Search Results - "Angus, Steven"

Inhibition of Lapatinib-induced Kinome Reprogramming in ERBB2-positive Breast Cancer by Targeting BET Family Bromodomains by Stuhlmiller, Timothy J., Miller, Samantha M., Zawistowski, Jon S., Nakamura, Kazuhiro, Beltran, Adriana S., Duncan, James S., Angus, Steven P., Collins, Kyla A.L, Granger, Deborah A., Reuther, Rachel A., Graves, Lee M., Gomez, Shawn M., Kuan, Pei-Fen, Parker, Joel S., Chen, Xin, Sciaky, Noah, Carey, Lisa A., Earp, H. Shelton, Jin, Jian, Johnson, Gary L.

“…Therapeutics such as lapatinib that target ERBB2 often provide initial clinical benefit but resistance frequently develops. Adaptive responses leading to…”
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Internal Medicine Residency Program Directors’ Screening Practices and Perceptions About Recruitment Challenges by Angus, Steven V, Williams, Christopher M, Stewart, Emily A, Sweet, Michelle, Kisielewski, Michael, Willett, Lisa L

“…PURPOSETo examine internal medicine residency program directors’ (PDs’) screening practices and perceptions about current recruitment challenges. METHODIn…”
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Engineering a Protein Binder Specific for p38α with Interface Expansion by Hussain, Mahmud, Angus, Steven P, Kuhlman, Brian

“…Protein binding specificities can be manipulated by redesigning contacts that already exist at an interface or by expanding the interface to allow interactions…”
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Molecular Pathways: Adaptive Kinome Reprogramming in Response to Targeted Inhibition of the BRAF―MEK―ERK Pathway in Cancer by JOHNSON, Gary L, STUHLMILLER, Timothy J, ANGUS, Steven P, ZAWISTOWSKI, Jon S, GRAVES, Lee M

“…The central role of the BRAF-MEK-ERK pathway in controlling cell fate has made this pathway a primary target for deregulated activation in cancer. BRaf is…”
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The Cost-Effective Evaluation of Syncope by Angus, Steven, MD

“…Syncope is a common clinical problem that carries a high socioeconomic burden. A structured approach in the evaluation of syncope with special emphasis on a…”
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Epigenetic Mechanisms Regulating Adaptive Responses to Targeted Kinase Inhibitors in Cancer by Angus, Steven P, Zawistowski, Jon S, Johnson, Gary L

“…Although targeted inhibition of oncogenic kinase drivers has achieved remarkable patient responses in many cancers, the development of resistance has remained…”
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New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging by Brighton, Hailey E, Angus, Steven P, Bo, Tao, Roques, Jose, Tagliatela, Alicia C, Darr, David B, Karagoz, Kubra, Sciaky, Noah, Gatza, Michael L, Sharpless, Norman E, Johnson, Gary L, Bear, James E

“…Targeted therapeutics that are initially effective in cancer patients nearly invariably engender resistance at some stage, an inherent challenge in the use of…”
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Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex by Zawistowski, Jon S, Bevill, Samantha M, Goulet, Daniel R, Stuhlmiller, Timothy J, Beltran, Adriana S, Olivares-Quintero, Jose F, Singh, Darshan, Sciaky, Noah, Parker, Joel S, Rashid, Naim U, Chen, Xin, Duncan, James S, Whittle, Martin C, Angus, Steven P, Velarde, Sara Hanna, Golitz, Brian T, He, Xiaping, Santos, Charlene, Darr, David B, Gallagher, Kristalyn, Graves, Lee M, Perou, Charles M, Carey, Lisa A, Earp, H Shelton, Johnson, Gary L

“…Targeting the dysregulated BRAF-MEK-ERK pathway in cancer has increasingly emerged in clinical trial design. Despite clinical responses in specific cancers…”
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Internal Medicine Residency Program Directors’ Views of the Core Entrustable Professional Activities for Entering Residency: An Opportunity to Enhance Communication of Competency Along the Continuum by Angus, Steven V., Vu, T. Robert, Willett, Lisa L., Call, Stephanie, Halvorsen, Andrew J., Chaudhry, Saima

“…PURPOSETo examine internal medicine (IM) residency program directors’ (PDs’) perspectives on the Core Entrustable Professional Activities for Entering…”
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Compliance with CDIM-APDIM Guidelines for Department of Medicine Letters: an Opportunity to Improve Communication Across the Continuum by Ferris, Allison H., Pereira, Anne G., Angus, Steven V., Kopelman, Richard I.

“…Background With rising applications to internal medicine programs and pending changes in United States Medical Licensing Examination Step 1 score reporting,…”
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The New Internal Medicine Subinternship Curriculum Guide: a Report from the Alliance for Academic Internal Medicine by Vu, T. Robert, Ferris, Allison H., Sweet, Michelle L., Angus, Steven V., Ismail, Nadia J., Stewart, Emily, Appelbaum, Jonathan S., Kwan, Brian

