Search Results - "Ang, Jann"

Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2 by Afkhami, Sam, D’Agostino, Michael R., Zhang, Ali, Stacey, Hannah D., Marzok, Art, Kang, Alisha, Singh, Ramandeep, Bavananthasivam, Jegarubee, Ye, Gluke, Luo, Xiangqian, Wang, Fuan, Ang, Jann C., Zganiacz, Anna, Sankar, Uma, Kazhdan, Natallia, Koenig, Joshua F.E., Phelps, Allyssa, Gameiro, Steven F., Tang, Shangguo, Jordana, Manel, Wan, Yonghong, Mossman, Karen L., Jeyanathan, Mangalakumari, Gillgrass, Amy, Medina, Maria Fe C., Smaill, Fiona, Lichty, Brian D., Miller, Matthew S., Xing, Zhou

“…The emerging SARS-CoV-2 variants of concern (VOCs) threaten the effectiveness of current COVID-19 vaccines administered intramuscularly and designed to only…”
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High‐Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild‐Type and B.1.1.7 SARS‐CoV‐2 in Unprocessed Saliva by Zhang, Zijie, Pandey, Richa, Li, Jiuxing, Gu, Jimmy, White, Dawn, Stacey, Hannah D., Ang, Jann C., Steinberg, Catherine‐Jean, Capretta, Alfredo, Filipe, Carlos D. M., Mossman, Karen, Balion, Cynthia, Miller, Matthew S., Salena, Bruno J., Yamamura, Deborah, Soleymani, Leyla, Brennan, John D., Li, Yingfu

“…We report a simple and rapid saliva‐based SARS‐CoV‐2 antigen test that utilizes a newly developed dimeric DNA aptamer, denoted as DSA1N5, that specifically…”
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Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library by Li, Jiuxing, Zhang, Zijie, Gu, Jimmy, Stacey, Hannah D, Ang, Jann C, Capretta, Alfredo, Filipe, Carlos D M, Mossman, Karen L, Balion, Cynthia, Salena, Bruno J, Yamamura, Deborah, Soleymani, Leyla, Miller, Matthew S, Brennan, John D, Li, Yingfu

“…Abstract We performed in vitro selection experiments to identify DNA aptamers for the S1 subunit of the SARS-CoV-2 spike protein (S1 protein). Using a pool of…”
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A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern by Zhang, Zijie, Li, Jiuxing, Gu, Jimmy, Amini, Ryan, Stacey, Hannah D., Ang, Jann C., White, Dawn, Filipe, Carlos D. M., Mossman, Karen, Miller, Matthew S., Salena, Bruno J., Yamamura, Deborah, Sen, Payel, Soleymani, Leyla, Brennan, John D., Li, Yingfu

“…We report on a unique DNA aptamer, denoted MSA52, that displays universally high affinity for the spike proteins of wildtype SARS‐CoV‐2 as well as the Alpha,…”
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IgA potentiates NETosis in response to viral infection by Stacey, Hannah D., Golubeva, Diana, Posca, Alyssa, Ang, Jann C., Novakowski, Kyle E., Zahoor, Muhammad Atif, Kaushic, Charu, Cairns, Ewa, Bowdish, Dawn M. E., Mullarkey, Caitlin E., Miller, Matthew S.

“…IgA is the second most abundant antibody present in circulation and is enriched at mucosal surfaces. As such, IgA plays a key role in protection against a…”
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A liposome-displayed hemagglutinin vaccine platform protects mice and ferrets from heterologous influenza virus challenge by Sia, Zachary R., He, Xuedan, Zhang, Ali, Ang, Jann C., Shao, Shuai, Seffouh, Amal, Huang, Wei-Chiao, D’Agostino, Michael R., Dereshgi, Amir Teimouri, Suryaprakash, Sambhara, Ortega, Joaquin, Andersen, Hanne, Miller, Matthew S., Davidson, Bruce A., Lovell, Jonathan F.

