Search Results - "Angel, Peggi"

On the Cutting Edge of Translational Research by Angel, Peggi M

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Review of the ASMS 2021 Fall Workshop on MALDI Imaging Mass Spectrometry by Angel, Peggi M

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Matrix-Assisted Laser Desorption Ionization Imaging Mass Spectrometry: In Situ Molecular Mapping by Angel, Peggi M, Caprioli, Richard M

“…Matrix-assisted laser desorption ionization imaging mass spectrometry (IMS) is a relatively new imaging modality that allows mapping of a wide range of…”
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Applications and continued evolution of glycan imaging mass spectrometry by McDowell, Colin T., Lu, Xiaowei, Mehta, Anand S., Angel, Peggi M., Drake, Richard R.

“…Glycosylation is an important posttranslational modifier of proteins and lipid conjugates critical for the stability and function of these macromolecules…”
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Multiplexed imaging mass spectrometry of the extracellular matrix using serial enzyme digests from formalin-fixed paraffin-embedded tissue sections by Clift, Cassandra L., Drake, Richard R., Mehta, Anand, Angel, Peggi M.

“…We report a multiplexed imaging mass spectrometry method which spatially localizes and selectively accesses the extracellular matrix on formalin-fixed…”
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Enhanced Sensitivity for High Spatial Resolution Lipid Analysis by Negative Ion Mode Matrix Assisted Laser Desorption Ionization Imaging Mass Spectrometry by Angel, Peggi M., Spraggins, Jeffrey M., Baldwin, H. Scott, Caprioli, Richard

“…We have achieved enhanced lipid imaging to a ∼10 μm spatial resolution using negative ion mode matrix assisted laser desorption ionization (MALDI) imaging mass…”
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Imaging Mass Spectrometry and Lectin Analysis of N-Linked Glycans in Carbohydrate Antigen–Defined Pancreatic Cancer Tissues by McDowell, Colin T., Klamer, Zachary, Hall, Johnathan, West, Connor A., Wisniewski, Luke, Powers, Thomas W., Angel, Peggi M., Mehta, Anand S., Lewin, David N., Haab, Brian B., Drake, Richard R.

“…The early detection of pancreatic ductal adenocarcinoma (PDAC) is a complex clinical obstacle yet is key to improving the overall likelihood of patient…”
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Mass Spectrometry Imaging of N‑Linked Glycans in a Formalin-Fixed Paraffin-Embedded Human Prostate by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization by Pace, Crystal L, Angel, Peggi M, Drake, Richard R, Muddiman, David C

“…N-Linked glycans are structurally diverse polysaccharides that represent significant biological relevance due to their involvement in disease progression and…”
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MALDI Imaging Mass Spectrometry of N-glycans and Tryptic Peptides from the Same Formalin-Fixed, Paraffin-Embedded Tissue Section by Angel, Peggi M, Mehta, Anand, Norris-Caneda, Kim, Drake, Richard R

“…Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a unique and well developed tool for probing the protein content of…”
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Mapping Extracellular Matrix Proteins in Formalin-Fixed, Paraffin-Embedded Tissues by MALDI Imaging Mass Spectrometry by Angel, Peggi M, Comte-Walters, Susana, Ball, Lauren E, Talbot, Kacey, Mehta, Anand, Brockbank, Kelvin G.M, Drake, Richard R

“…Collagens and elastin form the fundamental framework of all tissues and organs, and their expression and post-translational processing are tightly regulated in…”
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N‑Linked Glycan Branching and Fucosylation Are Increased Directly in Hcc Tissue As Determined through in Situ Glycan Imaging by West, Connor A, Wang, Mengjun, Herrera, Harmin, Liang, Hongyan, Black, Alyson, Angel, Peggi M, Drake, Richard R, Mehta, Anand S

“…Hepatocellular carcinoma (HCC) remains as the fifth most common cancer in the world and accounts for more than 700,000 deaths annually. Changes in serum…”
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Stromal Signaling in Cancer by Angel, Peggi, Ostrowski, Michael

“…Stromal Signaling in Cancer, Volume 154 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting…”
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Molecular analysis of the extracellular microenvironment: from form to function by Macdonald, Jade K., Mehta, Anand S., Drake, Richard R., Angel, Peggi M.

