Congenital hypothyroidism in neonates

Congenital hypothyroidism in neonates

Congenital hypothyroidism (CH) is one of the most common preventable causes of mental retardation in children and it occurs in approximately 1:2,000-1:4,000 newborns. The aim of this study is to determine the frequency of CH in neonates. This cross-sectional study was conducted in neonatal units of...

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Bibliographic Details
Published in:Indian journal of endocrinology and metabolism Vol. 18; no. 2; pp. 213 - 216
Main Authors: Anjum, Aneela, Afzal, Muhammad Faheem, Iqbal, Syed Muhammad Javed, Sultan, Muhammad Ashraf, Hanif, Asif
Format: Journal Article
Language:English
Published: India Medknow Publications and Media Pvt. Ltd 01-03-2014
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects:
Case studies
Congenital hypothyroidism
Diagnosis
Diseases
Infants (Newborn)
newborn
Original
Pregnancy, Complications of
thyroid-stimulating hormone
thyroid-stimulating hormone
Congenital hypothyroidism
newborn
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Summary:Congenital hypothyroidism (CH) is one of the most common preventable causes of mental retardation in children and it occurs in approximately 1:2,000-1:4,000 newborns. The aim of this study is to determine the frequency of CH in neonates. This cross-sectional study was conducted in neonatal units of the Department of Pediatrics Unit-I, King Edward Medical University/Mayo Hospital, Lahore and Lady Willington Hospital Lahore in 6 months (January-June 2011). Sample was collected by non-probability purposive sampling. After consent, 550 newborn were registered for the study. Demographic data and relevant history was recorded. After aseptic measures, 2-3 ml venous blood analyzed for thyroid-stimulating hormone (TSH) level by immunoradiometric assay. Treatment was started according to the individual merit as per protocol. Data was analyzed by SPSS 17 and Chi-square test was applied to find out the association of CH with different variables. The study population consisted of 550 newborns. Among 550 newborns, 4 (0.8%) newborns had elevated TSH level. CH had statistically significant association with mother's hypothyroidism (P value 0.000) and mother's drug intake during the pregnancy period (P value 0.013). CH is 0.8% in neonates. It has statistically significant association with mother's hypothyroidism and mother's drug intake during pregnancy.
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ISSN:2230-8210
2230-9500
DOI:10.4103/2230-8210.129114