamin B12 and mean corpuscular volume levels among children and adolescents with HIV: a sub-study of the ODYSSEY randomized controlled trial
Published in Journal of the International AIDS Society (01-09-2023)“…Dolutegravir-based antiretroviral therapy (ART) is the preferred antiretroviral treatment for children and adolescents living with HIV. A large surveillance…”
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Shorter treatment for minimal tuberculosis (TB) in children (SHINE): a study protocol for a randomised controlled trial
Published in Current controlled trials in cardiovascular medicine (19-04-2018)“…Tuberculosis (TB) in children is frequently paucibacillary and non-severe forms of pulmonary TB are common. Evidence for tuberculosis treatment in children is…”
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BREATHER (PENTA 16) short-cycle therapy (SCT) (5 days on/2 days off) in young people with chronic human immunodeficiency virus infection: an open, randomised, parallel-group Phase II/III trial
Published in Health technology assessment (Winchester, England) (01-06-2016)“…For human immunodeficiency virus (HIV)-infected adolescents facing lifelong antiretroviral therapy (ART), short-cycle therapy (SCT) with long-acting agents…”
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Treatment and monitoring of children and adolescents with hepatitis C in Russia: Results from a multi-centre survey on policy and practice
Published in Journal of Virus Eradication (01-03-2022)“…Background: The Russian Federation has the largest paediatric hepatitis C virus (HCV) disease burden in the World Health Organization European region with an…”
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Reply to: “Does currently recommended maternal antiviral prophylaxis against mother-to-child transmission of hepatitis B virus require enhancement?”
Published in JHEP reports (01-11-2023)Get full text
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Treating hepatitis C virus in children: time for a new paradigm
Published in Journal of Virus Eradication (01-07-2015)“…Hepatitis C virus infection is a leading cause of liver-related morbidity and mortality. In the paediatric population, HCV infection is underdiagnosed and…”
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Prevalence, incidence, and associated risk factors of tuberculosis in children with HIV living in the UK and Ireland (CHIPS): a cohort study
Published in The lancet HIV (01-12-2015)“…Summary Background Tuberculosis is the most common serious co-infection in people living with HIV worldwide, but little is known about its incidence in…”
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HCV treatment in children and young adults with HIV/HCV co-infection in Europe
Published in Journal of Virus Eradication (01-07-2015)“…Objectives: To describe use of treatment for chronic hepatitis C virus (HCV) infection in HIV/HCV co-infected children and young people living in Europe and to…”
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Short course treatment for MDR TB: jumping the gun?
Published in Thorax (01-09-2017)Get more information
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Paediatric antiretroviral therapy challenges with emerging integrase resistance
Published in Current opinion in HIV & AIDS (01-11-2024)“…Universal antiretroviral (ART) coverage and virological suppression are fundamental to ending AIDS in children by 2030. Availability of new paediatric…”
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