Search Results - "Angelovich, Thomas A"

Inflammation‐induced foam cell formation in chronic inflammatory disease by Angelovich, Thomas A, Hearps, Anna C, Jaworowski, Anthony

“…Atherosclerosis is the leading cause of cardiovascular disease and is both a metabolic and inflammatory disease. Two models describe early events initiating…”
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How Monocytes Contribute to Increased Risk of Atherosclerosis in Virologically-Suppressed HIV-Positive Individuals Receiving Combination Antiretroviral Therapy by Jaworowski, Anthony, Hearps, Anna C, Angelovich, Thomas A, Hoy, Jennifer F

“…Combination antiretroviral therapy (ART) is effective at suppressing HIV viremia to achieve persistently undetectable levels in peripheral blood in the…”
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HIV transcription persists in the brain of virally suppressed people with HIV by Jamal Eddine, Janna, Angelovich, Thomas A, Zhou, Jingling, Byrnes, Sarah J, Tumpach, Carolin, Saraya, Nadia, Chalmers, Emily, Shepherd, Rory A, Tan, Abigail, Marinis, Stephanie, Gorry, Paul R, Estes, Jacob D, Brew, Bruce J, Lewin, Sharon R, Telwatte, Sushama, Roche, Michael, Churchill, Melissa J

“…HIV persistence in the brain is a barrier to cure, and potentially contributes to HIV-associated neurocognitive disorders. Whether HIV transcription persists…”
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Age-associated changes in monocyte and innate immune activation markers occur more rapidly in HIV infected women by Martin, Genevieve E, Gouillou, Maelenn, Hearps, Anna C, Angelovich, Thomas A, Cheng, Allen C, Lynch, Fiona, Cheng, Wan-Jung, Paukovics, Geza, Palmer, Clovis S, Novak, Richard M, Jaworowski, Anthony, Landay, Alan L, Crowe, Suzanne M

“…Aging is associated with immune dysfunction and the related development of conditions with an inflammatory pathogenesis. Some of these immune changes are also…”
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Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques by Byrnes, Sarah J, Busman-Sahay, Kathleen, Angelovich, Thomas A, Younger, Skyler, Taylor-Brill, Sol, Nekorchuk, Michael, Bondoc, Stephen, Dannay, Rachel, Terry, Margaret, Cochrane, Catherine R, Jenkins, Trisha A, Roche, Michael, Deleage, Claire, Bosinger, Steven E, Paiardini, Mirko, Brew, Bruce J, Estes, Jacob D, Churchill, Melissa J

“…HIV-associated neurocognitive disorders (HAND) affect ~40% of virally suppressed people with HIV (PWH), however, the precise viral dependent and independent…”
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Non-Human Primate Models of HIV Brain Infection and Cognitive Disorders by Byrnes, Sarah J, Angelovich, Thomas A, Busman-Sahay, Kathleen, Cochrane, Catherine R, Roche, Michael, Estes, Jacob D, Churchill, Melissa J

“…Human Immunodeficiency virus (HIV)-associated neurocognitive disorders are a major burden for people living with HIV whose viremia is stably suppressed with…”
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Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART by Crowe, Suzanne M., Angelovich, Thomas A., Butterfield, Tiffany R., Anzinger, Joshua J., Palmer, Clovis S.

“…Combined antiretroviral therapy (cART) extends the lifespan and the quality of life for HIV-infected persons but does not completely eliminate chronic immune…”
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The role of oxidative stress in HIV-associated neurocognitive disorders by Buckley, Sarah, Byrnes, Sarah, Cochrane, Catherine, Roche, Michael, Estes, Jacob D., Selemidis, Stavros, Angelovich, Thomas A., Churchill, Melissa J.

“…HIV-associated neurocognitive disorders (HAND) are a leading cause of morbidity in up to 50% of individuals living with HIV, despite effective treatment with…”
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Adaptation of the intact proviral DNA assay to a nanowell-based digital PCR platform by Tumpach, Carolin, Cochrane, Catherine R., Kim, Youry, Ong, Jesslyn, Rhodes, Ajantha, Angelovich, Thomas A., Churchill, Melissa J., Lewin, Sharon R., Telwatte, Sushama, Roche, Michael

“…Quantification of intact proviruses is a critical measurement in HIV cure studies both in vitro and in vivo . The widely adopted ‘intact proviral DNA assay’…”
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Longitudinal analysis of subtype C envelope tropism for memory CD4+ T cell subsets over the first 3 years of untreated HIV-1 infection by Gartner, Matthew J, Gorry, Paul R, Tumpach, Carolin, Zhou, Jingling, Dantanarayana, Ashanti, Chang, J. Judy, Angelovich, Thomas A, Ellenberg, Paula, Laumaea, Annemarie E, Nonyane, Molati, Moore, Penny L, Lewin, Sharon R, Churchill, Melissa J, Flynn, Jacqueline K, Roche, Michael

“…Abstract Background HIV-1 infects a wide range of CD4 + T cells with different phenotypic properties and differing expression levels of entry coreceptors. We…”
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Persistence of Activated and Adaptive-Like NK Cells in HIV + Individuals despite 2 Years of Suppressive Combination Antiretroviral Therapy by Hearps, Anna C, Agius, Paul A, Zhou, Jingling, Brunt, Samantha, Chachage, Mkunde, Angelovich, Thomas A, Cameron, Paul U, Giles, Michelle, Price, Patricia, Elliott, Julian, Jaworowski, Anthony

“…Innate immune dysfunction persists in HIV individuals despite effective combination antiretroviral therapy (cART). We recently demonstrated that an…”
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Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function by Hearps, Anna C., Martin, Genevieve E., Angelovich, Thomas A., Cheng, Wan‐Jung, Maisa, Anna, Landay, Alan L., Jaworowski, Anthony, Crowe, Suzanne M.

