Zinc oxide nanoparticles using plant Lawsonia inermis and their mosquitocidal, antimicrobial, anticancer applications showing moderate side effects

Microbes or parasites spread vector-borne diseases by mosquitoes without being affected themselves. Insecticides used in vector control produce a substantial problem for human health. This study synthesized zinc oxide nanoparticles (ZnO NPs) using Lawsonia inermis L. and were characterized by UV–vis...

Full description

Saved in:

Bibliographic Details
Published in:	Scientific reports Vol. 11; no. 1; pp. 8837 - 13
Main Authors:	Amuthavalli, Pandiyan, Hwang, Jiang-Shiou, Dahms, Hans-Uwe, Wang, Lan, Anitha, Jagannathan, Vasanthakumaran, Murugan, Gandhi, Arumugam Dhanesh, Murugan, Kadarkarai, Subramaniam, Jayapal, Paulpandi, Manickam, Chandramohan, Balamurugan, Singh, Shivangi
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23-04-2021 Nature Publishing Group Nature Portfolio
Subjects:	631/158 631/61 639/925 704/172 Animals Anopheles - drug effects Anopheles - growth & development Anti-Infective Agents - adverse effects Anti-Infective Agents - pharmacology Antimicrobial agents Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacology Aquatic insects Cell viability Drug development Drug Screening Assays, Antitumor E coli Hep G2 Cells Humanities and Social Sciences Humans Insecticides Larva - drug effects Lawsonia inermis Lawsonia Plant - chemistry Metal Nanoparticles - chemistry Microbial Sensitivity Tests Microscopy, Electron, Scanning Microscopy, Electron, Transmission Mosquito Control - methods Mosquitoes multidisciplinary Nanoparticles Parasites Plant Extracts - adverse effects Plant Extracts - chemistry Plant Extracts - pharmacology Predation Science Science (multidisciplinary) Side effects Spectrum Analysis - methods Vector-borne diseases X-Ray Diffraction Zinc oxide Zinc Oxide - chemistry Zinc Oxide - pharmacology Zinc oxides
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Microbes or parasites spread vector-borne diseases by mosquitoes without being affected themselves. Insecticides used in vector control produce a substantial problem for human health. This study synthesized zinc oxide nanoparticles (ZnO NPs) using Lawsonia inermis L. and were characterized by UV–vis, FT-IR, SEM with EDX, and XRD analysis. Green synthesized ZnO NPs were highly toxic against Anopheles stephensi , whose lethal concentrations values ranged from 5.494 ppm (I instar), 6.801 ppm (II instar), 9.336 ppm (III instar), 10.736 ppm (IV instar), and 12.710 ppm (pupae) in contrast to L. inermis treatment. The predation efficiency of the teleost fish Gambusia affinis and the copepod Mesocyclops aspericornis against A. stephensi was not affected by exposure at sublethal doses of ZnO NPs. The predatory potency for G. affinis was 45 (I) and 25.83% (IV), copepod M. aspericornis was 40.66 (I) and 10.8% (IV) while in an ZnO NPs contaminated environment, the predation by the fish G. affinis was boosted to 71.33 and 34.25%, and predation of the copepod M. aspericornis was 60.35 and 16.75%, respectively. ZnO NPs inhibited the growth of several microbial pathogens including the bacteria ( Escherichia coli and Bacillus subtilis ) and the fungi ( Alternaria alternate and Aspergillus flavus ), respectively. ZnO NPs decreased the cell viability of Hep-G2 with IC 50 value of 21.63 µg/mL (R 2 = 0.942; P < 0.001 ) while the concentration increased from 1.88 to 30 µg/mL. These outcomes support the use of L. inermis mediated ZnO NPs for mosquito control and drug development.
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-88164-0