Search Results - "Ann Halkier, Barbara"

An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole by Payne, Richard M. E., Xu, Deyang, Foureau, Emilien, Teto Carqueijeiro, Marta Ines Soares, Oudin, Audrey, Bernonville, Thomas Dugé de, Novak, Vlastimil, Burow, Meike, Olsen, Carl-Erik, Jones, D. Marc, Tatsis, Evangelos C., Pendle, Ali, Ann Halkier, Barbara, Geu-Flores, Fernando, Courdavault, Vincent, Nour-Eldin, Hussam Hassan, O'Connor, Sarah E.

“…Plants sequester intermediates of metabolic pathways into different cellular compartments, but the mechanisms by which these molecules are transported remain…”
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Engineering of methionine chain elongation part of glucoraphanin pathway in E. coli by Mirza, Nadia, Crocoll, Christoph, Erik Olsen, Carl, Ann Halkier, Barbara

“…The methionine-derived glucosinolate glucoraphanin is associated with the health-promoting properties of broccoli. This has developed a strong interest in…”
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Production of the Cancer-Preventive Glucoraphanin in Tobacco by Mikkelsen, Michael Dalgaard, Olsen, Carl Erik, Halkier, Barbara Ann

“…Epidemiological studies have demonstrated reduced risk of developing cancer upon consumption of diets rich in cruciferous vegetables. This chemoprevention has…”
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Biology and Biochemistry of Glucosinolates by Halkier, B.A, Gershenzon, J

“…Glucosinolates are sulfur-rich, anionic natural products that upon hydrolysis by endogenous thioglucosidases called myrosinases produce several different…”
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NRT/PTR transporters are essential for translocation of glucosinolate defence compounds to seeds by Nour-Eldin, Hussam Hassan, Andersen, Tonni Grube, Burow, Meike, Madsen, Svend Roesen, Jørgensen, Morten Egevang, Olsen, Carl Erik, Dreyer, Ingo, Hedrich, Rainer, Geiger, Dietmar, Halkier, Barbara Ann

“…Two high-affinity proton-dependent transporters of glucosinolates have been identified in Arabidopsis and termed GTR1 and GTR2; these transporters are…”
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Engineering and optimization of the 2‐phenylethylglucosinolate production in Nicotiana benthamiana by combining biosynthetic genes from Barbarea vulgaris and Arabidopsis thaliana by Wang, Cuiwei, Crocoll, Christoph, Agerbirk, Niels, Halkier, Barbara Ann

“…Summary 2‐Phenylethylglucosinolate (2PE) derived from homophenylalanine is present in plants of the Brassicales order as a defense compound. It is associated…”
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Transport of defense compounds from source to sink: lessons learned from glucosinolates by Jørgensen, Morten Egevang, Nour-Eldin, Hussam Hassan, Halkier, Barbara Ann

“…•Defense compound transporter mutants show crosstalk between synthesis and storage.•Micrografting is a powerful approach to study transport processes and…”
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De novo production of benzyl glucosinolate in Escherichia coli by Petersen, Annette, Crocoll, Christoph, Halkier, Barbara Ann

“…Microbial production of plant specialised metabolites is challenging as the biosynthetic pathways are often complex and can contain enzymes, which function is…”
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Biotechnological approaches in glucosinolate production by Petersen, Annette, Wang, Cuiwei, Crocoll, Christoph, Halkier, Barbara Ann

“…Glucosinolates (GLSs) are sulfur‐rich, amino acid‐derived defense compounds characteristic of the Brassicales order. In the past, GLSs were mostly known as…”
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The Arabidopsis NPF3 protein is a GA transporter by Tal, Iris, Zhang, Yi, Jørgensen, Morten Egevang, Pisanty, Odelia, Barbosa, Inês C. R., Zourelidou, Melina, Regnault, Thomas, Crocoll, Christoph, Erik Olsen, Carl, Weinstain, Roy, Schwechheimer, Claus, Halkier, Barbara Ann, Nour-Eldin, Hussam Hassan, Estelle, Mark, Shani, Eilon

“…Gibberellins (GAs) are plant hormones that promote a wide range of developmental processes. While GA signalling is well understood, little is known about how…”
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Changing substrate specificity and iteration of amino acid chain elongation in glucosinolate biosynthesis through targeted mutagenesis of Arabidopsis methylthioalkylmalate synthase 1 by Petersen, Annette, Hansen, Lea Gram, Mirza, Nadia, Crocoll, Christoph, Mirza, Osman, Halkier, Barbara Ann

