Search Results - "Angell, Tony D."

Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors by Hamblin, J. Nicole, Angell, Tony D.R., Ballantine, Stuart P., Cook, Caroline M., Cooper, Anthony W.J., Dawson, John, Delves, Christopher J., Jones, Paul S., Lindvall, Mika, Lucas, Fiona S., Mitchell, Charlotte J., Neu, Margarete Y., Ranshaw, Lisa E., Solanke, Yemisi E., Somers, Don O., Wiseman, Joanne O.

“…A series of pyrazolo[3,4- b]pyridine-5-carboxamides has been identified as potent inhibitors of PDE4. The SAR has been explored and these studies have…”
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Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes by Angell, Richard M., Angell, Tony D., Bamborough, Paul, Bamford, Mark J., Chung, Chun-wa, Cockerill, Stuart G., Flack, Stephen S., Jones, Katherine L., Laine, Dramane I., Longstaff, Timothy, Ludbrook, Steve, Pearson, Rosannah, Smith, Kathryn J., Smee, Penny A., Somers, Don O., Walker, Ann L.

“…The biphenyl amides (BPAs) are a series of p38α MAP kinase inhibitors. Compounds are able to bind to the kinase in either the DFG-in or DFG-out conformation,…”
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Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR by Angell, Richard M., Angell, Tony D., Bamborough, Paul, Brown, David, Brown, Murray, Buckton, Jacky B., Cockerill, Stuart G., Edwards, Chris D., Jones, Katherine L., Longstaff, Tim, Smee, Penny A., Smith, Kathryn J., Somers, Don O., Walker, Ann L., Willson, Malcolm

“…Structure–activity relationships of the biphenyl amide (BPA) series against p38α are discussed with reference to the X-ray crystal structure of an example. The…”
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