Search Results - "Anjo, Sandra"

Modulation of signaling pathways by DJ-1: An updated overview by Neves, Margarida, Grãos, Mário, Anjo, Sandra I., Manadas, Bruno

“…Efforts have been made to understand the physiological and pathological role of DJ-1, a Parkinson’s disease (PD)-associated protein, to provide new insights…”
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Unveiling the Differences of Secretome of Human Bone Marrow Mesenchymal Stem Cells, Adipose Tissue-Derived Stem Cells, and Human Umbilical Cord Perivascular Cells: A Proteomic Analysis by Pires, Ana O, Mendes-Pinheiro, Barbara, Teixeira, Fábio G, Anjo, Sandra I, Ribeiro-Samy, Silvina, Gomes, Eduardo D, Serra, Sofia C, Silva, Nuno A, Manadas, Bruno, Sousa, Nuno, Salgado, Antonio J

“…The use of human mesenchymal stem cells (hMSCs) has emerged as a possible therapeutic strategy for CNS-related conditions. Research in the last decade strongly…”
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A translational view of cells' secretome analysis - from untargeted proteomics to potential circulating biomarkers by Anjo, Sandra I., Manadas, Bruno

“…The identification of circulating biomarkers capable of being used as routine for diagnosis, prognosis, risk stratification and therapeutic monitoring is still…”
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Protein precipitation of diluted samples in SDS-containing buffer with acetone leads to higher protein recovery and reproducibility in comparison with TCA/acetone approach by Santa, Cátia, Anjo, Sandra I., Manadas, Bruno

“…Proteomic approaches are extremely valuable in many fields of research, where mass spectrometry methods have gained an increasing interest, especially because…”
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Hypoxia and Hypoxia-Inducible Factor-1α Regulate Endoplasmic Reticulum Stress in Nucleus Pulposus Cells: Implications of Endoplasmic Reticulum Stress for Extracellular Matrix Secretion by Novais, Emanuel J, Choi, Hyowon, Madhu, Vedavathi, Suyama, Kaori, Anjo, Sandra I, Manadas, Bruno, Shapiro, Irving M, Salgado, António J, Risbud, Makarand V

“…Endoplasmic reticulum (ER) stress is shown to promote nucleus pulposus (NP) cell apoptosis and intervertebral disc degeneration. However, little is known about…”
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Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells by Soares, Ana Rosa, Martins-Marques, Tania, Ribeiro-Rodrigues, Teresa, Ferreira, Joao Vasco, Catarino, Steve, Pinho, Maria João, Zuzarte, Monica, Isabel Anjo, Sandra, Manadas, Bruno, P.G. Sluijter, Joost, Pereira, Paulo, Girao, Henrique

“…Intercellular communication is vital to ensure tissue and organism homeostasis and can occur directly, between neighbour cells via gap junctions (GJ), or…”
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Mass Spectrometry-Based Proteomic and Metabolomic Profiling of Serum Samples for Discovery and Validation of Tuberculosis Diagnostic Biomarker Signature by Fernandes, Ana Filipa, Gonçalves, Luís Gafeira, Bento, Maria, Anjo, Sandra I, Manadas, Bruno, Barroso, Clara, Villar, Miguel, Macedo, Rita, Simões, Maria João, Coelho, Ana Varela

“…Tuberculosis (TB) is a transmissible disease listed as one of the 10 leading causes of death worldwide (10 million infected in 2019). A swift and precise…”
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Bone marrow mesenchymal stem cells' secretome exerts neuroprotective effects in a Parkinson's disease rat model by Pinheiro, Bárbara Filipa Mendes, Anjo, Sandra I., Manadas, Bruno, da Silva, Jorge D., Marote, Ana Maria Franco Aveiro, Behie, Leo A., Teixeira, Fábio G., Salgado, A. J.

“…Parkinson's disease (PD) is characterized by a selective loss of dopamine (DA) neurons in the human midbrain causing motor dysfunctions. The exact mechanism…”
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Virulence Biomarkers of Bursaphelenchus xylophilus : A Proteomic Approach by Cardoso, Joana M S, Anjo, Sandra I, Manadas, Bruno, Silva, Hugo, Abrantes, Isabel, Nakamura, Katsunori, Fonseca, Luís

“…The pinewood nematode (PWN), , one of the most serious forest pests worldwide, is considered the causal agent of the pine wilt disease (PWD). The main host…”
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More than a simple epithelial layer: multifunctional role of echinoderm coelomic epithelium by Guatelli, Silvia, Ferrario, Cinzia, Bonasoro, Francesco, Anjo, Sandra I., Manadas, Bruno, Candia Carnevali, Maria Daniela, Varela Coelho, Ana, Sugni, Michela