“…Recombinant influenza virus vaccines based on hemagglutinin (HA) hold the potential to accelerate production timelines and improve efficacy relative to…”
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Three on Three: Universal and High-Affinity Molecular Recognition of the Symmetric Homotrimeric Spike Protein of SARS-CoV‑2 with a Symmetric Homotrimeric Aptamer by Li, Jiuxing, Zhang, Zijie, Gu, Jimmy, Amini, Ryan, Mansfield, Alexandria G., Xia, Jianrun, White, Dawn, Stacey, Hannah D., Ang, Jann C., Panesar, Gurpreet, Capretta, Alfredo, Filipe, Carlos D. M., Mossman, Karen, Salena, Bruno J., Gubbay, Jonathan B., Balion, Cynthia, Soleymani, Leyla, Miller, Matthew S., Yamamura, Deborah, Brennan, John D., Li, Yingfu

“…Our previously discovered monomeric aptamer for SARS-CoV-2 (MSA52) possesses a universal affinity for COVID-19 spike protein variants but is ultimately limited…”
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High‐Precision Viral Detection Using Electrochemical Kinetic Profiling of Aptamer‐Antigen Recognition in Clinical Samples and Machine Learning by Sen, Payel, Zhang, Zijie, Sakib, Sadman, Gu, Jimmy, Li, Wantong, Adhikari, Bal Ram, Motsenyat, Ariel, L'Heureux‐Hache, Jonathan, Ang, Jann C., Panesar, Gurpreet, Salena, Bruno J., Yamamura, Debora, Miller, Matthew S., Li, Yingfu, Soleymani, Leyla

“…High‐precision viral detection at point of need with clinical samples plays a pivotal role in the diagnosis of infectious diseases and the control of a global…”
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Immunomodulatory drugs have divergent effects on humoral and cellular immune responses to SARS-CoV-2 vaccination in people living with rheumatoid arthritis by Benoit, Jenna M., Breznik, Jessica A., Ang, Jann C., Bhakta, Hina, Huynh, Angela, Cowbrough, Braeden, Baker, Barbara, Heessels, Lauren, Lodhi, Sumiya, Yan, Elizabeth, Ewusie, Joycelyne, Nazy, Ishac, Bramson, Jonathan, Miller, Matthew S., Bernatsky, Sasha, Larché, Maggie J., Bowdish, Dawn M. E.

“…Understanding the efficacy of SARS-CoV-2 vaccination in people on immunosuppressive drugs, including those with rheumatoid arthritis (RA), is critical for…”
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Cytomegalovirus Seropositivity in Older Adults Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination by Breznik, Jessica A, Huynh, Angela, Zhang, Ali, Bilaver, Lucas, Bhakta, Hina, Stacey, Hannah D, Ang, Jann C, Bramson, Jonathan L, Nazy, Ishac, Miller, Matthew S, Denburg, Judah, Costa, Andrew P, Bowdish, Dawn M E

“…Chronic infection with human CMV may contribute to poor vaccine efficacy in older adults. We assessed the effects of CMV serostatus on Ab quantity and quality,…”
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Characteristics of Anti-SARS-CoV-2 Antibodies in Recovered COVID-19 Subjects by Huynh, Angela, Arnold, Donald M, Smith, James W, Moore, Jane C, Zhang, Ali, Chagla, Zain, Harvey, Bart J, Stacey, Hannah D, Ang, Jann C, Clare, Rumi, Ivetic, Nikola, Chetty, Vasudhevan T, Bowdish, Dawn M E, Miller, Matthew S, Kelton, John G, Nazy, Ishac

“…Coronavirus Disease 2019 (COVID-19) is a global pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While detection of…”
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A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern by Zhang, Zijie, Li, Jiuxing, Gu, Jimmy, Amini, Ryan, Stacey, Hannah D., Ang, Jann C., White, Dawn, Filipe, Carlos D. M., Mossman, Karen, Miller, Matthew S., Salena, Bruno J., Yamamura, Deborah, Sen, Payel, Soleymani, Leyla, Brennan, John D., Li, Yingfu

“…Invited for the cover of this issue are John Brennan, Yingfu Li, and co‐workers at McMaster University. The image depicts MSA52 as a universal DNA aptamer that…”
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Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections by Kennedy, Allison E, Cook, Laura, Breznik, Jessica A, Cowbrough, Braeden, Wallace, Jessica G, Huynh, Angela, Smith, James W, Son, Kiho, Stacey, Hannah, Ang, Jann, McGeer, Allison, Coleman, Brenda L, Larché, Maggie, Larché, Mark, Hambly, Nathan, Nair, Parameswaran, Ask, Kjetil, Miller, Matthew S, Bramson, Jonathan, Levings, Megan K, Nazy, Ishac, Svenningsen, Sarah, Mukherjee, Manali, Bowdish, Dawn M E

“…Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections can…”
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Hemagglutinin stalk-binding antibodies enhance effectiveness of neuraminidase inhibitors against influenza via Fc-dependent effector functions by Zhang, Ali, Chaudhari, Hanu, Agung, Yonathan, D’Agostino, Michael R., Ang, Jann C., Tugg, Yona, Miller, Matthew S.

