Search Results - "Angeli, Andrea"

Five-Membered Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors by Angeli, Andrea, Paoletti, Niccolò, Supuran, Claudiu T

“…The development of heterocyclic derivatives has progressed considerably over the past decades, and many new carbonic anhydrase inhibitors (CAIs) fall into this…”
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Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications by Angeli, Andrea, Supuran, Claudiu T.

“…Click chemistry reactions constitute an important and relatively new approach in the medicinal chemistry toolbox and offer substantial advantages to medicinal…”
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Pharmacological Inhibition of CA-IX Impairs Tumor Cell Proliferation, Migration and Invasiveness by Ciccone, Valerio, Filippelli, Arianna, Angeli, Andrea, Supuran, Claudiu T, Morbidelli, Lucia

“…Carbonic anhydrase IX (CA-IX) plays a pivotal role in regulation of pH in tumor milieu catalyzing carbonic acid formation by hydrating CO . An acidification of…”
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Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase by Nocentini, Alessio, Angeli, Andrea, Carta, Fabrizio, Winum, Jean-Yves, Zalubovskis, Raivis, Carradori, Simone, Capasso, Clemente, Donald, William A., Supuran, Claudiu T.

“…Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) generally by coordinating to the active site metal ion. Cyanate was reported as…”
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Carbonic Anhydrases: Versatile and Useful Biocatalysts in Chemistry and Biochemistry by Andrea Angeli, Fabrizio Carta, Claudiu T. Supuran

“…Metalloenzymes such as the carbonic anhydrases (CAs, EC 4.2.1.1) possess highly specialized active sites that promote fast reaction rates and high substrate…”
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Selenolesterase enzyme activity of carbonic anhydrases by Angeli, Andrea, Carta, Fabrizio, Donnini, Selene, Capperucci, Antonella, Ferraroni, Marta, Tanini, Damiano, Supuran, Claudiu T

“…Carbonic anhydrases (CAs, E.C. 4.2.1.1) are metalloenzymes expressed on a variety of cell types. Their overexpression leads to serious pathologies, including…”
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Chagas Disease: Perspectives on the Past and Present and Challenges in Drug Discovery by Mansoldo, Felipe Raposo Passos, Carta, Fabrizio, Angeli, Andrea, Cardoso, Veronica da Silva, Supuran, Claudiu T, Vermelho, Alane Beatriz

“…Chagas disease still has no effective treatment option for all of its phases despite being discovered more than 100 years ago. The development of commercial…”
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Selective Inhibition of Helicobacter pylori Carbonic Anhydrases by Carvacrol and Thymol Could Impair Biofilm Production and the Release of Outer Membrane Vesicles by Grande, Rossella, Carradori, Simone, Puca, Valentina, Vitale, Irene, Angeli, Andrea, Nocentini, Alessio, Bonardi, Alessandro, Gratteri, Paola, Lanuti, Paola, Bologna, Giuseppina, Simeone, Pasquale, Capasso, Clemente, De Luca, Viviana, Supuran, Claudiu T

“…, a Gram-negative neutrophilic pathogen, is the cause of chronic gastritis, peptic ulcers, and gastric cancer in humans. Current therapeutic regimens suffer…”
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New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors by Gul, Halise Inci, Yamali, Cem, Sakagami, Hiroshi, Angeli, Andrea, Leitans, Janis, Kazaks, Andris, Tars, Kaspars, Ozgun, Dilan Ozmen, Supuran, Claudiu T.

“…[Display omitted] •The compounds 34 and 36 can be considered as leader anticancer compounds.•The compound 36 was a selective inhibitor of hCA XII…”
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Selenium-analogs based on natural sources as cancer-associated carbonic anhydrase isoforms IX and XII inhibitors by Astrain-Redin, Nora, Paoletti, Niccolò, Plano, Daniel, Bonardi, Alessandro, Gratteri, Paola, Angeli, Andrea, Sanmartin, Carmen, Supuran, Claudiu T.

