Search Results - "Anishkin, A."

Mechanosensitive Channels: History, Diversity, and Mechanisms by Sukharev, S., Anishkin, A.

“…— Mechanical forces are inseparable from most cellular functions. Cell division, contraction, and adhesion generate intrinsic forces in the cells, whereas…”
Get full text

Hydration properties of mechanosensitive channel pores define the energetics of gating by Anishkin, A, Akitake, B, Kamaraju, K, Chiang, C-S, Sukharev, S

“…Opening of ion channels directly by tension in the surrounding membrane appears to be the most ancient and simple mechanism of gating. Bacterial…”
Get more information

Searching for the Molecular Arrangement of Transmembrane Ceramide Channels by Anishkin, A., Sukharev, S., Colombini, M.

“…Ceramides have been implicated in the initiation of apoptosis by permeabilizing the mitochondrial outer membrane to small proteins, including cytochrome c. In…”
Get full text

Water Dynamics and Dewetting Transitions in the Small Mechanosensitive Channel MscS by Anishkin, Andriy, Sukharev, Sergei

“…The dynamics of confined water in capillaries and nanotubes suggests that gating of ion channels may involve not only changes of the pore geometry, but also…”
Get full text

Mechanosensitive channels: what can we learn from ‘simple’ model systems? by Sukharev, Sergei, Anishkin, Andriy

“…Mechanosensitive ion channels, which convert external mechanical forces into electrical and chemical signals in cells, are diverse. Presently, there is no…”
Get full text

The "dashpot" mechanism of stretch-dependent gating in MscS by Akitake, Bradley, Anishkin, Andriy, Sukharev, Sergei

“…The crystal structure of the small conductance mechanosensitive channel (MscS) has been an invaluable tool in the search for the gating mechanism, however many…”
Get full text

Gating of the Large Mechanosensitive Channel In Situ: Estimation of the Spatial Scale of the Transition from Channel Population Responses by Chiang, Chien-Sung, Anishkin, Andriy, Sukharev, Sergei

“…Physical expansion associated with the opening of a tension-sensitive channel has the same meaning as gating charge for a voltage-gated channel. Despite…”
Get full text

Microbial mechanosensation by Anishkin, Andriy, Kung, Ching

“…Because bacterial mechanosensitive channels have been cloned, purified, crystallized and subjected to a genetic, biochemical and physical scrutiny, they have…”
Get full text

Gain-of-function mutations reveal expanded intermediate states and a sequential action of two gates in MscL by Anishkin, Andriy, Chiang, Chien-Sung, Sukharev, Sergei

“…The tension-driven gating transition in the large mechanosensitive channel MscL proceeds through detectable states of intermediate conductance…”
Get full text

Explicit Channel Conductance: Can It Be Computed? by Anishkin, Andriy, Sukharev, Sergei

“…Anishkin and Sukharev comments on Aksimentiev and Schulten's article regarding the first explicit computation of the conductance of a large membrane channel…”
Get full text

Mathematical modeling of energy coupling in mitochondria in frames of proton-chemical hypothesis by Lemeshko, V V, Anishkin, A G

“…The dependence of ATP-synthesis and mitochondria respiration rates on membrane potential was analyzed in frames of proton-chemical hypothesis of oxidative…”
Get more information

On the conformation of the COOH-terminal domain of the large mechanosensitive channel MscL by Anishkin, Andriy, Gendel, Vyacheslav, Sharifi, Neda A, Chiang, Chien-Sung, Shirinian, Lena, Guy, H Robert, Sukharev, Sergei

“…COOH-terminal (S3) domains are conserved within the MscL family of bacterial mechanosensitive channels, but their function remains unclear. The X-ray structure…”
Get full text