“…Summary Chronic inflammation in older individuals is thought to contribute to inflammatory, age‐related diseases. Human monocytes are comprised of three…”
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Intact HIV Proviruses Persist in the Brain Despite Viral Suppression with ART by Cochrane, Catherine R., Angelovich, Thomas A., Byrnes, Sarah J., Waring, Emily, Guanizo, Aleks C., Trollope, Gemma S., Zhou, Jingling, Vue, Judith, Senior, Lachlan, Wanicek, Emma, Eddine, Janna Jamal, Gartner, Matthew J., Jenkins, Trisha A., Gorry, Paul R., Brew, Bruce J., Lewin, Sharon R., Estes, Jacob D., Roche, Michael, Churchill, Melissa J.

“…Objective Human immunodeficiency virus (HIV) persistence in blood and tissue reservoirs, including the brain, is a major barrier to HIV cure and possible cause…”
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Effect of Rosuvastatin Therapy on Biomarkers of Inflammation and Immune Activation in People With Human Immunodeficiency Virus at Intermediate Cardiovascular Risk by Hearps, Anna C, Angelovich, Thomas A, Trevillyan, Janine M, Wong, Michelle E, Calmy, Alexandra, Hoy, Jennifer F, Jaworowski, Anthony

“…Abstract Background Statins may help prevent cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH) with chronic inflammation owing to…”
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HIV infection and aging of the innate immune system by Hearps, Anna C, Angelovich, Thomas A, Jaworowski, Anthony, Mills, John, Landay, Alan L, Crowe, Suzanne M

“…The increased life expectancy of HIV-infected individuals due to improved treatment has revealed an unexpected increase in non-AIDS comorbidities that are…”
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Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV by Angelovich, Thomas A, Cochrane, Catherine R, Zhou, Jingling, Tumpach, Carolin, Byrnes, Sarah J, Jamal Eddine, Janna, Waring, Emily, Busman-Sahay, Kathleen, Deleage, Claire, Jenkins, Trisha A, Hearps, Anna C, Turville, Stuart, Gorry, Paul R, Lewin, Sharon R, Brew, Bruce J, Estes, Jacob D, Roche, Michael, Churchill, Melissa J

“…Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed…”
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Monocytes from men living with HIV exhibit heightened atherogenic potential despite long-term viral suppression with antiretroviral therapy by Angelovich, Thomas A., Trevillyan, Janine M., Hoy, Jennifer F., Wong, Michelle E., Agius, Paul A., Hearps, Anna C., Jaworowski, Anthony

“…People living with HIV have an increased risk of cardiovascular disease (CVD) despite effective antiretroviral therapy (ART). Monocytes play a key role in the…”
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Low-Fouling and Biodegradable Protein-Based Particles for Thrombus Imaging by Bonnard, Thomas, Jayapadman, Anand, Putri, Jasmine A, Cui, Jiwei, Ju, Yi, Carmichael, Catherine, Angelovich, Thomas A, Cody, Stephen H, French, Shauna, Pascaud, Karline, Pearce, Hannah A, Jagdale, Shweta, Caruso, Frank, Hagemeyer, Christoph E

“…Nanomedicine holds great promise for vascular disease diagnosis and specific therapy, yet rapid sequestration by the mononuclear phagocytic system limits the…”
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HIV infection induces age-related changes to monocytes and innate immune activation in young men that persist despite combination antiretroviral therapy by HEARPS, Anna C, MAISA, Anna, CHENG, Wan-Jung, ANGELOVICH, Thomas A, LICHTFUSS, Gregor F, PALMER, Clovis S, LANDAY, Alan L, JAWOROWSKI, Anthony, CROWE, Suzanne M

“…To compare the impact of HIV infection and healthy ageing on monocyte phenotype and function and determine whether age-related changes induced by HIV are…”
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Persistence of envelopes in different CD4 + T-cell subsets in antiretroviral therapy-suppressed people with HIV by Gartner, Matthew J., Tumpach, Carolin, Dantanarayana, Ashanti, Stern, Jared, Zerbato, Jennifer M., Chang, J. Judy, Angelovich, Thomas A., Anderson, Jenny L., Symons, Jori, Deeks, Steve G., Flynn, Jacqueline K., Lewin, Sharon R., Churchill, Melissa J., Gorry, Paul R., Roche, Michael

“…Despite suppressive antiretroviral therapy (ART), HIV can persist in a diverse range of CD4+ T-cell subsets. Through longitudinal env sampling from people with…”
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