Search Results - "Animati, F."

Novel anthracycline oligosaccharides: Influence of chemical modifications of the carbohydrate moiety on biological activity by CIPOLLONE, A, BERETTONI, M, MAGGI, C. A, BIGIONI, M, BINASCHI, M, CERMELE, C, MONTEAGUDO, E, OLIVIERI, L, PALOMBA, D, ANIMATI, F, GOSO, C

“…Several observations highlight the importance of the carbohydrate moiety for the biological activity of antitumoural anthracyclines. Here is reported the…”
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Synthesis of 14-fluorodoxorubicin by Berettoni, M., Cipollone, A., Olivieri, L., Palomba, D., Arcamone, F., Maggi, C.A., Animati, F.

“…Synthesis of the novel anthracycline 14-fluorodoxorubicin is described. A key step in the synthesis is the hydrolysis of 14-bromo,14-fluoro derivative 14 with…”
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Observation of Internal Monosaccharide Losses in the Collisionally Activated Dissociation Mass Spectra of Anthracycline Aminodisaccharides by Warrack, Bethanne M, Hail, Mark E, Triolo, Antonio, Animati, Fabio, Seraglia, Roberta, Traldi, Piero

“…The loss of internal monosaccharide residues from anthracycline aminodisaccharides has been studied using high and low energy collisionally activated…”
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Biochemical and pharmacological activity of novel 8-fluoroanthracyclines: influence of stereochemistry and conformation by Animati, F, Arcamone, F, Bigioni, M, Capranico, G, Caserini, C, De Cesare, M, Lombardi, P, Pratesi, G, Salvatore, C, Supino, R, Zunino, F

“…In an attempt to better understand the role of the cyclohexene ring (ring A) in the biochemical and pharmacological properties of anthracyclines related to…”
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Anthracyclines: selected new developments by Binaschi, M, Bigioni, M, Cipollone, A, Rossi, C, Goso, C, Maggi, C A, Capranico, G, Animati, F

“…Anthracycline antibiotics play an important role in cancer chemotherapy. The need for an improvement of their therapeutic index has stimulated an ongoing…”
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Synthesis and conformational preference of novel 8-fluoroanthracyclines by Lombardi, P, Animati, F, Cipollone, A, Giannini, G, Monteagudo, E, Arcamone, F

“…Analogues of daunorubicin possessing a fluorine atom at position C(8) of ring A have been synthesized with the aim of comparing their DNA-drug interaction and…”
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The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes by Temperini, Claudia, Messori, Luigi, Orioli, Pierluigi, Bugno, Cristina Di, Animati, Fabio, Ughetto, Giovanni

“…The crystal structure of the complex formed between the anthracycline antibiotic 3′‐deamino‐3′‐ hydroxy‐4′‐(O‐l‐daunosaminyl)‐4‐demethoxydoxo rubicin (MEN…”
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Croton macrostachys, a plant used in traditional medicine: purgative and inflammatory activity by Mazzanti, G, Bolle, P, Martinoli, L, Piccinelli, D, Grgurina, I, Animati, F, Mugné, Y

“…Croton macrostachys seeds are widely used in Somalia as a purgative. In the present study, pharmacologic and chemical investigations confirm the laxative…”
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Oxidative degradation of cardiotoxic anticancer anthracyclines to phthalic acids. Novel function or ferrylmyoglobin by Cartoni, Antonella, Menna, Pierantonio, Salvatorelli, Emanuela, Braghiroli, Daniela, Giampietro, Rossella, Animati, Fabio, Urbani, Andrea, Del Boccio, Piero, Minotti, Giorgio

“…We show that the pseudoperoxidase activity of ferrylmyoglobin (MbIV) promotes oxidative degradation of doxorubicin (DOX), an anticancer anthracycline known to…”
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Chronic cardiotoxicity of anticancer anthracyclines in the rat: role of secondary metabolites and reduced toxicity by a novel anthracycline with impaired metabolite formation and reactivity by Sacco, Giuseppe, Giampietro, Rossella, Salvatorelli, Emanuela, Menna, Pierantonio, Bertani, Nicoletta, Graiani, Gallia, Animati, Fabio, Goso, Cristina, Maggi, Carlo A, Manzini, Stefano, Minotti, Giorgio

“…The anticancer anthracycline doxorubicin (DOX) causes cardiomyopathy upon chronic administration. There is controversy about whether DOX acts directly or after…”
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New developments in antitumor anthracyclines by Arcamone, Federico, Animati, Fabio, Capranico, Giovanni, Lombardi, Paolo, Pratesi, Graziella, Manzini, Stefano, Supino, Rosanna, Zunino, Franco

