Search Results - "Angelini, Costanza"
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The p140Cap adaptor protein as a molecular hub to block cancer aggressiveness
Published in Cellular and molecular life sciences : CMLS (01-02-2021)“…The p140Cap adaptor protein is a scaffold molecule encoded by the SRCIN1 gene, which is physiologically expressed in several epithelial tissues and in the…”
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p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response
Published in Nature communications (11-05-2023)“…The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a favorable prognosis. Here we highlight a function of p140Cap in…”
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Human mesenchymal stem cells and derived extracellular vesicles induce regulatory dendritic cells in type 1 diabetic patients
Published in Diabetologia (01-02-2016)Get full text
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The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma
Published in Cell death and differentiation (01-02-2020)“…Neuroblastoma is the most common extra-cranial pediatric solid tumor, responsible for 13–15% of pediatric cancer death. Its intrinsic heterogeneity makes it…”
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Correction to: The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma
Published in Cell death and differentiation (01-04-2020)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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p140Cap Controls Female Fertility in Mice Acting via Glutamatergic Afference on Hypothalamic Gonadotropin-Releasing Hormone Neurons
Published in Frontiers in neuroscience (14-02-2022)“…p140Cap, encoded by the gene ( , is an adaptor/scaffold protein highly expressed in the mouse brain, participating in several pre- and post-synaptic…”
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Direct and Intestinal Epithelial Cell-Mediated Effects of TLR8 Triggering on Human Dendritic Cells, CD14 + CD16 + Monocytes and γδ T Lymphocytes
Published in Frontiers in immunology (22-12-2017)“…Toll-like receptor (TLR)7/8 plays a crucial role in host recognition/response to viruses and its mucosal expression directly correlates with intestinal…”
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Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders
Published in Frontiers in molecular neuroscience (30-06-2017)“…Altered synaptic function has been associated with neurological and psychiatric conditions including intellectual disability, schizophrenia and autism spectrum…”
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Dissecting the Shared and Context-Dependent Pathways Mediated by the p140Cap Adaptor Protein in Cancer and in Neurons
Published in Frontiers in cell and developmental biology (15-10-2019)“…The p140Cap adaptor protein is a scaffold molecule physiologically expressed in few epithelial tissues, such as the mammary gland, and in differentiated…”
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Human mesenchymal stem cells and derived extracellular vesicles induce regulatory dendritic cells in type 1 diabetic patients
Published in Diabetologia (01-02-2016)“…Aims/hypothesis Mesenchymal stem cells (MSCs) can exert an immunosuppressive effect on any component of the immune system, including dendritic cells (DCs), by…”
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Exploring chitosan-shelled nanobubbles to improve HER2 + immunotherapy via dendritic cell targeting
Published in Drug delivery and translational research (01-08-2022)“…Immunotherapy is a valuable approach to cancer treatment as it is able to activate the immune system. However, the curative methods currently in clinical…”
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p140Cap Regulates the Composition and Localization of the NMDAR Complex in Synaptic Lipid Rafts
Published in The Journal of neuroscience (21-09-2022)“…The NMDARs are key players in both physiological and pathologic synaptic plasticity because of their involvement in many aspects of neuronal transmission as…”
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p140Cap Regulates GABAergic Synaptogenesis and Development of Hippocampal Inhibitory Circuits
Published in Cerebral cortex (New York, N.Y. 1991) (01-01-2019)“…Abstract The neuronal scaffold protein p140Cap was investigated during hippocampal network formation. p140Cap is present in presynaptic GABAergic terminals and…”
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The N-terminal domain of the adaptor protein p140Cap interacts with Tiam1 and controls Tiam1/Rac1 axis
Published in American journal of cancer research (01-01-2020)“…The p140Cap adaptor protein, encoded by the gene, negatively controls tumor progression, as demonstrated in the subgroup of -amplified breast cancers and in…”
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