Search Results - "Angelini, G. D."

Inflammatory response and cardioprotection during open‐heart surgery: the importance of anaesthetics by Suleiman, M‐S, Zacharowski, K, Angelini, G D

“…Open‐heart surgery triggers an inflammatory response that is largely the result of surgical trauma, cardiopulmonary bypass, and organ reperfusion injury (e.g…”
Get full text

Inadequate Blood Glucose Control Is Associated With In-Hospital Mortality and Morbidity in Diabetic and Nondiabetic Patients Undergoing Cardiac Surgery by ASCIONE, R, ROGERS, C. A, RAJAKARUNA, C, ANGELINI, G. D

“…Derangement of glucose metabolism after surgery is not specific to patients with diabetes mellitus. We investigated the effect of different degrees of blood…”
Get full text

Side effects of cardiopulmonary bypass: what is the reality? by Murphy, G J, Angelini, G D

“…Despite many years of clinical and experimental research, the contribution of cardiopulmonary bypass (CPB) and cardioplegic arrest to morbidity and mortality…”
Get full text

Risk factors for and economic implications of prolonged ventilation after cardiac surgery by Rajakaruna, C., Rogers, C.A., Angelini, G.D., Ascione, R.

“…The study’s objective was to identify predictors of prolonged ventilation and assess clinical and cost implications in patients undergoing cardiac surgery…”
Get full text

importance of myocardial amino acids during ischemia and reperfusion in dilated left ventricle of patients with degenerative mitral valve disease by Venturini, A, Ascione, R, Lin, H, Polesel, E, Angelini, G. D, Suleiman, M.-S

“…Taurine, glutamine, glutamate, aspartate, and alanine are the most abundant intracellular free amino acids in human heart. The myocardial concentration of…”
Get full text

Age-dependent and hypoxia-related differences in myocardial protection during pediatric open heart surgery by IMURA, H, CAPUTO, M, PARRY, A, PAWADE, A, ANGELINI, G. D, SULEIMAN, M.-S

“…Current cardioplegic protection techniques used in pediatric cardiac surgery do not take into consideration age and cyanotic differences. The aim of the…”
Get full text

Superoxide from NADPH oxidase upregulates type 5 phosphodiesterase in human vascular smooth muscle cells: inhibition with iloprost and NONOate by Muzaffar, S, Shukla, N, Bond, M, Sala‐Newby, G B, Newby, A C, Angelini, G D, Jeremy, J Y

“…Background and purpose: To determine whether there is an association between vascular NADPH oxidase (NOX), superoxide, the small GTPase Rac1 and PDE type 5…”
Get full text

Cardioplegic strategies to protect the hypertrophic heart during cardiac surgery by Suleiman, M-S, Hancock, M, Shukla, R, Rajakaruna, C, Angelini, GD

“…Cardioplegic arrest and cardiopulmonary bypass are key triggers of myocardial injury during aortic valve surgery. Cardioplegic ischaemic arrest is associated…”
Get full text

Role of the endothelium and nitric oxide synthases in modulating superoxide formation induced by endotoxin and cytokines in porcine pulmonary arteries by Muzaffar, S, Jeremy, J Y, Angelini, G D, Stuart-Smith, K, Shukla, N

“…Background: The interactive roles of cytokines, endotoxins, superoxide (O2• − ) and nitric oxide (NO) in the pathogenesis of adult respiratory distress…”
Get full text

Reactive oxygen species and erectile dysfunction: possible role of NADPH oxidase by JEREMY, J. Y, JONES, R. A, KOUPPARIS, A. J, HOTSTON, M, PERSAD, R, ANGELINI, G. D, SHUKLA, N

“…Erectile dysfunction (ED) is a widespread condition, the incidence of which is increasing globally. ED is also indicative of underlying vasculopathy and…”
Get full text

Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery by Zakkar, M, Ascione, R, James, A F, Angelini, G D, Suleiman, M S

“…Postoperative atrial fibrillation (POAF) is a common complication of cardiac surgery that occurs in up to 60% of patients. POAF is associated with increased…”
Get full text

Myocardial metabolic changes during pediatric cardiac surgery: A randomized study of 3 cardioplegic techniques by Modi, P, Suleiman, M.-S, Reeves, B, Pawade, A, Parry, A.J, Angelini, G.D, Caputo, M

“…Blood cardioplegia and terminal warm blood cardioplegic reperfusion ("hot shot") reduce myocardial injury and improve metabolic recovery in hypoxic but not…”
Get full text

Aortic stenosis: diagnosis and management by Zakkar, M, Bryan, A J, Angelini, G D

“…This review describes the causes, pathophysiology, presentation, and treatment of aortic stenosis. References…”
Get full text

Gene transfer of tissue inhibitor of metalloproteinase-2 inhibits metalloproteinase activity and neointima formation in human saphenous veins by GEORGE, S. J, BAKER, A. H, ANGELINI, G. D, NEWBY, A. C

“…Metalloproteinases (MMPs) are implicated in neointima formation and hence vein graft failure. Gene transfer to elevate local levels of tissue inhibitor of…”
Get full text

Folic acid administration reduces neointimal thickening, augments neo-vasa vasorum formation and reduces oxidative stress in saphenous vein grafts from pigs used as a model of diabetes by Bloor, J., Shukla, N., Smith, F. C. T., Angelini, G. D., Jeremy, J. Y.

“…Aims/hypothesis There is evidence that plasma homocysteine augments vein graft failure and that it augments both micro- and macro-angiopathy in patients with…”
Get full text

Adenovirus-mediated gene transfer of the human TIMP-1 gene inhibits smooth muscle cell migration and neointimal formation in human saphenous vein by George, S J, Johnson, J L, Angelini, G D, Newby, A C, Baker, A H

“…Neointimal formation involving smooth muscle cell (SMC) migration and proliferation is a common feature of atherosclerosis, restenosis after angioplasty, and…”
Get more information

Wild-type p53 gene transfer inhibits neointima formation in human saphenous vein by modulation of smooth muscle cell migration and induction of apoptosis by GEORGE, S. J, ANGELINI, G. D, CAPOGROSSI, M. C, BAKER, A. H

“…Patency of autologous human saphenous vein coronary artery bypass grafts (CABG) is compromised by intimal thickening and superimposed atherosclerosis, caused…”
Get full text

Remote ischaemic preconditioning: is it a flag on the field? by Moscarelli, M, Angelini, GD, Suleiman, S, Fiorentino, F, Punjabi, PP

“…Ischaemic preconditioning is one of several different techniques that have been proposed to render the heart more resistant to ischaemia/reperfusion injuries…”
Get full text

Randomized trial of near-infrared spectroscopy for personalized optimization of cerebral tissue oxygenation during cardiac surgery by Rogers, C.A., Stoica, S., Ellis, L., Stokes, E.A., Wordsworth, S., Dabner, L., Clayton, G., Downes, R., Nicholson, E., Bennett, S., Angelini, G.D., Reeves, B.C., Murphy, G.J.

“…We assessed whether a near-infrared spectroscopy (NIRS)-based algorithm for the personalized optimization of cerebral oxygenation during cardiopulmonary bypass…”
Get full text

Dynamic output and control of the hypothalamic-pituitary-adrenal axis in critical illness and major surgery by Gibbison, B, Angelini, G.D., Lightman, S.L.

“…The hypothalamic-pituitary-adrenal (HPA) axis is a neuro-endocrine system that regulates circulating levels of glucocorticoid hormones. These hormones are…”
Get full text