Search Results - "Angus, Derek C"

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations by Fleischmann, Carolin, Scherag, André, Adhikari, Neill K J, Hartog, Christiane S, Tsaganos, Thomas, Schlattmann, Peter, Angus, Derek C, Reinhart, Konrad

“…Reducing the global burden of sepsis, a recognized global health challenge, requires comprehensive data on the incidence and mortality on a global scale. To…”
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The global burden of sepsis: barriers and potential solutions by Rudd, Kristina E, Kissoon, Niranjan, Limmathurotsakul, Direk, Bory, Sotharith, Mutahunga, Birungi, Seymour, Christopher W, Angus, Derek C, West, T Eoin

“…Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income…”
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Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis by Seymour, Christopher W, Kennedy, Jason N, Wang, Shu, Chang, Chung-Chou H, Elliott, Corrine F, Xu, Zhongying, Berry, Scott, Clermont, Gilles, Cooper, Gregory, Gomez, Hernando, Huang, David T, Kellum, John A, Mi, Qi, Opal, Steven M, Talisa, Victor, van der Poll, Tom, Visweswaran, Shyam, Vodovotz, Yoram, Weiss, Jeremy C, Yealy, Donald M, Yende, Sachin, Angus, Derek C

“…IMPORTANCE: Sepsis is a heterogeneous syndrome. Identification of distinct clinical phenotypes may allow more precise therapy and improve care. OBJECTIVE: To…”
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Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study by Rudd, Kristina E, Johnson, Sarah Charlotte, Agesa, Kareha M, Shackelford, Katya Anne, Tsoi, Derrick, Kievlan, Daniel Rhodes, Colombara, Danny V, Ikuta, Kevin S, Kissoon, Niranjan, Finfer, Simon, Fleischmann-Struzek, Carolin, Machado, Flavia R, Reinhart, Konrad K, Rowan, Kathryn, Seymour, Christopher W, Watson, R Scott, West, T Eoin, Marinho, Fatima, Hay, Simon I, Lozano, Rafael, Lopez, Alan D, Angus, Derek C, Murray, Christopher J L, Naghavi, Mohsen

“…Sepsis is life-threatening organ dysfunction due to a dysregulated host response to infection. It is considered a major cause of health loss, but data for the…”
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Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017 by Vincent, Jean-Louis, Sakr, Yasser, Singer, Mervyn, Martin-Loeches, Ignacio, Machado, Flavia R, Marshall, John C, Finfer, Simon, Pelosi, Paolo, Brazzi, Luca, Aditianingsih, Dita, Timsit, Jean-François, Du, Bin, Wittebole, Xavier, Máca, Jan, Kannan, Santhana, Gorordo-Delsol, Luis A, De Waele, Jan J, Mehta, Yatin, Bonten, Marc J. M, Khanna, Ashish K, Kollef, Marin, Human, Mariesa, Angus, Derek C

“…IMPORTANCE: Infection is frequent among patients in the intensive care unit (ICU). Contemporary information about the types of infections, causative pathogens,…”
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Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014 by Rhee, Chanu, Dantes, Raymund, Epstein, Lauren, Murphy, David J, Seymour, Christopher W, Iwashyna, Theodore J, Kadri, Sameer S, Angus, Derek C, Danner, Robert L, Fiore, Anthony E, Jernigan, John A, Martin, Greg S, Septimus, Edward, Warren, David K, Karcz, Anita, Chan, Christina, Menchaca, John T, Wang, Rui, Gruber, Susan, Klompas, Michael

“…IMPORTANCE: Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However,…”
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) by Singer, Mervyn, Deutschman, Clifford S, Seymour, Christopher Warren, Shankar-Hari, Manu, Annane, Djillali, Bauer, Michael, Bellomo, Rinaldo, Bernard, Gordon R, Chiche, Jean-Daniel, Coopersmith, Craig M, Hotchkiss, Richard S, Levy, Mitchell M, Marshall, John C, Martin, Greg S, Opal, Steven M, Rubenfeld, Gordon D, van der Poll, Tom, Vincent, Jean-Louis, Angus, Derek C

