Prebiotic Strategies to Manage Lactose Intolerance Symptoms

Lactose intolerance, which affects about 65-75% of the world's population, is caused by a genetic post-weaning deficiency of lactase, the enzyme required to digest the milk sugar lactose, called lactase non-persistence. Symptoms of lactose intolerance include abdominal pain, bloating and diarrh...

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Bibliographic Details
Published in:	Nutrients Vol. 16; no. 7; p. 1002
Main Authors:	Angima, Gloria, Qu, Yunyao, Park, Si Hong, Dallas, David C
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 29-03-2024
Subjects:	Abdominal Pain Age Bacteria beta-galactosidase Bifidobacterium Biological Evolution Biosynthesis Carbon dioxide Dairy products Development and progression Diarrhea Enzymes Fermentation Food galactooligosaccharides Glucose Humans Hydrogen hypolactasia Lactase Lactase - genetics lactase-phlorizin hydrolase Lactose Lactose intolerance Lactose Intolerance - genetics Milk Milk production Prebiotics Small intestine Weaning Eastern Europe Europe Africa galactooligosaccharides lactase-phlorizin hydrolase Bifidobacterium hypolactasia beta-galactosidase
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Summary:	Lactose intolerance, which affects about 65-75% of the world's population, is caused by a genetic post-weaning deficiency of lactase, the enzyme required to digest the milk sugar lactose, called lactase non-persistence. Symptoms of lactose intolerance include abdominal pain, bloating and diarrhea. Genetic variations, namely lactase persistence, allow some individuals to metabolize lactose effectively post-weaning, a trait thought to be an evolutionary adaptation to dairy consumption. Although lactase non-persistence cannot be altered by diet, prebiotic strategies, including the consumption of galactooligosaccharides (GOSs) and possibly low levels of lactose itself, may shift the microbiome and mitigate symptoms of lactose consumption. This review discusses the etiology of lactose intolerance and the efficacy of prebiotic approaches like GOSs and low-dose lactose in symptom management.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	2072-6643 2072-6643
DOI:	10.3390/nu16071002