Search Results - "Angus, G."

ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway by Moskal, Natalia, Riccio, Victoria, Bashkurov, Mikhail, Taddese, Rediet, Datti, Alessandro, Lewis, Peter N., Angus McQuibban, G.

“…The accumulation of damaged mitochondria causes the death of dopaminergic neurons. The Parkin-mediated mitophagy pathway functions to remove these mitochondria…”
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The Kappa platform for rule-based modeling by Boutillier, Pierre, Maasha, Mutaamba, Li, Xing, Medina-Abarca, Héctor F, Krivine, Jean, Feret, Jérôme, Cristescu, Ioana, Forbes, Angus G, Fontana, Walter

“…Abstract Motivation We present an overview of the Kappa platform, an integrated suite of analysis and visualization techniques for building and interactively…”
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An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets by Moskal, Natalia, Visanji, Naomi P, Gorbenko, Olena, Narasimhan, Vijay, Tyrrell, Hannah, Nash, Jess, Lewis, Peter N, McQuibban, G Angus

“…Failures in mitophagy, a process by which damaged mitochondria are cleared, results in neurodegeneration, while enhancing mitophagy promotes the survival of…”
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From jeopardy champion to drug discovery; semantic similarity artificial intelligence by Moskal, Natalia, McQuibban, G. Angus

“…We have employed artificial intelligence to streamline the small molecule drug screening pipeline and identified the cholesterol-reducing compound probucol in…”
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Is an 11 eV sterile neutrino consistent with clusters, the cosmic microwave background and modified Newtonian dynamics? by Angus, G. W.

“…In this paper, we show that if a single sterile neutrino exists such that , it can serendipitously solve all outstanding issues of the Modified Newtonian…”
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The Mitochondrial Rhomboid Protease PARL Is Regulated by PDK2 to Integrate Mitochondrial Quality Control and Metabolism by Shi, Guang, McQuibban, G. Angus

“…Mitochondrial quality control (MQC) systems are essential for mitochondrial health and normal cellular function. Dysfunction of MQC is emerging as a central…”
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ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy by Wang, Yuqing, Nartiss, Yulia, Steipe, Boris, McQuibban, G. Angus, Kim, Peter K.

“…Reactive oxygen species (ROS) have been implicated as a signal for general autophagy. Both mitochondrial-produced and exogenous ROS induce autophagosome…”
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Deubiquitinating enzymes regulate PARK2-mediated mitophagy by Wang, Yuqing, Serricchio, Mauro, Jauregui, Miluska, Shanbhag, Riya, Stoltz, Tasha, Di Paolo, Caitlin T, Kim, Peter K, McQuibban, G Angus

“…The selective degradation of mitochondria by the process of autophagy, termed mitophagy, is one of the major mechanisms of mitochondrial quality control. The…”
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A taxonomy of visualization tasks for the analysis of biological pathway data by Murray, Paul, McGee, Fintan, Forbes, Angus G

“…Understanding complicated networks of interactions and chemical components is essential to solving contemporary problems in modern biology, especially in…”
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T-Cell Autoreactivity in Type 2 Diabetes: Benign or Pathogenic, Smoke or Fire? by Jones, Angus G, Eichmann, Martin

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Dwarf spheroidals in MOND by Angus, G. W.

“…We take the line-of-sight velocity dispersions as functions of radius for eight Milky Way dwarf spheroidal galaxies and use Jeans analysis to calculate the…”
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The challenges of identifying and studying type 1 diabetes in adults by Thomas, Nicholas J., Jones, Angus G.

“…Diagnosing type 1 diabetes in adults is difficult since type 2 diabetes is the predominant diabetes type, particularly with an older age of onset…”
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Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data by Dennis, John M, Shields, Beverley M, Henley, William E, Jones, Angus G, Hattersley, Andrew T

“…Research using data-driven cluster analysis has proposed five subgroups of diabetes with differences in diabetes progression and risk of complications. We…”
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Latent Autoimmune Diabetes of Adults (LADA) Is Likely to Represent a Mixed Population of Autoimmune (Type 1) and Nonautoimmune (Type 2) Diabetes by Jones, Angus G, McDonald, Timothy J, Shields, Beverley M, Hagopian, William, Hattersley, Andrew T

“…Latent autoimmune diabetes of adults (LADA) is typically defined as a new diabetes diagnosis after 35 years of age, presenting with clinical features of type 2…”
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Comments on the notion of false positivity in measurements of autoantibodies. Reply to Grill V, Sørgjerd E, Hals I, Carlsson S [letter] by Thomas, Nicholas J., Jones, Angus G.

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The abundance of galaxy clusters in modified Newtonian dynamics: cosmological simulations with massive neutrinos by Angus, G. W., Diaferio, Antonaldo

“…We present a new particle mesh cosmological N-body code for accurately solving the modified Poisson equation of the quasi-linear formulation of modified…”
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Adult-Onset Type 1 Diabetes: Current Understanding and Challenges by Leslie, R David, Evans-Molina, Carmella, Freund-Brown, Jacquelyn, Buzzetti, Raffaella, Dabelea, Dana, Gillespie, Kathleen M, Goland, Robin, Jones, Angus G, Kacher, Mark, Phillips, Lawrence S, Rolandsson, Olov, Wardian, Jana L, Dunne, Jessica L

“…Recent epidemiological data have shown that more than half of all new cases of type 1 diabetes occur in adults. Key genetic, immune, and metabolic differences…”
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Reporting of Short-Term Clinical Outcomes After Esophagectomy: A Systematic Review by BLENCOWE, Natalie S, STRONG, Sean, MCNAIR, Angus G. K, BROOKES, Sara T, CROSBY, Tom, MICHAEL GRIFFIN, S, BLAZEBY, Jane M

“…This review summarizes reporting of complications of esophageal cancer surgery. Accurate assessment of morbidity and mortality after surgery for cancer is…”
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Strategies for promoting the well-being of postgraduate medical trainees by Kumar, Kartik, Royal, Angus G

“…Correspondence to Dr Kartik Kumar, Department of Respiratory Medicine, St Mary's Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK;…”
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What surgeons tell patients and what patients want to know before major cancer surgery: a qualitative study by McNair, Angus G K, MacKichan, F, Donovan, J L, Brookes, S T, Avery, K N L, Griffin, S M, Crosby, T, Blazeby, J M

“…The information surgeons impart to patients and information patients want about surgery for cancer is important but rarely examined. This study explored…”
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