“…IMPORTANCE: Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in…”
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Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design by Prescott, Hallie C, Calfee, Carolyn S, Thompson, B Taylor, Angus, Derek C, Liu, Vincent X

“…Both quality improvement and clinical research efforts over the past few decades have focused on consensus definition of sepsis and acute respiratory distress…”
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The epidemiology of chronic critical illness in the United States by Kahn, Jeremy M, Le, Tri, Angus, Derek C, Cox, Christopher E, Hough, Catherine L, White, Douglas B, Yende, Sachin, Carson, Shannon S

“…The epidemiology of chronic critical illness is not well characterized. We sought to determine the prevalence, outcomes, and associated costs of chronic…”
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Sepsis: a roadmap for future research by Cohen, Jonathan, Prof, Vincent, Jean-Louis, Prof, Adhikari, Neill K J, MDCM, Machado, Flavia R, MD, Angus, Derek C, Prof, Calandra, Thierry, Prof, Jaton, Katia, PhD, Giulieri, Stefano, MD, Delaloye, Julie, MD-PhD, Opal, Steven, Prof, Tracey, Kevin, Prof, van der Poll, Tom, Prof, Pelfrene, Eric, FRCP

“…Summary Sepsis is a common and lethal syndrome: although outcomes have improved, mortality remains high. No specific anti-sepsis treatments exist; as such,…”
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A Randomized Trial of a Family-Support Intervention in Intensive Care Units by White, Douglas B, Angus, Derek C, Shields, Anne-Marie, Buddadhumaruk, Praewpannarai, Pidro, Caroline, Paner, Cynthia, Chaitin, Elizabeth, Chang, Chung-Chou H, Pike, Francis, Weissfeld, Lisa, Kahn, Jeremy M, Darby, Joseph M, Kowinsky, Amy, Martin, Susan, Arnold, Robert M

“…In a cluster-randomized trial conducted in five ICUs, a nurse-led family-support intervention did not affect surrogates’ scores for anxiety and depression 6…”
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The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study. Rationale and Design by Angus, Derek C, Berry, Scott, Lewis, Roger J, Al-Beidh, Farah, Arabi, Yaseen, van Bentum-Puijk, Wilma, Bhimani, Zahra, Bonten, Marc, Broglio, Kristine, Brunkhorst, Frank, Cheng, Allen C, Chiche, Jean-Daniel, De Jong, Menno, Detry, Michelle, Goossens, Herman, Gordon, Anthony, Green, Cameron, Higgins, Alisa M, Hullegie, Sebastiaan J, Kruger, Peter, Lamontagne, Francois, Litton, Edward, Marshall, John, McGlothlin, Anna, McGuinness, Shay, Mouncey, Paul, Murthy, Srinivas, Nichol, Alistair, O'Neill, Genevieve K, Parke, Rachael, Parker, Jane, Rohde, Gernot, Rowan, Kathryn, Turner, Anne, Young, Paul, Derde, Lennie, McArthur, Colin, Webb, Steven A

“…There is broad interest in improved methods to generate robust evidence regarding best practice, especially in settings where patient conditions are…”
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Implications of Heterogeneity of Treatment Effect for Reporting and Analysis of Randomized Trials in Critical Care by Iwashyna, Theodore J, Burke, James F, Sussman, Jeremy B, Prescott, Hallie C, Hayward, Rodney A, Angus, Derek C

“…Randomized clinical trials (RCTs) are conducted to guide clinicians' selection of therapies for individual patients. Currently, RCTs in critical care often…”
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Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559) by Hotchkiss, Richard S., Colston, Elizabeth, Yende, Sachin, Angus, Derek C., Moldawer, Lyle L., Crouser, Elliott D., Martin, Greg S., Coopersmith, Craig M., Brakenridge, Scott, Mayr, Florian B., Park, Pauline K., Ye, June, Catlett, Ian M., Girgis, Ihab G., Grasela, Dennis M.