“…Methylthioalkylmalate synthases catalyse the committing step of amino acid chain elongation in glucosinolate biosynthesis. As such, this group of enzymes plays…”
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Advances in methods for identification and characterization of plant transporter function by Larsen, Bo, Xu, Deyang, Halkier, Barbara Ann, Nour-Eldin, Hussam Hassan

“…Transport proteins are crucial for cellular function at all levels. Numerous importers and exporters facilitate transport of a diverse array of metabolites and…”
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Microbial production of indolylglucosinolate through engineering of a multi-gene pathway in a versatile yeast expression platform by Mikkelsen, Michael Dalgaard, Buron, Line Due, Salomonsen, Bo, Olsen, Carl Erik, Hansen, Bjarne Gram, Mortensen, Uffe Hasbro, Halkier, Barbara Ann

“…Epidemiological studies have shown that consumption of cruciferous vegetables, such as, broccoli and cabbages, is associated with a reduced risk of developing…”
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The emerging field of transport engineering of plant specialized metabolites by Nour-Eldin, Hussam Hassan, Halkier, Barbara Ann

“…Graphical abstract Highlights ► Transport engineering has the potential to increase nutritional value of crops. ► Transport engineering can increase yield of…”
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Reduction of antinutritional glucosinolates in Brassica oilseeds by mutation of genes encoding transporters by Nour-Eldin, Hussam Hassan, Madsen, Svend Roesen, Engelen, Steven, Jørgensen, Morten Egevang, Olsen, Carl Erik, Andersen, Jonathan Sonne, Seynnaeve, David, Verhoye, Thalia, Fulawka, Rudy, Denolf, Peter, Halkier, Barbara Ann

“…An antinutritional compound in Brassica seed meal is reduced by knocking out genes encoding transporter proteins. The nutritional value of Brassica seed meals…”
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Comparison of Genome and Plasmid-Based Engineering of Multigene Benzylglucosinolate Pathway in Saccharomyces cerevisiae by Wang, Cuiwei, Poborsky, Michal, Crocoll, Christoph, Nødvig, Christina Spuur, Mortensen, Uffe Hasbro, Halkier, Barbara Ann

“…Intake of brassicaceous vegetables such as cabbage is associated with numerous health benefits. The major defense compounds in the Brassicales order are the…”
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Metabolic Engineering in Nicotiana benthamiana Reveals Key Enzyme Functions in Arabidopsis Indole Glucosinolate Modification by Pfalz, Marina, Mikkelsen, Michael Dalgaard, Bednarek, Paweł, Olsen, Carl Erik, Halkier, Barbara Ann, Kroymann, Juergen

“…Indole glucosinolates, derived from the amino acid Trp, are plant secondary metabolites that mediate numerous biological interactions between cruciferous…”
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Complex Interplay of Three R2R3 MYB Transcription Factors Determines the Profile of Aliphatic Glucosinolates in Arabidopsis by Sønderby, Ida Elken, Burow, Meike, Rowe, Heather C, Kliebenstein, Daniel J, Halkier, Barbara Ann

“…While R2R3 MYB transcription factors are a large gene family of transcription factors within plants, comprehensive functional data in planta are still scarce…”
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Systematic engineering pinpoints a versatile strategy for the expression of functional cytochrome P450 enzymes in Escherichia coli cell factories by Poborsky, Michal, Crocoll, Christoph, Motawie, Mohammed Saddik, Halkier, Barbara Ann

“…Abstract Production of plant secondary metabolites in engineered microorganisms provides a scalable and sustainable alternative to their sourcing from nature…”
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Characterization of Arabidopsis CYP79C1 and CYP79C2 by Glucosinolate Pathway Engineering in Nicotiana benthamiana Shows Substrate Specificity Toward a Range of Aliphatic and Aromatic Amino Acids by Wang, Cuiwei, Dissing, Mads Møller, Agerbirk, Niels, Crocoll, Christoph, Halkier, Barbara Ann

“…Glucosinolates (GLSs) are amino acid-derived defense compounds characteristic of the Brassicales order. Cytochromes P450s of the CYP79 family are the entry…”
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