Search Results - "Angagaw, Minilik"

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors by Morris, Erick J, Jha, Sharda, Restaino, Clifford R, Dayananth, Priya, Zhu, Hugh, Cooper, Alan, Carr, Donna, Deng, Yongi, Jin, Weihong, Black, Stuart, Long, Brian, Liu, Jenny, Dinunzio, Edward, Windsor, William, Zhang, Rumin, Zhao, Shuxia, Angagaw, Minilik H, Pinheiro, Elaine M, Desai, Jagdish, Xiao, Li, Shipps, Gerald, Hruza, Alan, Wang, James, Kelly, Joe, Paliwal, Sunil, Gao, Xiaolei, Babu, Boga Sobhana, Zhu, Liang, Daublain, Pierre, Zhang, Ling, Lutterbach, Bart A, Pelletier, Marc R, Philippar, Ulrike, Siliphaivanh, Phieng, Witter, David, Kirschmeier, Paul, Bishop, W Robert, Hicklin, Daniel, Gilliland, D Gary, Jayaraman, Lata, Zawel, Leigh, Fawell, Stephen, Samatar, Ahmed A

“…The high frequency of activating RAS or BRAF mutations in cancer provides strong rationale for targeting the mitogen-activated protein kinase (MAPK) pathway…”
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MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis by Booher, Robert N, Hatch, Harold, Dolinski, Brian M, Nguyen, Thi, Harmonay, Lauren, Al-Assaad, Ali-Samer, Ayers, Mark, Nebozhyn, Michael, Loboda, Andrey, Hirsch, Heather A, Zhang, Theresa, Shi, Bin, Merkel, Carrie E, Angagaw, Minilik H, Wang, Yaolin, Long, Brian J, Lennon, Xianlu Q, Miselis, Nathan, Pucci, Vincenzo, Monahan, James W, Lee, Junghoon, Kondic, Anna Georgieva, Im, Eun Kyung, Mauro, David, Blanchard, Rebecca, Gilliland, Gary, Fawell, Stephen E, Zawel, Leigh, Schuller, Alwin G, Strack, Peter

“…Dinaciclib is a potent CDK1, 2, 5 and 9 inhibitor being developed for the treatment of cancer. Additional understanding of antitumor mechanisms and…”
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Characterization of murine CEACAM1 in vivo reveals low expression on CD8 + T cells and no tumor growth modulating activity by anti-CEACAM1 mAb CC1 by McLeod, Robbie L, Angagaw, Minilik H, Baral, Toya Nath, Liu, Liming, Moniz, Raymond Joseph, Laskey, Jason, Hsieh, SuChun, Lee, Mike, Han, Jin-Hwan, Issafras, Hassan, Javaid, Sarah, Loboda, Andrey, Sadekova, Svetlana, O'Connor, Joann A, Tse, Archie, Punnonen, Juha

“…Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) has been reported to mediate both tumorigenic and anti-tumor effects . Blockade of the…”
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A Quantitative Volumetric Micro-Computed Tomography Method to Analyze Lung Tumors in Genetically Engineered Mouse Models by Haines, Brian B., Bettano, Kimberly A., Chenard, Melissa, Sevilla, Raquel S., Ware, Christopher, Angagaw, Minilik H., Winkelmann, Christopher T., Tong, Christopher, Reilly, John F., Sur, Cyrille, Zhang, Weisheng

“…Two genetically engineered, conditional mouse models of lung tumor formation, K-rasLSL-G12D and K-rasLSL-G12D/p53LSL-R270H, are commonly used to model human…”
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PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models by Ellwood-Yen, Katharine, Keilhack, Heike, Kunii, Kaiko, Dolinski, Brian, Connor, Yamicia, Hu, Kun, Nagashima, Kumiko, O'Hare, Erin, Erkul, Yusuf, Di Bacco, Alessandra, Gargano, Diana, Shomer, Nirah H, Angagaw, Minilik, Leccese, Erica, Andrade, Paula, Hurd, Melissa, Shin, Myung K, Vogt, Thomas F, Northrup, Alan, Bobkova, Ekaterina V, Kasibhatla, Shailaja, Bronson, Roderick T, Scott, Martin L, Draetta, Giulio, Richon, Victoria, Kohl, Nancy, Blume-Jensen, Peter, Andersen, Jannik N, Kraus, Manfred

“…PDK1 activates AKT suggesting that PDK1 inhibition might suppress tumor development. However, while PDK1 has been investigated intensively as an oncology…”
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Purine derivatives as potent γ-secretase modulators by Rivkin, Alexey, Ahearn, Sean P., Chichetti, Stephanie M., Hamblett, Christopher L., Garcia, Yudith, Martinez, Michelle, Hubbs, Jed L., Reutershan, Michael H., Daniels, Matthew H., Siliphaivanh, Phieng, Otte, Karin M., Li, Chaomin, Rosenau, Andrew, Surdi, Laura M., Jung, Joon, Hughes, Bethany L., Crispino, Jamie L., Nikov, George N., Middleton, Richard E., Moxham, Christopher M., Szewczak, Alexander A., Shah, Sanjiv, Moy, Lily Y., Kenific, Candia M., Tanga, Flobert, Cruz, Jonathan C., Andrade, Paula, Angagaw, Minilik H., Shomer, Nirah H., Miller, Thomas, Munoz, Benito, Shearman, Mark S.