“…The extracellular matrix (ECM) proteome represents an important component of the tissue microenvironment that controls chemical flux and induces cell signaling…”
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Evaluation of antibody-based single cell type imaging techniques coupled to multiplexed imaging of N-glycans and collagen peptides by matrix-assisted laser desorption/ionization mass spectrometry imaging by Dunne, Jaclyn, Griner, Jake, Romeo, Martin, Macdonald, Jade, Krieg, Carsten, Lim, Mark, Yagnik, Gargey, Rothschild, Kenneth J., Drake, Richard R., Mehta, Anand S., Angel, Peggi M.

“…The integration of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) with single cell spatial omics methods allows for a…”
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Unbiased Metabolomic Investigation of Alzheimer’s Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism by Paglia, Giuseppe, Stocchero, Matteo, Cacciatore, Stefano, Lai, Steven, Angel, Peggi, Alam, Mohammad Tauqeer, Keller, Markus, Ralser, Markus, Astarita, Giuseppe

“…Alzheimer’s disease (AD) is the most common cause of adult dementia. Yet the complete set of molecular changes accompanying this inexorable, neurodegenerative…”
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Imaging of N‑Linked Glycans in Biological Tissue Sections Using Nanospray Desorption Electrospray Ionization (nano-DESI) Mass Spectrometry by Weigand, Miranda R., Moore, Alyssa M., Hu, Hang, Angel, Peggi M., Drake, Richard R., Laskin, Julia

“…N-linked glycans are complex biomolecules vital to cellular functions that have been linked to a wide range of pathological conditions. Mass spectrometry…”
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Defining the human kidney N‐glycome in normal and cancer tissues using MALDI imaging mass spectrometry by Drake, Richard R., McDowell, Colin, West, Connor, David, Fred, Powers, Thomas W., Nowling, Tamara, Bruner, Evelyn, Mehta, Anand S., Angel, Peggi M., Marlow, Laura A., Tun, Han W., Copland, John A.

“…Clear‐cell renal cell carcinoma (ccRCC) presents challenges to clinical management because of late‐stage detection, treatment resistance, and frequent disease…”
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Rapid N‑Glycan Profiling of Serum and Plasma by a Novel Slide-Based Imaging Mass Spectrometry Workflow by Blaschke, Calvin R. K, Black, Alyson P, Mehta, Anand S, Angel, Peggi M, Drake, Richard R

“…Changes in the levels and compositions of N-glycans released from serum and plasma glycoproteins have been assessed in many diseases across many large clinical…”
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Ion Mobility-Derived Collision Cross Section As an Additional Measure for Lipid Fingerprinting and Identification by Paglia, Giuseppe, Angel, Peggi, Williams, Jonathan P, Richardson, Keith, Olivos, Hernando J, Thompson, J. Will, Menikarachchi, Lochana, Lai, Steven, Walsh, Callee, Moseley, Arthur, Plumb, Robert S, Grant, David F, Palsson, Bernhard O, Langridge, James, Geromanos, Scott, Astarita, Giuseppe

“…Despite recent advances in analytical and computational chemistry, lipid identification remains a significant challenge in lipidomics. Ion-mobility…”
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Novel Combined Enzymatic Approach to Analyze Nonsialylated N‑Linked Glycans through MALDI Imaging Mass Spectrometry by DelaCourt, Andrew T., Liang, Hongyan, Drake, Richard R., Angel, Peggi M., Mehta, Anand S.

“…Alterations to N-glycan expression are relevant to the progression of various diseases, particularly cancer. In many cases, specific N-glycan structural…”
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