Search Results - "Ankathil, R"

Clinical impact of ABCC1 and ABCC2 genotypes and haplotypes in mediating imatinib resistance among chronic myeloid leukaemia patients by Au, A., Baba, A. A., Azlan, H., Norsa'adah, B., Ankathil, R.

“…Summary What is known and objective The introduction and success of imatinib mesylate (IM) has brought about a paradigm shift in chronic myeloid leukaemia…”
Get full text

P0223 CYP3A4∗ 18 and CYP3A5∗ 3 gene polymorphisms and imatinib resistance in Malaysian patients with chronic myeloid leukaemia by Ankathil, R, Zian, A.A, Nizam, Z.M, Azlan, H, Baba, A.A

“…Background Although imatinib mesylate (IM) has shown excellent efficacy as first-line therapy for treatment of chronic myeloid leukaemia (CML), resistance to…”
Get full text

OP0025 Genetic association of C480G polymorphism of SLC22A1 with clinical resistance to imatinib mesylate in Malaysian patients with chronic myeloid leukaemia by Ankathil, R, Siti Maziras, M, Ahmad Aizat, A.A, Au Zian, A, Azlan, H

“…Background Despite imatinib mesylate (IM) being the gold standard drug for treatment of chronic myeloid leukaemia (CML), a significant proportion of CML…”
Get full text

The differential metabolite profiles of acute lymphoblastic leukaemic patients treated with 6-mercaptopurine using untargeted metabolomics approach by Bannur, Z., Teh, L.K., Hennesy, T., Rosli, W.R.W., Mohamad, N., Nasir, A., Ankathil, R., Zakaria, Z.A., Baba, A., Salleh, M.Z.

“…Acute lymphoblastic leukaemia (ALL) has posed challenges to the clinician due to variable patients' responses and late diagnosis. With the advance in…”
Get full text

Chromosomal abnormalities and reproductive outcome in Malaysian couples with miscarriages by Pal, S, Ma, S O, Norhasimah, M, Suhaida, M A, Siti Mariam, I, Ankathil, R, Zilfalil, B A

“…This study was done to determine the prevalence of chromosomal abnormalities and the subsequent reproductive outcome in couples who had two or more…”
Get more information

Somatic copy-neutral loss of heterozygosity and copy number abnormalities in Malaysian sporadic colorectal carcinoma patients by Yam, Y Y, Hoh, B P, Othman, N H, Hassan, S, Yahya, M M, Zakaria, Z, Ankathil, R

“…Colorectal cancer is one of the most common cancers in many countries, including Malaysia. The accumulation of genomic alterations is an important feature of…”
Get full text

Clinical manifestations in trisomy 9 by Kannan, T. P., Hemlatha, S., Ankathil, R., Zilfalil, B. A.

“…Complete trisomy 9 is a lethal diagnosis and most fetuses diagnosed thus die prenatally or during the early postnatal period and majority of such cases have…”
Get full text

Germline BRCA1 mutation and survival analysis in familial breast cancer patients in Kerala; South India by Vinodkumar, B, Syamala, V, Abraham, E K, Balakrishnan, R, Ankathil, R

“…Mutations in breast cancer susceptibility gene BRCA1 have been identified in breast or breast/ovarian cancer families from different ethnic background. We…”
Get more information

Two cases of isochromosome 18q syndrome by Pal, S, Siti, M I, Ankathil, R, Zilfalil, B A

“…Patients with isochromosome 18q, a rare cytogenetic abnormality, also reported as Edwards syndrome, is the second most common autosomal trisomy. However, the…”
Get more information

Cytogenetic and clinical profile of Down syndrome in Northeast Malaysia by Azman, B Z, Ankathil, R, Siti Mariam, I, Suhaida, M A, Norhashimah, M, Tarmizi, A B, Nor Atifah, M A, Kannan, T P, Zilfalil, B A

“…This study was designed to evaluate the karyotype pattern, clinical features and other systemic anomalies of patients with Down syndrome in Malaysia…”
Get more information

Two cases of deletion 5p syndrome: one with paternal involvement and another with atypical presentation by Azman, B Z, Akhir, S M, Zilfalil, B A, Ankathil, R

“…We report two cases of deletion 5p or cri du chat syndrome (CdCS) with different presentations and risks of transmission: one case with paternal chromosome 5…”
Get more information

ABCB1 genetic variants in leukemias: current insights into treatment outcomes by Ankathil, Ravindran

“…Despite improvements in treatment of different types of leukemia, not all patients respond optimally for a particular treatment. Some treatments will work…”
Get full text

Screening of dystrophin gene deletions in Malaysian patients with Duchenne muscular dystrophy by Marini, M, Salmi, A A, Watihayati, M S, SMardziah, M D, Zahri, M K, Hoh, B P, Ankathil, R, Lai, P S, Zilfalil, B A

“…Duchenne Muscular Dystrophy (DMD) is an X-linked recessive genetic disorder characterized by rapidly progressive muscle weakness. The disease is caused by…”
Get full text

81P Genetic association of ABCG2 polymorphisms on triple-negative breast cancer susceptibility and prognosis by Yeoh, H.I., Md Salleh, M.S., Yahya, M.M., Nazri, W.M., Ankathil, R., Aziz, A.A. Abdul

Get full text

Deficient DNA repair capacity: a predisposing factor and high risk predictive marker in familial colorectal cancer by Ankathil, R, Jyothish, B, Madhavan, J, Nair, M K

“…Even though colorectal cancer tends to aggregate in families, there is paucity of information on the genetic determinism for familial colorectal cancer (FCRC)…”
Get more information

DNA repair proficiency: a potential marker for identification of high risk members in breast cancer families by Jyothish, B, Ankathil, R, Chandini, R, Vinodkumar, B, Sunil Nayar, G, Dinesh Roy, D, Madhavan, J, Krishnan Nair, M

“…Breast cancer is the single largest cancer and causes the high rate of cancer mortality among women. A positive family history of breast cancer is recognized…”
Get full text

Influence of CYP1A2, CYP3A5 and CYP2C19 Polymorphisms on Imatinib Mesylate Drug Responses in Three Major Asian Ethnic Groups and Variation of IM and Active Metabolite (M1) Trough Level Among Chronic Myeloid Leukemia Patients by Tan, K.-L., Gan, S.-H., Hassan, R., Abdullah, A.D., Husin, A., Baba, A.A., Ankathil, R.

Get full text

Evaluating the Impact of MRP1 and MRP2 Polymorphisms on the Pharmacoresistance to Imatinib Treatment Among CML Patients by Au, A., Baba, A.A., Goh, S.A., Wahid, F.S.A., Teh, A., Elias, M.H., Ankathil, R.

Get full text

Predictive Molecular Markers of Imatinib Resistance and Prognosis in Chronic Myeloid Leukemia Patients by Elias, M.H., Au, Z.A., Husin, A., Sulong, S., Hassan, R., Goh, A.S., Wahid, S.F.A., Baba, A.A., Ankathil, R.

Get full text

Molecular pathogenesis of chronic myelogenous leukaemia by Ankathil, R, Nair, M K

“…Chronic myelogenous leukaemia is a clonal neoplasm of the pluripotent haematopoietic stem cell which is characterized in most patients by a consistent…”
Get more information