Search Results - "Angelo, Vescovi L."

Multifunctionalized hydrogels foster hNSC maturation in 3D cultures and neural regeneration in spinal cord injuries by Marchini, Amanda, Raspa, Andrea, Pugliese, Raffaele, El Malek, Marina Abd, Pastori, Valentina, Lecchi, Marzia, Vescovi, Angelo L., Gelain, Fabrizio

“…Three-dimensional cell cultures are leading the way to the fabrication of tissue-like constructs useful to developmental biology and pharmaceutical screenings…”
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The EphA2 Receptor Drives Self-Renewal and Tumorigenicity in Stem-like Tumor-Propagating Cells from Human Glioblastomas by Binda, Elena, Visioli, Alberto, Giani, Fabrizio, Lamorte, Giuseppe, Copetti, Massimiliano, Pitter, Ken L., Huse, Jason T., Cajola, Laura, Zanetti, Nadia, DiMeco, Francesco, De Filippis, Lidia, Mangiola, Annunziato, Maira, Giulio, Anile, Carmelo, De Bonis, Pasquale, Reynolds, Brent A., Pasquale, Elena B., Vescovi, Angelo L.

“…In human glioblastomas (hGBMs), tumor-propagating cells with stem-like characteristics (TPCs) represent a key therapeutic target. We found that the EphA2…”
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AQP4 Aggregation State Is a Determinant for Glioma Cell Fate by Simone, Laura, Pisani, Francesco, Mola, Maria G, De Bellis, Manuela, Merla, Giuseppe, Micale, Lucia, Frigeri, Antonio, Vescovi, Angelo L, Svelto, Maria, Nicchia, Grazia P

“…The glial water channel protein aquaporin-4 (AQP4) forms heterotetramers in the plasma membrane made of the M23-AQP4 and M1-AQP4 isoforms. The isoform ratio…”
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Mild hypoxia enhances proliferation and multipotency of human neural stem cells by Santilli, Guido, Lamorte, Giuseppe, Carlessi, Luigi, Ferrari, Daniela, Rota Nodari, Laura, Binda, Elena, Delia, Domenico, Vescovi, Angelo L, De Filippis, Lidia

“…Neural stem cells (NSCs) represent an optimal tool for studies and therapy of neurodegenerative diseases. We recently established a v-myc immortalized human…”
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NOTCH Pathway Blockade Depletes CD133‐Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts by Fan, Xing, Khaki, Leila, Zhu, Thant S., Soules, Mary E., Talsma, Caroline E., Gul, Naheed, Koh, Cheryl, Zhang, Jiangyang, Li, Yue‐Ming, Maciaczyk, Jarek, Nikkhah, Guido, DiMeco, Francesco, Piccirillo, Sara, Vescovi, Angelo L., Eberhart, Charles G.

“…Cancer stem cells (CSCs) are thought to be critical for the engraftment and long‐term growth of many tumors, including glioblastoma (GBM). The cells are at…”
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Cyclopamine‐Mediated Hedgehog Pathway Inhibition Depletes Stem‐Like Cancer Cells in Glioblastoma by Bar, Eli E., Chaudhry, Aneeka, Lin, Alex, Fan, Xing, Schreck, Karisa, Matsui, William, Piccirillo, Sara, Vescovi, Angelo L., DiMeco, Francesco, Olivi, Alessandro, Eberhart, Charles G.