“…In echinoderms, the coelomic epithelium (CE) is reportedly the source of new circulating cells (coelomocytes) as well as the provider of molecular factors such…”
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SWATH‐MS as a tool for biomarker discovery: From basic research to clinical applications by Anjo, Sandra Isabel, Santa, Cátia, Manadas, Bruno

“…In the era of quantitative proteomics, where mass spectrometry plays a pivotal role, in particular associated with the use of data‐independent acquisition, it…”
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Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency by Pereira, Sandro L, Grãos, Mário, Rodrigues, Ana Sofia, Anjo, Sandra I, Carvalho, Rui A, Oliveira, Paulo J, Arenas, Ernest, Ramalho-Santos, João

“…The mitochondrion is emerging as a key organelle in stem cell biology, acting as a regulator of stem cell pluripotency and differentiation. In this study we…”
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Endogenous Fluorescent Proteins in the Mucus of an Intertidal Polychaeta: Clues for Biotechnology by Rodrigo, Ana P, Lopes, Ana, Pereira, Ricardo, Anjo, Sandra I, Manadas, Bruno, Grosso, Ana R, Baptista, Pedro V, Fernandes, Alexandra R, Costa, Pedro M

“…The vast ocean holds many unexplored organisms with unique adaptive features that enable them to thrive in their environment. The secretion of fluorescent…”
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Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer by Coelho, Margarida, Capela, João, Anjo, Sandra I, Pacheco, João, Fernandes, Margarida Sá, Amendoeira, Isabel, Jones, John G, Raposo, Luís, Manadas, Bruno

“…Differentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of…”
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Co-Transplantation of Adipose Tissue-Derived Stromal Cells and Olfactory Ensheathing Cells for Spinal Cord Injury Repair by Gomes, Eduardo D., Mendes, Sofia Silva, Silva, Rita Catarina Assunção Ribeiro, Teixeira, Fábio Gabriel Rodrigues, Pires, Ana O., Anjo, Sandra I., Manadas, Bruno, Leite-Almeida, Hugo, Gimble, Jeffrey M., Sousa, Nuno, Lepore, Angelo C., Silva, Nuno André Martins, Salgado, A. J.

“…Patients suffering from spinal cord injury (SCI) still have a dismal prognosis. Despite all the efforts developed in this area, currently there are no…”
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Modulation of the mesenchymal stem cell secretome using computer-controlled bioreactors: impact on neuronal cell proliferation, survival and differentiation by Teixeira, Fábio Gabriel Rodrigues, Panchalingam, Krishna M., Silva, Rita Catarina Assunção Ribeiro, Serra, Sofia Cravino, Pinheiro, Bárbara Filipa Mendes, Patrício, P., Jung, Sunghoon, Anjo, Sandra I., Manadas, Bruno, Pinto, Luísa, Sousa, Nuno, Behie, Leo A., Salgado, A. J.

“…In recent years it has been shown that the therapeutic benefits of human mesenchymal stem/ stromal cells (hMSCs) in the Central Nervous System (CNS) are mainly…”
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Secretome of Undifferentiated Neural Progenitor Cells Induces Histological and Motor Improvements in a Rat Model of Parkinson's Disease by Pinheiro, Bárbara Filipa Mendes, Teixeira, Fábio Gabriel Rodrigues, Anjo, Sandra I., Manadas, Bruno, Behie, Leo A., Salgado, A. J.

“…Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results from the death of dopamine (DA) neurons. Over recent years,…”
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FA-SAT ncRNA interacts with PKM2 protein: depletion of this complex induces a switch from cell proliferation to apoptosis by Ferreira, Daniela, Escudeiro, Ana, Adega, Filomena, Anjo, Sandra I., Manadas, Bruno, Chaves, Raquel

“…FA - SAT is a highly conserved satellite DNA sequence transcribed in many Bilateria species. To disclose the cellular and functional profile of FA - SAT…”
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Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and Animal behavior in a Rat Model of Parkinson’s Disease by Teixeira, Fábio Gabriel Rodrigues, Carvalho, Miguel M., Panchalingam, K. M., Rodrigues, Ana João, Pinheiro, Bárbara Filipa Mendes, Anjo, Sandra, Manadas, Bruno, Behie, Leo A., Sousa, Nuno, Salgado, A. J.

“…Research in the last decade strongly suggests that mesenchymal stem cell (MSC)-mediated therapeutic benefits are mainly due to their secretome, which has been…”
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SWATH Mass Spectrometry Applied to Cerebrospinal Fluid Differential Proteomics: Establishment of a Sample-Specific Method by Anjo, Sandra I, Santa, Cátia, Manadas, Bruno

“…Mass spectrometry (MS) has become the gold standard method for proteomics by allowing the simultaneous identification and/or quantification of thousands of…”
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