“…The development of a novel series of purines as γ-secretase modulators for potential use in the treatment of Alzheimer’s disease is disclosed herein…”
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Splenectomy normalizes hematocrit in murine polycythemia vera by Mo, Jan-Rung, Mathur, Anjili, Angagaw, Minilik, Zhao, Shuxia, Wang, Yuxun, Gargano, Diana, DiBacco, Alessandra, Bachman, Eric S

“…Splenic enlargement (splenomegaly) develops in numerous disease states, although a specific pathogenic role for the spleen has rarely been described. In…”
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Transferring Luminex® cytokine assays to a wall-less plate technology: Validation and comparison study with plasma and cell culture supernatants by Versteeg, Leroy, Le Guezennec, Xavier, Zhan, Bin, Liu, Zhuyun, Angagaw, Minilik, Woodhouse, Janice D., Biswas, Subhabrata, Beaumier, Coreen M.

“…Luminex® technology provides a powerful methodology for multiplex cytokine detection but remains constrained by high costs and a minimum of 25–50μL sample…”
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Transferring Luminex registered cytokine assays to a wall-less plate technology: Validation and comparison study with plasma and cell culture supernatants by Versteeg, Leroy, Le Guezennec, Xavier, Zhan, Bin, Liu, Zhuyun, Angagaw, Minilik, Woodhouse, Janice D, Biswas, Subhabrata, Beaumier, Coreen M

“…Luminex registered technology provides a powerful methodology for multiplex cytokine detection but remains constrained by high costs and a minimum of 25-50 mu…”
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Inhibition of Tumor Growth Progression by Antiandrogens and mTOR Inhibitor in a Pten-Deficient Mouse Model of Prostate Cancer by WEISHENG ZHANG, ZHU, Joe, SUR, Cyrille, MAJUMDER, Pradip K, EFFERSON, Clay L, WARE, Chris, TAMMAM, Jennifer, ANGAGAW, Minilik, LASKEY, Jason, BETTANO, Kimberly A, KASIBHATLA, Shailaja, REILLY, John F

“…Androgen receptors have been shown to play a critical role in prostate cancer. We used ultrasound imaging techniques to track tumor response to antiandrogen…”
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Abstract 699: Optimized dosing strategies resulting in prolonged pathway inhibition enhance dinaciclib anti-tumor activity in preclinical xenograft models by Schuller, Alwin, Booher, Robert, Cadzow, Louise, Angagaw, Minilik, Harmonay, Lauren, Qu, Xianlu, Miselis, Nathan, Pucci, Vincenzo, Ayers, Mark, Graef, Thorsten, Im, Ellie, Blanchard, Rebecca, Long, Brian, Zawel, Leigh, strack, peter

“…Abstract Dinaciclib is a novel CDK1, 2, 5, and 9 inhibitor currently in clinical development for CLL. Preclinical studies indicate that dinaciclib may have…”
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Abstract 3394: A gamma secretase inhibitor reduces large neurosphere formation in glioma cell lines which correlates with decreased tumorigenicity by Lopez-Molina, Javier, Rao, Sudhir, Angagaw, Minilik, Wexler, Roseanne, Cristescu, Razvan, Demuth, Tim, Sun, Hong, Toniatti, Carlo

“…Abstract Notch signaling regulates many aspects of development, cell fate and tissue renewal. Recent work has implicated the pathway in regulating and…”
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Fluorinated piperidine acetic acids as γ-secretase modulators by Stanton, Matthew G., Hubbs, Jed, Sloman, David, Hamblett, Christopher, Andrade, Paula, Angagaw, Minilik, Bi, Grace, Black, Regina M., Crispino, Jamie, Cruz, Jonathan C., Fan, Eric, Farris, Georgia, Hughes, Bethany L., Kenific, Candia M., Middleton, Richard E., Nikov, George, Sajonz, Peter, Shah, Sanjiv, Shomer, Nirah, Szewczak, Alexander A., Tanga, Flobert, Tudge, Matthew T., Shearman, Mark, Munoz, Benito

“…The discovery and optimization of a novel class of difluoropiperidine acetic acid γ-secretase modulators is described. These compounds selectivity inhibit the…”
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Abstract 698: MCL1 dependent cells are sensitive to the CDK inhibitor Dinaciclib by Hatch, Harold, Booher, Robert, Perera, Samanthi, Nguyen, Thi, Dolinski, Brian, Al-Assaad, Samer, Harmonay, Lauren, Schuller, Alwin, Angagaw, Minilik, Long, Brian, Qu, Xianlu, Miselis, Nathan, Ayers, Mark, Nebozhyn, Michael, Hirsch, Heather, Greenawalt, Danielle, Loboda, Andrey, Graef, Thorseten, Im, Ellie, Blanchard, Rebecca, Zawel, Leigh, Strack, Peter