“…In the relentless search for new cancer treatments, organoselenium compounds, and carbonic anhydrase (CA) inhibitors have emerged as promising drug candidates…”
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1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy by Kaproń, Barbara, Czarnomysy, Robert, Wysokiński, Mariusz, Andrys, Rudolf, Musilek, Kamil, Angeli, Andrea, Supuran, Claudiu T., Plech, Tomasz

“…There are numerous studies supporting the contribution of oxidative stress to the pathogenesis of epilepsy. Prolonged oxidative stress is associated with the…”
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Ureidobenzenesulfonamides as Selective Carbonic Anhydrase I, IX, and XII Inhibitors by Denner, Toni C, Angeli, Andrea, Ferraroni, Marta, Supuran, Claudiu T, Csuk, René

“…Sulfonamides remain an important class of drugs, especially because of their inhibitory effects on carbonic anhydrases. Herein, we have synthesized several…”
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Investigation on Hydrazonobenzenesulfonamides as Human Carbonic Anhydrase I, II, IX and XII Inhibitors by Moi, Davide, Vittorio, Serena, Angeli, Andrea, Balboni, Gianfranco, Supuran, Claudiu T, Onnis, Valentina

“…A small series of hydrazonobenzenesulfonamides was designed, synthesized and studied for their human carbonic anhydrase (hCA) inhibitory activity. The…”
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Diversely N-substituted benzenesulfonamides dissimilarly bind to human carbonic anhydrases: crystallographic investigations of N-nitrosulfonamides by Angeli, Andrea, Ferraroni, Marta, Bonardi, Alessandro, Supuran, Claudiu T., Nocentini, Alessio

“…Carbonic anhydrases (CAs) are a zinc metalloenzymes that catalyse the reversible hydration of carbon dioxide to bicarbonate and proton, pivotal for a wide…”
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4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies by Nada, Hossam, Elkamhawy, Ahmed, Abdellattif, Magda H., Angeli, Andrea, Lee, Chang Hoon, Supuran, Claudiu T., Lee, Kyeong

“…Human carbonic anhydrase inhibitors (hCAIs) are a key therapeutic class with a multitude of novel applications such as anticonvulsants, topically acting…”
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Generation and characterisation of an Arabidopsis thaliana f3h/fls1/ans triple mutant that accumulates eriodictyol derivatives by Schilbert, Hanna Marie, Busche, Mareike, Sáez, Vania, Angeli, Andrea, Weisshaar, Bernd, Martens, Stefan, Stracke, Ralf

“…Flavonoids are plant specialised metabolites, which derive from phenylalanine and acetate metabolism. They possess a variety of beneficial characteristics for…”
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Carbonic Anhydrase Inhibition with Sulfonamides Incorporating Pyrazole- and Pyridazinecarboxamide Moieties Provides Examples of Isoform-Selective Inhibitors by Angeli, Andrea, Kartsev, Victor, Petrou, Anthi, Pinteala, Mariana, Brovarets, Volodymyr, Vydzhak, Roman, Panchishin, Svitlana, Geronikaki, Athina, Supuran, Claudiu T

“…A series of benzenesulfonamides incorporating pyrazole- and pyridazinecarboxamides decorated with several bulky moieties has been obtained by original…”
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Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII by Gumus, Arzu, Bozdag, Murat, Akdemir, Atilla, Angeli, Andrea, Selleri, Silvia, Carta, Fabrizio, Supuran, Claudiu T.

“…A novel series of thiosemicarbazide-substituted coumarins was synthesized and the inhibitory effects against four physiologically relevant carbonic anhydrase…”
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Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment by Angeli, Andrea, Carta, Fabrizio, Nocentini, Alessio, Winum, Jean-Yves, Zalubovskis, Raivis, Akdemir, Atilla, Onnis, Valentina, Eldehna, Wagdy M., Capasso, Clemente, Simone, Giuseppina De, Monti, Simona Maria, Carradori, Simone, Donald, William A., Dedhar, Shoukat, Supuran, Claudiu T.

“…The tumor microenvironment is crucial for the growth of cancer cells, triggering particular biochemical and physiological changes, which frequently influence…”
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Amine- and Amino Acid-Based Compounds as Carbonic Anhydrase Activators by Angeli, Andrea, Berrino, Emanuela, Carradori, Simone, Supuran, Claudiu T, Cirri, Marzia, Carta, Fabrizio, Costantino, Gabriele

“…After being rather neglected as a research field in the past, carbonic anhydrase activators (CAAs) were undoubtedly demonstrated to be useful in diverse…”
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