Search Results - "Anisenko, Andrey"

Both ATM and DNA-PK Are the Main Regulators of HIV-1 Post-Integrational DNA Repair by Anisenko, Andrey, Nefedova, Anastasiia, Agapkina, Yulia, Gottikh, Marina

“…The integration of a DNA copy of an HIV-1 RNA genome into the host genome, carried out by the viral enzyme integrase, results in the formation of…”
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Complex Relationships between HIV-1 Integrase and Its Cellular Partners by Rozina, Anna, Anisenko, Andrey, Kikhai, Tatiana, Silkina, Maria, Gottikh, Marina

“…RNA viruses, in pursuit of genome miniaturization, tend to employ cellular proteins to facilitate their replication. HIV-1, one of the most well-studied…”
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Post-Integrational DNA Repair of HIV-1 Is Associated with Activation of the DNA-PK and ATM Cellular Protein Kinases and Phosphorylation of Their Targets by Anisenko, Andrey N., Nefedova, Anastasiia A., Kireev, Igor I., Gottikh, Marina B.

“…Integration of the DNA copy of HIV-1 genome into the cellular genome results in series of damages, repair of which is critical for successful replication of…”
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Complex of HIV-1 Integrase with Cellular Ku Protein: Interaction Interface and Search for Inhibitors by Ilgova, Ekaterina, Galkin, Simon, Khrenova, Maria, Serebryakova, Marina, Gottikh, Marina, Anisenko, Andrey

“…The interaction of HIV-1 integrase and the cellular Ku70 protein is necessary for HIV replication due to its positive effect on post-integration DNA repair. We…”
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NHEJ pathway is involved in post-integrational DNA repair due to Ku70 binding to HIV-1 integrase by Knyazhanskaya, Ekaterina, Anisenko, Andrey, Shadrina, Olga, Kalinina, Anastasia, Zatsepin, Timofei, Zalevsky, Arthur, Mazurov, Dmitriy, Gottikh, Marina

“…HIV-1 integration results in genomic DNA gaps that are repaired by cellular DNA repair pathways. This step of the lentiviral life cycle remains poorly…”
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KuINins as a New Class of HIV-1 Inhibitors That Block Post-Integration DNA Repair by Anisenko, Andrey, Galkin, Simon, Mikhaylov, Andrey A, Khrenova, Maria G, Agapkina, Yulia, Korolev, Sergey, Garkul, Lidia, Shirokova, Vasilissa, Ikonnikova, Viktoria A, Korlyukov, Alexander, Dorovatovskii, Pavel, Baranov, Mikhail, Gottikh, Marina

“…Integration of HIV-1 genomic cDNA results in the formation of single-strand breaks in cellular DNA, which must be repaired for efficient viral replication…”
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Transcriptomic sequence dataset of a potential new model species for studying biomineralization Onchidoris muricata (Nudibranchia, Gastropoda, Mollusca) by Nikitenko, Ekaterina D., Borisenko, Ilya E., Anisenko, Andrey N., Vortsepneva, Elena V.

“…Onchidoris muricata is a widespread shell-less species of nudibranch molluscs, which has unique for Gastropoda skeletal elements – subepidermal calcite…”
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Transcriptome dataset of HEK293T cells depleted of one of the subunits of the DNA-PK complex: Ku70, Ku80 or DNA-PKcs by Anisenko, Andrey, Shadrina, Olga, Garanina, Irina, Gottikh, Marina

“…DNA-PK is a heterotrimeric complex that consists of Ku70 (XRCC6), Ku80 (XRCC5) and DNA-PKcs (PRKDC) subunits. The complex is a major player in the repair of…”
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Characterization of HIV-1 integrase interaction with human Ku70 protein and initial implications for drug targeting by Anisenko, Andrey N., Knyazhanskaya, Ekaterina S., Zalevsky, Artur O., Agapkina, Julia Yu, Sizov, Aleksander I., Zatsepin, Timofey S., Gottikh, Marina B.

“…Human Ku70/Ku80 protein is known to influence HIV-1 replication. One of the possible reasons may be the protection of integrase from proteasomal degradation by…”
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Human Ku70 protein binds hairpin RNA and double stranded DNA through two different sites by Anisenko, Andrey N., Knyazhanskaya, Ekaterina S., Zatsepin, Timofey S., Gottikh, Marina B.

