Experience with vaccine prophylaxis of hepatitis B among different groups of children

The immunological activity of different vaccines against hepatitis B was evaluated in the Hepatological Center organized on the basis of the Infectious Hospital in Tula. Newborn infants were immunized with the use of the following vaccines: Engerix B (Belgium), Combiotech (Russia), Euvax B (Aventis...

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Bibliographic Details
Published in:	Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 2; p. 42
Main Authors:	Moskovskaia, I A, Kuzina, L E, Anichkina, T V, Aleshin, I K, Ul'ianova, L A, Kuzin, S N
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-2003
Subjects:	Carrier State - immunology Drug Evaluation Female Follow-Up Studies Hepatitis B - immunology Hepatitis B - prevention & control Hepatitis B Antibodies - blood Hepatitis B Surface Antigens - blood Hepatitis B Vaccines - administration & dosage Hepatitis B Vaccines - adverse effects Hepatitis B Vaccines - immunology Humans Immunization Schedule Infant Infant, Newborn Pregnancy Russia Time Factors Vaccination Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - adverse effects Vaccines, Synthetic - immunology Russia
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Summary:	The immunological activity of different vaccines against hepatitis B was evaluated in the Hepatological Center organized on the basis of the Infectious Hospital in Tula. Newborn infants were immunized with the use of the following vaccines: Engerix B (Belgium), Combiotech (Russia), Euvax B (Aventis Pastèur, South Korea). Altogether, after the full course of immunization anti-HBs were detected in 76 children out of 81 (in 93.8%). Vaccine Engerix B, when introduced according to the schedule 0-1-2-12 months, exhibited high immunogenic properties in a group of infants born of women with persistent HBs-antigenemia. Anti-HBs at a concentration exceeding 1000 I.U./I could be detected in 84.6%. In another group of children immunized according to the schedule 0-1-6 months first with vaccine Combiotech at the age of 0 and 1 month, then (at the age of 6 months) with vaccine Euvax, the presence of postvaccinal anti HBs at protective concentration was registered in all children. After immunization against hepatitis B with the use of all above-mentioned vaccines introduced according to both schedules high immunological activity and safety of immunization were noted.
ISSN:	0372-9311