Search Results - "Ang, Kenny K.H."

A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit by De Muylder, Geraldine, Ang, Kenny K H, Chen, Steven, Arkin, Michelle R, Engel, Juan C, McKerrow, James H

“…The ability to screen compounds in a high-throughput manner is essential in the process of small molecule drug discovery. Critical to the success of screening…”
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Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51 by Gunatilleke, Shamila S, Calvet, Claudia M, Johnston, Jonathan B, Chen, Chiung-Kuang, Erenburg, Grigori, Gut, Jiri, Engel, Juan C, Ang, Kenny K H, Mulvaney, Joseph, Chen, Steven, Arkin, Michelle R, McKerrow, James H, Podust, Larissa M

“…Chagas Disease, a WHO- and NIH-designated neglected tropical disease, is endemic in Latin America and an emerging infection in North America and Europe as a…”
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Mining a cathepsin inhibitor library for new antiparasitic drug leads by Ang, Kenny K H, Ratnam, Joseline, Gut, Jiri, Legac, Jennifer, Hansell, Elizabeth, Mackey, Zachary B, Skrzypczynska, Katarzyna M, Debnath, Anjan, Engel, Juan C, Rosenthal, Philip J, McKerrow, James H, Arkin, Michelle R, Renslo, Adam R

“…The targeting of parasite cysteine proteases with small molecules is emerging as a possible approach to treat tropical parasitic diseases such as sleeping…”
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An image-based assay for high throughput screening of Giardia lamblia by Gut, Jiri, Ang, Kenny K.H., Legac, Jennifer, Arkin, Michelle R., Rosenthal, Philip J., McKerrow, James H.

“…Giardia lamblia is a protozoan parasite that causes widespread gastrointestinal illness. Drugs to treat giardiasis are limited, but efforts to discover new…”
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UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area by Arkin, Michelle R, Ang, Kenny K H, Chen, Steven, Davies, Julia, Merron, Connie, Tang, Yinyan, Wilson, Christopher G M, Renslo, Adam R

“…The Small Molecule Discovery Center (SMDC) at the University of California, San Francisco, works collaboratively with the scientific community to solve…”
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Pharmacological brake-release of mRNA translation enhances cognitive memory by Sidrauski, Carmela, Acosta-Alvear, Diego, Khoutorsky, Arkady, Vedantham, Punitha, Hearn, Brian R, Li, Han, Gamache, Karine, Gallagher, Ciara M, Ang, Kenny K-H, Wilson, Chris, Okreglak, Voytek, Ashkenazi, Avi, Hann, Byron, Nader, Karim, Arkin, Michelle R, Renslo, Adam R, Sonenberg, Nahum, Walter, Peter

“…Phosphorylation of the α-subunit of initiation factor 2 (eIF2) controls protein synthesis by a conserved mechanism. In metazoa, distinct stress conditions…”
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Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi, the Agent of Chagas' Disease by Engel, Juan C, Ang, Kenny K H, Chen, Steven, Arkin, Michelle R, McKerrow, James H, Doyle, Patricia S

“…OA  Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Divergent Modes of Enzyme Inhibition in a Homologous Structure−Activity Series by Ferreira, Rafaela S, Bryant, Clifford, Ang, Kenny K. H, McKerrow, James H, Shoichet, Brian K, Renslo, Adam R

“…A docking screen identified reversible, noncovalent inhibitors (e.g., 1) of the parasite cysteine protease cruzain. Chemical optimization of 1 led to a series…”
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A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver by Suzawa, Miyuki, Miranda, Diego A, Ramos, Karmela A, Ang, Kenny K-H, Faivre, Emily J, Wilson, Christopher G, Caboni, Laura, Arkin, Michelle R, Kim, Yeong-Sang, Fletterick, Robert J, Diaz, Aaron, Schneekloth, John S, Ingraham, Holly A

“…SUMO-modification of nuclear proteins has profound effects on gene expression. However, non-toxic chemical tools that modulate sumoylation in cells are…”
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Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases by Bryant, Clifford, Kerr, Iain D., Debnath, Moumita, Ang, Kenny K.H., Ratnam, Joseline, Ferreira, Rafaela S., Jaishankar, Priyadarshini, Zhao, DongMei, Arkin, Michelle R., McKerrow, James H., Brinen, Linda S., Renslo, Adam R.

“…We describe here the identification of non-peptidic vinylsulfones that inhibit parasite cysteine proteases in vitro and inhibit the growth of Trypanosoma…”
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Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit by Chen, Chiung-Kuang, Doyle, Patricia S, Yermalitskaya, Liudmila V, Mackey, Zachary B, Ang, Kenny K H, McKerrow, James H, Podust, Larissa M

“…The two front-line drugs for chronic Trypanosoma cruzi infections are limited by adverse side-effects and declining efficacy. One potential new target for…”
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In Vivo Antimalarial Activity of the Beta-Carboline Alkaloid Manzamine A by Ang, K K, Holmes, M J, Higa, T, Hamann, M T, Kara, U A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target by Choy, Jonathan W, Bryant, Clifford, Calvet, Claudia M, Doyle, Patricia S, Gunatilleke, Shamila S, Leung, Siegfried S F, Ang, Kenny K H, Chen, Steven, Gut, Jiri, Oses-Prieto, Juan A, Johnston, Jonathan B, Arkin, Michelle R, Burlingame, Alma L, Taunton, Jack, Jacobson, Matthew P, McKerrow, James M, Podust, Larissa M, Renslo, Adam R

“…Inhibition of the Trypanosoma cruzi cysteine protease cruzain has been proposed as a therapeutic approach for the treatment of Chagas' disease. Among the…”
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Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes by Klein, Hannah L, Ang, Kenny K H, Arkin, Michelle R, Beckwitt, Emily C, Chang, Yi-Hsuan, Fan, Jun, Kwon, Youngho, Morten, Michael J, Mukherjee, Sucheta, Pambos, Oliver J, El Sayyed, Hafez, Thrall, Elizabeth S, Vieira-da-Rocha, João P, Wang, Quan, Wang, Shuang, Yeh, Hsin-Yi, Biteen, Julie S, Chi, Peter, Heyer, Wolf-Dietrich, Kapanidis, Achillefs N, Loparo, Joseph J, Strick, Terence R, Sung, Patrick, Van Houten, Bennett, Niu, Hengyao, Rothenberg, Eli

“…Genomes are constantly in flux, undergoing changes due to recombination, repair and mutagenesis. , many of such changes are studies using reporters for…”
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New Antiinfective and Human 5-HT2 Receptor Binding Natural and Semisynthetic Compounds from the Jamaican Sponge Smenospongia aurea by HU, Jin-Feng, SCHETZ, John A., KELLY, Michelle, PENG, Jiang-Nan, ANG, Kenny K. H., FLOTOW, Horst, LEONG, Chung Yan, NG, Siew Bee, BUSS, Antony D., WILKINS, Scott P., HAMANN, Mark T.

“…In addition to the sesquiterpene-phenol aureols (1), 6'-chloroaureol (2), and aureol acetate (3), eight indole alkaloids including the new…”
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A benzopyrroloisoquinoline alkaloid from Ficus fistulosa by Subramaniam, G., Ang, Kenny K.H., Ng, Siewbee, Buss, Antony D., Butler, Mark S.

“…A new benzopyrroloisoquinoline alkaloid, fistulosine ( 1), was isolated from the stem-bark of Ficus fistulosa collected in Singapore. Also isolated were three…”
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