“…OBJECTIVES:To assess for the first time the safety and pharmacokinetics of an antiprogrammed cell death-ligand 1 immune checkpoint inhibitor (BMS-936559;…”
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Association Between Hospitalization for Pneumonia and Subsequent Risk of Cardiovascular Disease by Corrales-Medina, Vicente F, Alvarez, Karina N, Weissfeld, Lisa A, Angus, Derek C, Chirinos, Julio A, Chang, Chung-Chou H, Newman, Anne, Loehr, Laura, Folsom, Aaron R, Elkind, Mitchell S, Lyles, Mary F, Kronmal, Richard A, Yende, Sachin

“…IMPORTANCE: The risk of cardiovascular disease (CVD) after infection is poorly understood. OBJECTIVE: To determine whether hospitalization for pneumonia is…”
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Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis by Evans, Idris V. R, Phillips, Gary S, Alpern, Elizabeth R, Angus, Derek C, Friedrich, Marcus E, Kissoon, Niranjan, Lemeshow, Stanley, Levy, Mitchell M, Parker, Margaret M, Terry, Kathleen M, Watson, R. Scott, Weiss, Scott L, Zimmerman, Jerry, Seymour, Christopher W

“…IMPORTANCE: The death of a pediatric patient with sepsis motivated New York to mandate statewide sepsis treatment in 2013. The mandate included a 1-hour bundle…”
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The efficacy and safety of prokinetic agents in critically ill patients receiving enteral nutrition: a systematic review and meta-analysis of randomized trials by Lewis, Kim, Alqahtani, Zuhoor, Mcintyre, Lauralyn, Almenawer, Saleh, Alshamsi, Fayez, Rhodes, Andrew, Evans, Laura, Angus, Derek C, Alhazzani, Waleed

“…Intolerance to enteral nutrition is common in critically ill adults, and may result in significant morbidity including ileus, abdominal distension, vomiting…”
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Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection by Huang, David T, Yealy, Donald M, Filbin, Michael R, Brown, Aaron M, Chang, Chung-Chou H, Doi, Yohei, Donnino, Michael W, Fine, Jonathan, Fine, Michael J, Fischer, Michelle A, Holst, John M, Hou, Peter C, Kellum, John A, Khan, Feras, Kurz, Michael C, Lotfipour, Shahram, LoVecchio, Frank, Peck-Palmer, Octavia M, Pike, Francis, Prunty, Heather, Sherwin, Robert L, Southerland, Lauren, Terndrup, Thomas, Weissfeld, Lisa A, Yabes, Jonathan, Angus, Derek C

“…Differentiating acute bacterial infection from other causes of lower respiratory tract illness is challenging. In this trial, procalcitonin was investigated as…”
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Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness by Seymour, Christopher W, Gomez, Hernando, Chang, Chung-Chou H, Clermont, Gilles, Kellum, John A, Kennedy, Jason, Yende, Sachin, Angus, Derek C

“…All of medicine aspires to be precise, where a greater understanding of individual data will lead to personalized treatment and improved outcomes. Prompted by…”
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Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab by Hotchkiss, Richard S., Colston, Elizabeth, Yende, Sachin, Crouser, Elliott D., Martin, Greg S., Albertson, Timothy, Bartz, Raquel R., Brakenridge, Scott C., Delano, Matthew J., Park, Pauline K., Donnino, Michael W., Tidswell, Mark, Mayr, Florian B., Angus, Derek C., Coopersmith, Craig M., Moldawer, Lyle L., Catlett, Ian M., Girgis, Ihab G., Ye, June, Grasela, Dennis M.

“…Purpose Sepsis-associated immunosuppression increases hospital-acquired infection and viral reactivation risk. A key underlying mechanism is programmed cell…”
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