“…The internal medicine (IM) subinternship has been a long-established clinical experience in the final phase of medical school deemed by key stakeholders as a…”
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Cabozantinib for neurofibromatosis type 1–related plexiform neurofibromas: a phase 2 trial by Fisher, Michael J., Shih, Chie-Schin, Rhodes, Steven D., Armstrong, Amy E., Wolters, Pamela L., Dombi, Eva, Zhang, Chi, Angus, Steven P., Johnson, Gary L., Packer, Roger J., Allen, Jeffrey C., Ullrich, Nicole J., Goldman, Stewart, Gutmann, David H., Plotkin, Scott R., Rosser, Tena, Robertson, Kent A., Widemann, Brigitte C., Smith, Abbi E., Bessler, Waylan K., He, Yongzheng, Park, Su-Jung, Mund, Julie A., Jiang, Li, Bijangi-Vishehsaraei, Khadijeh, Robinson, Coretta Thomas, Cutter, Gary R., Korf, Bruce R., Blakeley, Jaishri O., Clapp, D. Wade

“…Neurofibromatosis type 1 (NF1) plexiform neurofibromas (PNs) are progressive, multicellular neoplasms that cause morbidity and may transform to sarcoma…”
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GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer by Bevill, Samantha M, Olivares-Quintero, Jose F, Sciaky, Noah, Golitz, Brian T, Singh, Darshan, Beltran, Adriana S, Rashid, Naim U, Stuhlmiller, Timothy J, Hale, Andrew, Moorman, Nathaniel J, Santos, Charlene M, Angus, Steven P, Zawistowski, Jon S, Johnson, Gary L

“…Screening of an inhibitor library targeting kinases and epigenetic regulators identified several molecules having antiproliferative synergy with extraterminal…”
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FOXO Transcription Factors Control E2F1 Transcriptional Specificity and Apoptotic Function by SHATS, Igor, GATZA, Michael L, BEIYU LIU, ANGUS, Steven P, LINGCHONG YOU, NEVINS, Joseph R

“…The transcription factor E2F1 is a key regulator of proliferation and apoptosis but the molecular mechanisms that mediate these cell fate decisions remain…”
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Drivers of Application Inflation: A National Survey of Internal Medicine Residents by Angus, Steven V., Williams, Chris M., Kwan, Brian, Vu, T. Robert, Harris, Linda, Muntz, Marty, Pereira, Anne

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Spatial Gene-Expression Profiling Unveils Immuno-oncogenic Programs of NF1-Associated Peripheral Nerve Sheath Tumor Progression by Mitchell, Dana K, Burgess, Breanne, White, Emily E, Smith, Abbi E, Sierra Potchanant, Elizabeth A, Mang, Henry, Hickey, Brooke E, Lu, Qingbo, Qian, Shaomin, Bessler, Waylan, Li, Xiaohong, Jiang, Li, Brewster, Kylee, Temm, Constance, Horvai, Andrew, Albright, Eric A, Fishel, Melissa L, Pratilas, Christine A, Angus, Steven P, Clapp, D Wade, Rhodes, Steven D

“…Plexiform neurofibromas (PNF) are benign peripheral nerve sheath tumors (PNST) associated with neurofibromatosis type 1 (NF1). Despite similar histologic…”
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Ravidomycin Analogs from Streptomyces sp. Exhibit Altered Antimicrobial and Cytotoxic Selectivity by Park, Kyoung Jin, Maier, Sarah, Zhang, Chengqian, Dixon, Shelley A. H., Rusch, Douglas B., Pupo, Monica T., Angus, Steven P., Gerdt, Joseph P.

“…Six new ravidomycin analogs (1–4, 6, and 7) were isolated from Streptomyces sp. Am59 using UV- and LCMS-guided separation based on Global Natural Products…”
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Correction: Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma by Flint, Alyssa C, Mitchell, Dana K, Angus, Steven P, Smith, Abbi E, Bessler, Waylan, Jiang, Li, Mang, Henry, Li, Xiaohong, Lu, Qingbo, Rodriguez, Brooke, Sandusky, George E, Masters, Andi R, Zhang, Chi, Dang, Pengtao, Koenig, Jenna, Johnson, Gary L, Shen, Weihua, Liu, Jiangang, Aggarwal, Amit, Donoho, Gregory P, Willard, Melinda D, Bhagwat, Shripad V, Clapp, D Wade, Rhodes, Steven D

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High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy by Cheng, Chialin, Reis, Surya A., Adams, Emily T., Fass, Daniel M., Angus, Steven P., Stuhlmiller, Timothy J., Richardson, Jared, Olafson, Hailey, Wang, Eric T., Patnaik, Debasis, Beauchamp, Roberta L., Feldman, Danielle A., Silva, M. Catarina, Sur, Mriganka, Johnson, Gary L., Ramesh, Vijaya, Miller, Bruce L., Temple, Sally, Kosik, Kenneth S., Dickerson, Bradford C., Haggarty, Stephen J.

“…Mutations in MAPT (microtubule-associated protein tau) cause frontotemporal dementia (FTD). MAPT mutations are associated with abnormal tau phosphorylation…”
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Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma by Flint, Alyssa C, Mitchell, Dana K, Angus, Steven P, Smith, Abbi E, Bessler, Waylan, Jiang, Li, Mang, Henry, Li, Xiaohong, Lu, Qingbo, Rodriguez, Brooke, Sandusky, George E, Masters, Andi R, Zhang, Chi, Dang, Pengtao, Koenig, Jenna, Johnson, Gary L, Shen, Weihua, Liu, Jiangang, Aggarwal, Amit, Donoho, Gregory P, Willard, Melinda D, Bhagwat, Shripad V, Clapp, D Wade, Rhodes, Steven D

“…Plexiform neurofibromas (PNF) are peripheral nerve sheath tumors that cause significant morbidity in persons with neurofibromatosis type 1 (NF1), yet treatment…”
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