Search Results - "Angus, James A."

Zinc drives vasorelaxation by acting in sensory nerves, endothelium and smooth muscle by Betrie, Ashenafi H., Brock, James A., Harraz, Osama F., Bush, Ashley I., He, Guo-Wei, Nelson, Mark T., Angus, James A., Wright, Christine E., Ayton, Scott

“…Zinc, an abundant transition metal, serves as a signalling molecule in several biological systems. Zinc transporters are genetically associated with…”
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Cardiac tissue engineering in an in vivo vascularized chamber by MORRITT, Andrew N, BORTOLOTTO, Susan K, DILLEY, Rodney J, XIAOLIAN HAN, KOMPA, Andrew R, MCCOMBE, David, WRIGHT, Christine E, ITESCU, Silviu, ANGUS, James A, MORRISON, Wayne A

“…Cardiac tissue engineering offers the prospect of a novel treatment for acquired or congenital heart defects. We have created vascularized pieces of beating…”
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Estimation of the vascular resistance amplifier in the renal vascular bed in conscious hypertensive rabbits: comparison with the total peripheral vasculature by Khammy, Makhala M., Angus, James A., Wright, Christine E.

“…The vascular amplifier in hypertension is a result of structural changes in resistance arteries. We estimated the vascular amplifier hypertensive:normotensive…”
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Persistent Depression of Contractility and Vasodilation with Propofol but Not with Sevoflurane or Desflurane in Rabbits by ROYSE, Colin Forbes, LIEW, David F. L, WRIGHT, Christine E, ROYSE, Alistair G, ANGUS, James A

“…Propofol, sevoflurane, and desflurane may cause hemodynamic compromise during anesthesia and critical care management. The aim of the study was to compare…”
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Pharmacological characterisation of the CB1 receptor antagonist activity of cannabidiol in the rat vas deferens bioassay by Mazeh, Amna C., Angus, James A., Wright, Christine E.

“…Cannabidiol is increasingly considered for treatment of a wide range of medical conditions. Binding studies suggest that cannabidiol binds to CB1 receptors. In…”
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Cannabidiol selectively inhibits the contraction of rat small resistance arteries: Possible role for CGRP and voltage-gated calcium channels by Mazeh, Amna C., Angus, James A., Wright, Christine E.

“…The pharmacology of cannabidiol, the non-psychoactive major component of Cannabis sativa, is of growing interest as it becomes more widely prescribed. This…”
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The 8-hydroxyquinoline derivative, clioquinol, is an alpha-1 adrenoceptor antagonist by Betrie, Ashenafi H., Abdul-Ridha, Alaa, Hartono, Herodion, Chalmers, David K., Wright, Christine E., Scott, Daniel J., Angus, James A., Ayton, Scott

“…[Display omitted] Clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) is an antimicrobial agent whose actions as a zinc or copper ionophore and an iron chelator…”
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Vasoconstrictor Responses to Vasopressor Agents in Human Pulmonary and Radial Arteries: An In Vitro Study by Currigan, Dale A, Hughes, Richard J A, Wright, Christine E, Angus, James A, Soeding, Paul F

“…BACKGROUND:Vasopressor drugs, commonly used to treat systemic hypotension and maintain organ perfusion, may also induce regional vasoconstriction in…”
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Role of endothelin-1 clearance in the haemodynamic responses to endothelin-1 in the pulmonary and hindquarter vasculature of anaesthetised rats by Angus, James A., Wright, Christine E.

“…In the pulmonary vasculature there is clearance of endothelin-1 from the circulation mediated by endothelin ETB receptors. This study explored the haemodynamic…”
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Novel α1-adrenoceptor antagonism by the fluroquinolone antibiotic trovafloxacin by Angus, James A., Wright, Christine E.

“…Trovafloxacin, a fluroquinolone antibiotic, was recently found to be an inhibitor of pannexin-1 channels through which ATP is released as “find-me” signals in…”
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Letter by Angus and Wright Regarding Article, “Pannexin-1 Channels as an Unexpected New Target of the Antihypertensive Drug Spironolactone” by Angus, James A, Wright, Christine E

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The β2-adrenoceptor agonist bronchodilators terbutaline and orciprenaline are also weak α1-adrenoceptor antagonists by Khammy, Makhala M., Truong, Cindy Kha Han, Wright, Christine E., Angus, James A.

“…Recently, the β2-adrenoceptor agonist terbutaline was shown to have α1-adrenolytic activity in mouse isolated pulmonary arteries in vitro and to lower…”
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Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives : Novel agonists for the CB1 receptor by MOLONEY, Gerard P, ANGUS, James A, ROBERTSON, Alan D, STOERMER, Martin J, ROBINSON, Michael, WRIGHT, Christine E, MCRAE, Ken, CHRISTOPOULOS, Arthur

“…An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB(1) agonists. It is hoped that compounds of this type…”
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Pharmacology of coronary artery bypass grafts by Rosenfeldt, Franklin L, He, Guo-Wei, Buxton, Brian F, Angus, James A

“…Spasm of arterial and venous graft conduits can occur both during harvesting and after the graft is connected. Attempts to overcome spasm during harvesting by…”
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The effects of varying Mg2+ ion concentrations on contractions to the cotransmitters ATP and noradrenaline in the rat vas deferens by Mazeh, Amna C., Angus, James A., Wright, Christine E.

“…The vas deferens responds to a single electrical pulse with a biphasic contraction caused by cotransmitters ATP and noradrenaline. Removing Mg2+ (normally…”
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ATP is not involved in α1-adrenoceptor-mediated vasoconstriction in resistance arteries by Angus, James A., Wright, Christine E.

“…Recent publications suggest that α1-adrenoceptor stimulation by exogenous agonists such as phenylephrine in resistance arteries cause contraction through the…”
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Novel technique to determine the pKA of clonidine at prejunctional α2-adrenoceptors in cardiac and vascular sympathetic transmission by Angus, James A., Rajasekaran, Pravin, Wright, Christine E.

“…Analytical pharmacology draws heavily on the concept of equilibrium of agonist and silent antagonist concentrations competing at a specific receptor site. This…”
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Evidence of a Cardiovascular Function for Microtubule-Associated Protein Tau by Betrie, Ashenafi H, Ayton, Scott, Bush, Ashley I, Angus, James A, Lei, Peng, Wright, Christine E

“…Aggregation of tau protein into intracellular deposits is a pathognomonic feature of tauopathies such as Alzheimer's disease (AD) and lowering tau is a…”
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Contrasting cardiovascular properties of the µ-opioid agonists morphine and methadone in the rat by Tung, Kenneth H., Angus, James A., Wright, Christine E.

“…Morphine and methadone share the property of μ-opioid receptor agonism yet have markedly different cardiovascular actions suggesting additional properties are…”
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Synergistic and additive interactions of the cannabinoid agonist CP55,940 with μ opioid receptor and α 2 ‐adrenoceptor agonists in acute pain models in mice by Tham, Shao M, Angus, James A, Tudor, Elizabeth M, Wright, Christine E

“…Cannabinoid receptor agonists elicit analgesic effects in acute and chronic pain states via spinal and supraspinal pathways. We investigated whether the…”
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