“…Abstract Dinaciclib is a potent inhibitor of cyclin dependent kinases (CDKs) 1, 2, 5, and 9 and is currently in Phase 3 for the treatment of refractory chronic…”
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Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors by Zhang, Weisheng, Haines, Brian B, Efferson, Clay, Zhu, Joe, Ware, Chris, Kunii, Kaiko, Tammam, Jennifer, Angagaw, Minilik, Hinton, Marlene C, Keilhack, Heike, Paweletz, Cloud P, Zhang, Theresa, Winter, Chris, Sathyanarayanan, Sriram, Cheng, Jonathan, Zawel, Leigh, Fawell, Stephen, Gilliland, Gary, Majumder, Pradip K

“…Abstract Activation of the phosphoinositide 3-kinase pathway is commonly observed in human prostate cancer. Loss of function of phosphatase and tensin homolog…”
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Abstract LB-284: Combination of antiandrogens and PI3-kinase pathway inhibitors in a model of androgen-dependent prostate cancer by Efferson, Clay, Zhu, Joe, Ware, Chris, Tammam, Jennifer, Angagaw, Minilik, Reilly, John F., Sur, Cyrille, Clark, Edwin, Winter, Chris, Zhang, Weisheng, Majumder, Pradip K.

“…Abstract Prostate cancer is the third most common cause of cancer-related deaths in men and is most prevalent in developed countries. The androgen signaling…”
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I PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models by ELLWOOD-YEN, Katharine, KEILHACK, Heike, GARGANO, Diana, SHOMER, Nirah H, ANGAGAW, Minilik, LECCESE, Erica, ANDRADE, Paula, HURD, Melissa, SHIN, Myung K, VOGT, Thomas F, NORTHRUP, Alan, BOBKOVA, Ekaterina V, KUNII, Kaiko, KASIBHATLA, Shailaja, BRONSON, Roderick T, SCOTT, Martin L, DRAETTA, Giulio, RICHON, Victoria, KOHL, Nancy, BLUME-JENSEN, Peter, ANDERSEN, Jannik N, KRAUS, Manfred, DOLINSKI, Brian, CONNOR, Yamicia, KUN HU, NAGASHIMA, Kumiko, O'HARE, Erin, ERKUL, Yusuf, DI BACCO, Alessandra

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Fluorinated piperidine acetic acids as g-secretase modulators by Stanton, Matthew G, Hubbs, Jed, Sloman, David, Hamblett, Christopher, Andrade, Paula, Angagaw, Minilik, Bi, Grace, Black, Regina M, Crispino, Jamie, Cruz, Jonathan C, Fan, Eric, Farris, Georgia, Hughes, Bethany L, Kenific, Candia M, Middleton, Richard E, Nikov, George, Sajonz, Peter, Shah, Sanjiv, Shomer, Nirah, Szewczak, Alexander A, Tanga, Flobert, Tudge, Matthew T, Shearman, Mark, Munoz, Benito

“…We report herein a novel series of difluoropiperidine acetic acids as modulators of g-secretase. Synthesis of 2-aryl-3,3-difluoropiperidine analogs was…”
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Purine derivatives as potent g-secretase modulators by Rivkin, Alexey, Ahearn, Sean P, Chichetti, Stephanie M, Hamblett, Christopher L, Garcia, Yudith, Martinez, Michelle, Hubbs, Jed L, Reutershan, Michael H, Daniels, Matthew H, Siliphaivanh, Phieng, Otte, Karin M, Li, Chaomin, Rosenau, Andrew, Surdi, Laura M, Jung, Joon, Hughes, Bethany L, Crispino, Jamie L, Nikov, George N, Middleton, Richard E, Moxham, Christopher M, Szewczak, Alexander A, Shah, Sanjiv, Moy, Lily Y, Kenific, Candia M, Tanga, Flobert, Cruz, Jonathan C, Andrade, Paula, Angagaw, Minilik H, Shomer, Nirah H, Miller, Thomas, Munoz, Benito, Shearman, Mark S

“…The development of a novel series of purines as g-secretase modulators for potential use in the treatment of Alzheimer's disease is disclosed herein…”
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Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors1 by Zhang, Weisheng, Haines, Brian B, Efferson, Clay, Zhu, Joe, Ware, Chris, Kunii, Kaiko, Tammam, Jennifer, Angagaw, Minilik, Hinton, Marlene C, Keilhack, Heike, Paweletz, Cloud P, Zhang, Theresa, Winter, Chris, Sathyanarayanan, Sriram, Cheng, Jonathan, Zawel, Leigh, Fawell, Stephen, Gilliland, Gary, Majumder, Pradip K

“…Activation of the phosphoinositide 3-kinase pathway is commonly observed in human prostate cancer. Loss of function of phosphatase and tensin homolog (PTEN) is…”
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