“…Brain tumors can arise following deregulation of signaling pathways normally activated during brain development and may derive from neural stem cells. Given…”
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Wnt5a Drives an Invasive Phenotype in Human Glioblastoma Stem-like Cells by Binda, Elena, Visioli, Alberto, Giani, Fabrizio, Trivieri, Nadia, Palumbo, Orazio, Restelli, Silvia, Dezi, Fabio, Mazza, Tommaso, Fusilli, Caterina, Legnani, Federico, Carella, Massimo, Di Meco, Francesco, Duggal, Rohit, Vescovi, Angelo L

“…Brain invasion by glioblastoma determines prognosis, recurrence, and lethality in patients, but no master factor coordinating the invasive properties of…”
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Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma by Mastrella, Giorgia, Hou, Mengzhuo, Li, Min, Stoecklein, Veit M, Zdouc, Nina, Volmar, Marie N M, Miletic, Hrvoje, Reinhard, Sören, Herold-Mende, Christel C, Kleber, Susanne, Eisenhut, Katharina, Gargiulo, Gaetano, Synowitz, Michael, Vescovi, Angelo L, Harter, Patrick N, Penninger, Josef M, Wagner, Ernst, Mittelbronn, Michel, Bjerkvig, Rolf, Hambardzumyan, Dolores, Schüller, Ulrich, Tonn, Jörg-Christian, Radke, Josefine, Glass, Rainer, Kälin, Roland E

“…Antiangiogenic therapy of glioblastoma (GBM) with bevacizumab, a VEGFA-blocking antibody, may accelerate tumor cell invasion and induce alternative angiogenic…”
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CD90 is Identified as a Candidate Marker for Cancer Stem Cells in Primary High-Grade Gliomas Using Tissue Microarrays by He, Jintang, Liu, Yashu, Zhu, Thant, Zhu, Jianhui, DiMeco, Francesco, Vescovi, Angelo L., Heth, Jason A., Muraszko, Karin M., Fan, Xing, Lubman, David M.

“…Although CD90 has been identified as a marker for various kinds of stem cells including liver cancer stem cells (CSCs) that are responsible for tumorigenesis,…”
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AQP4-dependent glioma cell features affect the phenotype of surrounding cells via extracellular vesicles by Simone, Laura, Pisani, Francesco, Binda, Elena, Frigeri, Antonio, Vescovi, Angelo L, Svelto, Maria, Nicchia, Grazia P

“…Extracellular vesicles (EVs) are membrane-enclosed particles released systemically by all cells, including tumours. Tumour EVs have been shown to manipulate…”
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Cancer stem cells from peritumoral tissue of glioblastoma multiforme: the possible missing link between tumor development and progression by Angelucci, Cristiana, D'Alessio, Alessio, Lama, Gina, Binda, Elena, Mangiola, Annunziato, Vescovi, Angelo L, Proietti, Gabriella, Masuelli, Laura, Bei, Roberto, Fazi, Barbara, Ciafrè, Silvia Anna, Sica, Gigliola

“…In glioblastoma multiforme (GBM), cancer stem cells (CSCs) are thought to be responsible for gliomagenesis, resistance to treatment and recurrence…”
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Different states of stemness of glioblastoma stem cells sustain glioblastoma subtypes indicating novel clinical biomarkers and high-efficacy customized therapies by Visioli, Alberto, Trivieri, Nadia, Mencarelli, Gandino, Giani, Fabrizio, Copetti, Massimiliano, Palumbo, Orazio, Pracella, Riccardo, Cariglia, Maria Grazia, Barile, Chiara, Mischitelli, Luigi, Soriano, Amata Amy, Palumbo, Pietro, Legnani, Federico, DiMeco, Francesco, Gorgoglione, Leonardo, Pesole, Graziano, Vescovi, Angelo L, Binda, Elena

“…Background Glioblastoma (GBM) is the most malignant among gliomas with an inevitable lethal outcome. The elucidation of the physiology and regulation of this…”
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Growth factor independence underpins a paroxysmal, aggressive Wnt5aHigh/EphA2Low phenotype in glioblastoma stem cells, conducive to experimental combinatorial therapy by Trivieri, Nadia, Visioli, Alberto, Mencarelli, Gandino, Cariglia, Maria Grazia, Marongiu, Laura, Pracella, Riccardo, Giani, Fabrizio, Soriano, Amata Amy, Barile, Chiara, Cajola, Laura, Copetti, Massimiliano, Palumbo, Orazio, Legnani, Federico, DiMeco, Francesco, Gorgoglione, Leonardo, Vescovi, Angelo L, Binda, Elena