“…The conserved hemagglutinin stalk domain is an attractive target for broadly effective antibody-based therapeutics and next-generation universal influenza…”
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High‐Precision Viral Detection Using Electrochemical Kinetic Profiling of Aptamer‐Antigen Recognition in Clinical Samples and Machine Learning by Sen, Payel, Zhang, Zijie, Sakib, Sadman, Gu, Jimmy, Li, Wantong, Adhikari, Bal Ram, Motsenyat, Ariel, L'Heureux‐Hache, Jonathan, Ang, Jann C., Panesar, Gurpreet, Salena, Bruno J., Yamamura, Debora, Miller, Matthew S., Li, Yingfu, Soleymani, Leyla

“…High‐precision viral detection at point of need with clinical samples plays a pivotal role in the diagnosis of infectious diseases and the control of a global…”
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Inactivated and live-attenuated seasonal influenza vaccines boost broadly neutralizing antibodies in children by Yegorov, Sergey, Celeste, Daniel B., Gomes, Kimberly Braz, Ang, Jann C., Vandenhof, Colin, Wang, Joanne, Rybkina, Ksenia, Tsui, Vanessa, Stacey, Hannah D., Loeb, Mark, Miller, Matthew S.

“…The induction of broadly neutralizing antibodies (bNAbs) that target the hemagglutinin stalk domain is a promising strategy for the development of “universal”…”
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High‐Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild‐Type and B.1.1.7 SARS‐CoV‐2 in Unprocessed Saliva by Zhang, Zijie, Pandey, Richa, Li, Jiuxing, Gu, Jimmy, White, Dawn, Stacey, Hannah D., Ang, Jann C., Steinberg, Catherine‐Jean, Capretta, Alfredo, Filipe, Carlos D. M., Mossman, Karen, Balion, Cynthia, Miller, Matthew S., Salena, Bruno J., Yamamura, Deborah, Soleymani, Leyla, Brennan, John D., Li, Yingfu

“…We report a simple and rapid saliva‐based SARS‐CoV‐2 antigen test that utilizes a newly developed dimeric DNA aptamer, denoted as DSA1N5, that specifically…”
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Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses by Banerjee, Arinjay, El-Sayes, Nader, Budylowski, Patrick, Jacob, Rajesh Abraham, Richard, Daniel, Maan, Hassaan, Aguiar, Jennifer A., Demian, Wael L., Baid, Kaushal, D'Agostino, Michael R., Ang, Jann Catherine, Murdza, Tetyana, Tremblay, Benjamin J.-M., Afkhami, Sam, Karimzadeh, Mehran, Irving, Aaron T., Yip, Lily, Ostrowski, Mario, Hirota, Jeremy A., Kozak, Robert, Capellini, Terence D., Miller, Matthew S., Wang, Bo, Mubareka, Samira, McGeer, Allison J., McArthur, Andrew G., Doxey, Andrew C., Mossman, Karen

“…Type I interferons (IFNs) are our first line of defense against virus infection. Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit…”
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Comparative Immunogenicity of the 2014-2015 Northern Hemisphere Trivalent IIV and LAIV against Influenza A Viruses in Children by Ang, Jann Catherine, Wang, Biao, Wang, Joanne J F, Zeng, Peter Yu Fan, Krammer, Florian, Ward, Brian J, Russell, Margaret L, Loeb, Mark, Miller, Matthew S

“…Both inactivated influenza vaccines (IIV) and live-attenuated influenza vaccines (LAIV) have been recommended for administration to children. Children are a…”
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Effect of inactivated influenza vaccination on human coronavirus infection: Secondary analysis of a randomized trial in Hutterite colonies by Chen, Andrew T., Stacey, Hannah D., Marzok, Art, Singh, Pardeep, Ang, Jann, Miller, Matthew S., Loeb, Mark

“…Although influenza vaccines provide protection against influenza viruses, concern has been raised that they may increase susceptibility to non-influenza…”
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