“…Doxorubicin is a major anticancer agent introduced to extended clinical use in the early 1970s. The fulfillment of a wide program of analogue synthesis led to…”
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Anthracycline Metabolism and Toxicity in Human Myocardium: Comparisons between Doxorubicin, Epirubicin, and a Novel Disaccharide Analogue with a Reduced Level of Formation and [4Fe-4S] Reactivity of Its Secondary Alcohol Metabolite by Minotti, Giorgio, Licata, Sabrina, Saponiero, Antonella, Menna, Pierantonio, Calafiore, Antonio M, Di Giammarco, Gabriele, Liberi, Giovanni, Animati, Fabio, Cipollone, Amalia, Manzini, Stefano, Maggi, Carlo A

“…Secondary alcohol metabolites have been proposed to mediate chronic cardiotoxicity induced by doxorubicin (DOX) and other anticancer anthracyclines. In this…”
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Impairment of myocardial contractility by anticancer anthracyclines: role of secondary alcohol metabolites and evidence of reduced toxicity by a novel disaccharide analogue by Minotti, Giorgio, Parlani, Massimo, Salvatorelli, Emanuela, Menna, Pierantonio, Cipollone, Amalia, Animati, Fabio, Maggi, Carlo A, Manzini, Stefano

“…The anticancer anthracycline doxorubicin (DOX) causes cardiotoxicity. Enzymatic reduction of a side chain carbonyl group converts DOX to a secondary alcohol…”
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Topoisomerase poisoning activity of novel disaccharide anthracyclines by Guano, F, Pourquier, P, Tinelli, S, Binaschi, M, Bigioni, M, Animati, F, Manzini, S, Zunino, F, Kohlhagen, G, Pommier, Y, Capranico, G

“…Doxorubicin and idarubicin are very effective anticancer drugs in the treatment of human hematological malignancies and solid tumors. These agents are well…”
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Solution Chemistry and DNA Binding Properties of MEN 10755, A Novel Disaccharide Analogue of Doxorubicin by Messori, Luigi, Temperini, Claudia, Piccioli, Francesca, Animati, Fabio, Di Bugno, Cristina, Orioli, Pierluigi

“…The behavior under physiological conditions of MEN 10755, a novel disaccharide analogue of doxorubicin, was investigated in detail by a variety of…”
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Doxorubicin disaccharide analogue : Apoptosis-related improvement of efficacy in vivo by ARCAMONE, F, ANIMATI, F, LOMBARDI, P, MADAMI, A, MANZINI, S, MONTEAGUDO, E, POLIZZI, D, PRATESI, G, RIGHETTI, S. C, SALVATORE, C, SUPINO, R, ZUNINO, F, BERETTONI, M, BIGIONI, M, CAPRANICO, G, CASAZZA, A. M, CASERINI, C, CIPOLLONE, A, DE CESARE, M, FRANCIOTTI, M

“…Although doxorubicin remains one of the most effective agents for the treatment of solid tumors, there is an intensive effort to synthesize doxorubicin…”
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Configurational requirements of the sugar moiety for the pharmacological activity of anthracycline disaccharides by Arcamone, Federico, Animati, Fabio, Bigioni, Mario, Capranico, Giovanni, Caserini, Claudia, Cipollone, Amalia, De Cesare, Michelandrea, Ettorre, Alessandro, Guano, Fulvio, Manzini, Stefano, Monteagudo, Edith, Pratesi, Graziella, Salvatore, Carmela, Supino, Rosanna, Zunino, Franco

“…The amino sugar is recognized to be a critical determinant of the activity of anthracycline monosaccharides related to doxorubicin and daunorubicin. In an…”
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A comparative study of cellular and molecular pharmacology of doxorubicin and MEN 10755, a disaccharide analogue by Bigioni, Mario, Salvatore, Carmela, Bullo, Angela, Bellarosa, Daniela, Iafrate, Elisabetta, Animati, Fabio, Capranico, Giovanni, Goso, Cristina, Maggi, Carlo Alberto, Pratesi, Graziella, Zunino, Franco, Manzini, Stefano

“…MEN 10755 is a disaccharide anthracycline endowed with a broader spectrum of antitumour activity than doxorubicin (DOX). To investigate the cellular and…”
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Synthesis, DNA-binding properties, and antitumor activity of novel distamycin derivatives by Arcamone, F M, Animati, F, Barbieri, B, Configliacchi, E, D'Alessio, R, Geroni, C, Giuliani, F C, Lazzari, E, Menozzi, M, Mongelli, N

“…A group of potential alkylating agents have been synthesized that are structurally related to the oligopeptide antiviral antibiotic distamycin. All derivatives…”
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An unusual rearrangement of Zofenopril, a new ACE inhibitor drug: mass spectrometric and conformational studies by Cartoni, Antonella, Altamura, Maria, Animati, Fabio, Balacco, Giuseppe, Cosi, Riccardo, Ettorre, Alessandro, Madami, Andrea, Triolo, Antonio

“…Zofenopril (1) is a new ACE inhibitor, used in therapy for hypertension and post‐myocardial infarction. The protonated quasi‐molecular ion (m/z 430) of 1,…”
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