“…Background Glioblastoma multiforme (GBM) is an incurable tumor, with a median survival rate of only 14-15 months. Along with heterogeneity and unregulated…”
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Phenotypic variation in Aicardi-Goutières syndrome explained by cell-specific IFN-stimulated gene response and cytokine release by Cuadrado, Eloy, Michailidou, Iliana, van Bodegraven, Emma J, Jansen, Machiel H, Sluijs, Jacqueline A, Geerts, Dirk, Couraud, Pierre-Olivier, De Filippis, Lidia, Vescovi, Angelo L, Kuijpers, Taco W, Hol, Elly M

“…Aicardi-Goutières syndrome (AGS) is a monogenic inflammatory encephalopathy caused by mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, or MDA5…”
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Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells by Gallia, Gary L, Tyler, Betty M, Hann, Christine L, Siu, I-Mei, Giranda, Vincent L, Vescovi, Angelo L, Brem, Henry, Riggins, Gregory J

“…A commonly activated signaling cascade in many human malignancies, including glioblastoma multiforme, is the Akt pathway. This pathway can be activated via…”
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Identification of Cell Surface Glycoprotein Markers for Glioblastoma-Derived Stem-Like Cells Using a Lectin Microarray and LC−MS/MS Approach by He, Jintang, Liu, Yashu, Xie, Xiaolei, Zhu, Thant, Soules, Mary, DiMeco, Francesco, Vescovi, Angelo L, Fan, Xing, Lubman, David M

“…Despite progress in the treatment of glioblastoma, more than 95% of patients suffering from this disease still die within 2 years. Recent findings support the…”
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BRAFV600E mutation impinges on gut microbial markers defining novel biomarkers for serrated colorectal cancer effective therapies by Trivieri, Nadia, Pracella, Riccardo, Cariglia, Maria Grazia, Panebianco, Concetta, Parrella, Paola, Visioli, Alberto, Giani, Fabrizio, Soriano, Amata Amy, Barile, Chiara, Canistro, Giuseppe, Latiano, Tiziana Pia, Dimitri, Lucia, Bazzocchi, Francesca, Cassano, Dario, Vescovi, Angelo L, Pazienza, Valerio, Binda, Elena

“…Background Colorectal cancer (CRC) harboring BRAF.sup.V600E mutation exhibits low response to conventional therapy and poorest prognosis. Due to the emerging…”
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Glioblastoma cell growth is suppressed by disruption of fibroblast growth factor pathway signaling by Loilome, Watcharin, Joshi, Avadhut D., ap Rhys, Colette M. J., Piccirillo, Sara, Angelo, Vescovi L., Gallia, Gary L., Riggins, Gregory J.

“…The Fibroblast Growth Factor (FGF) signaling pathway is reported to stimulate glioblastoma (GBM) growth. In this work we evaluated the effect of FGF2, FGF…”
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Robust generation of oligodendrocyte progenitors from human neural stem cells and engraftment in experimental demyelination models in mice by Neri, Margherita, Maderna, Claudio, Ferrari, Daniela, Cavazzin, Chiara, Vescovi, Angelo L, Gritti, Angela

“…Cell-based therapy holds great promises for demyelinating diseases. Human-derived fetal and adult oligodendrocyte progenitors (OPC) gave encouraging results in…”
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Storage of Mutant Human SOD1 in Non-Neural Cells from the Type-1 Amyotrophic Lateral Sclerosis ratG93A Model Correlated with the Lysosomes’ Dysfunction by Bicchi, Ilaria, Morena, Francesco, Argentati, Chiara, Nodari, Laura Rota, Emiliani, Carla, Gelati, Maurizio, Vescovi, Angelo L., Martino, Sabata

“…Herein, we explored the impact of the lysosome dysfunction during the progression of Amyotrophic Lateral Sclerosis type-1 (ALS1). We conducted the study in…”
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