“…Human protein Ku usually functions in the cell as a complex of two subunits, Ku70 and Ku80. The Ku heterodimer plays a key role in the non-homologous end…”
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Phosphorylation Targets of DNA-PK and Their Role in HIV-1 Replication by Anisenko, Andrey, Kan, Marina, Shadrina, Olga, Brattseva, Anna, Gottikh, Marina

“…The DNA dependent protein kinase (DNA-PK) is a trimeric nuclear complex consisting of a large protein kinase and the Ku heterodimer. The kinase activity of…”
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A qPCR assay for measuring the post-integrational DNA repair in HIV-1 replication by Anisenko, Andrey N., Knyazhanskaya, Ekaterina S., Isaguliants, Maria G., Gottikh, Marina B.

“…•A qPCR assay to measure the DNA repair efficiency in HIV-1 replication is developed.•Post-integrational DNA repair process takes 8–9 h post…”
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A Fluorescent Assay to Search for Inhibitors of HIV-1 Integrase Interactions with Human Ku70 Protein, and Its Application for Characterization of Oligonucleotide Inhibitors by Galkin, Simon, Rozina, Anna, Zalevsky, Arthur, Gottikh, Marina, Anisenko, Andrey

“…The search for compounds that can inhibit the interaction of certain viral proteins with their cellular partners is a promising trend in the development of…”
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Gene Expression-Based Signature Can Predict Sorafenib Response in Kidney Cancer by Gudkov, Alexander, Shirokorad, Valery, Kashintsev, Kirill, Sokov, Dmitriy, Nikitin, Daniil, Anisenko, Andrey, Borisov, Nicolas, Sekacheva, Marina, Gaifullin, Nurshat, Garazha, Andrew, Suntsova, Maria, Koroleva, Elena, Buzdin, Anton, Sorokin, Maksim

“…Sorafenib is a tyrosine kinase inhibitory drug with multiple molecular specificities that is approved for clinical use in second-line treatments of metastatic…”
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Transcriptome analysis of HEK 293T cells revealed different significance of the depletion of DNA-dependent protein kinase subunits, Ku70, Ku80, and DNA-PKcs by Shadrina, Olga, Garanina, Irina, Anisenko, Andrey, Kireev, Igor, Gottikh, Marina

“…DNA-dependent protein kinase (DNA-PK) is a key player in the NHEJ repair pathway. DNA-PK and its subunits, Ku70, Ku80, and catalytic subunit (DNA-PKcs), also…”
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The Role of DNA Repair Complex DNA-PK in HIV-1 Transcription by Olga Shadrina, Andrey Anisenko, Marina Gottikh

“…The human DNA-dependent protein kinase (DNA-PK), composed of the heterodimeric protein Ku and catalytic subunit DNA-PKcs, is a sensor of double-strand DNA…”
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Specific features of HIV-1 integrase inhibition by bisphosphonate derivatives by Agapkina, Julia, Yanvarev, Dmitry, Anisenko, Andrey, Korolev, Sergey, Vepsäläinen, Jouko, Kochetkov, Sergey, Gottikh, Marina

“…The integration of viral DNA into the cell genome is one of the key steps in the replication cycle of human immunodeficiency virus type 1 (HIV-1). Therefore,…”
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A new fluorometric assay for the study of DNA-binding and 3′-processing activities of retroviral integrases and its use for screening of HIV-1 integrase inhibitors by Anisenko, Andrey, Agapkina, Julia, Zatsepin, Timofei, Yanvarev, Dmitry, Gottikh, Marina

“…Fluorometry using a substrate DNA labeled with a single fluorophore (6-carboxyfluorescein) at the 3′-end of the processed strand was shown to be a useful tool…”
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Modulation of HIV-1 Integrase Activity by Single-Stranded Oligonucleotides and their Conjugates with Eosin by Korolev, Sergey, Knyazhanskaya, Ekaterina, Anisenko, Andrey, Tashlitskii, Vadim, Zatsepin, Timofei S., Gottikh, Marina, Agapkina, Julia

“…Integration of the DNA copy of the genomic RNA into an infected cell genome is one of the key steps of the replication cycle of all retroviruses. It is…”
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