Search Results - "Anees, Palapuravan"

Tissue-specific targeting of DNA nanodevices in a multicellular living organism by Chakraborty, Kasturi, Anees, Palapuravan, Surana, Sunaina, Martin, Simona, Aburas, Jihad, Moutel, Sandrine, Perez, Franck, Koushika, Sandhya P, Kratsios, Paschalis, Krishnan, Yamuna

“…Nucleic acid nanodevices present great potential as agents for logic-based therapeutic intervention as well as in basic biology. Often, however, the disease…”
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A Ratiometric Near‐Infrared Fluorogen for the Real Time Visualization of Intracellular Redox Status during Apoptosis by Saranya, Giridharan, Anees, Palapuravan, Joseph, Manu M., Maiti, Kaustabh K., Ajayaghosh, Ayyappanpillai

“…Direct monitoring of apoptotic progression is a major step forward for the early assessment of therapeutic efficacy of certain treatments and the accurate…”
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A protein-dye hybrid system as a narrow range tunable intracellular pH sensor by Anees, Palapuravan, Sudheesh, Karivachery V, Jayamurthy, Purushothaman, Chandrika, Arunkumar R, Omkumar, Ramakrishnapillai V, Ajayaghosh, Ayyappanpillai

“…Accurate monitoring of pH variations inside cells is important for the early diagnosis of diseases such as cancer. Even though a variety of different pH…”
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A Three-Photon Active Organic Fluorophore for Deep Tissue Ratiometric Imaging of Intracellular Divalent Zinc by Philips, Divya Susan, Sreejith, Sivaramapanicker, He, Tingchao, Menon, Nishanth Venugopal, Anees, Palapuravan, Mathew, Jomon, Sajikumar, Sreedharan, Kang, Yuejun, Stuparu, Mihaiela Corina, Sun, Handong, Zhao, Yanli, Ajayaghosh, Ayyappanpillai

“…Deep tissue bioimaging with three‐photon (3P) excitation using near‐infrared (NIR) light in the second IR window (1.0–1.4 μm) could provide high resolution…”
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Quantitative Chemical Imaging of Organelles by Tinker, JoAnn, Anees, Palapuravan, Krishnan, Yamuna

“…Conspectus DNA nanodevices are nanoscale assemblies, formed from a collection of synthetic DNA strands, that may perform artificial functions. The pioneering…”
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Organelle-level precision with next-generation targeting technologies by Saminathan, Anand, Zajac, Matthew, Anees, Palapuravan, Krishnan, Yamuna

“…Intracellular organelles are subsystems within a cell, whose activity and chemical composition reflect the metabolic state of live cells. Alterations in…”
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Self-Assembled Near-Infrared Dye Nanoparticles as a Selective Protein Sensor by Activation of a Dormant Fluorophore by Anees, Palapuravan, Sreejith, Sivaramapanicker, Ajayaghosh, Ayyappanpillai

“…Design of selective sensors for a specific analyte in blood serum, which contains a large number of proteins, small molecules, and ions, is important in…”
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Plasma membrane depolarization reveals endosomal escape incapacity of cell-penetrating peptides by Serulla, Marc, Anees, Palapuravan, Hallaj, Ali, Trofimenko, Evgeniya, Kalia, Tara, Krishnan, Yamuna, Widmann, Christian

“…[Display omitted] Cell-penetrating peptides (CPPs) are short (<30 amino acids), generally cationic, peptides that deliver diverse cargos into cells. CPPs…”
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Quantifying phagosomal HOCl at single immune-cell resolution by Anees, Palapuravan, Zajac, Matthew, Krishnan, Yamuna

“…Neutralization of pathogens by phagocytic immune cells requires the biogenesis of a compartmentalized hotspot of reactive species called the phagosome. One of…”
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Homogenous Scavenging Resolves Low-Purification Yield/Selectivity Caused by Secondary Binding of Protein‑A to Antigen-Binding Antibody Fragments by Anees, Palapuravan, Gauthier, Marc A

“…Antigen-binding fragments of antibodies are biotechnologically useful agents for decorating drug delivery systems, for blocking cell-surface receptors in cell…”
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Detecting organelle-specific activity of potassium channels with a DNA nanodevice by Anees, Palapuravan, Saminathan, Anand, Rozmus, Ezekiel R., Di, Anke, Malik, Asrar B., Delisle, Brian P., Krishnan, Yamuna

“…Cell surface potassium ion (K + ) channels regulate nutrient transport, cell migration and intercellular communication by controlling K + permeability and are…”
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A DNA nanodevice for mapping sodium at single-organelle resolution by Zou, Junyi, Mitra, Koushambi, Anees, Palapuravan, Oettinger, Daphne, Ramirez, Joseph R., Veetil, Aneesh Tazhe, Gupta, Priyanka Dutta, Rao, Rajini, Smith, Jayson J., Kratsios, Paschalis, Krishnan, Yamuna

“…Cellular sodium ion (Na + ) homeostasis is integral to organism physiology. Our current understanding of Na + homeostasis is largely limited to Na + transport…”
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Real time monitoring of aminothiol level in blood using a near-infrared dye assisted deep tissue fluorescence and photoacoustic bimodal imaging by Anees, Palapuravan, Joseph, James, Sreejith, Sivaramapanicker, Menon, Nishanth Venugopal, Kang, Yuejun, Wing-Kwong Yu, Sidney, Ajayaghosh, Ayyappanpillai, Zhao, Yanli

“…The development of molecular probes for the detection and imaging of biological thiols is a major step forward diagnosing various types of diseases. Previously…”
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Passive endocytosis in model protocells by Zhang, Stephanie J, Lowe, Lauren A, Anees, Palapuravan, Krishnan, Yamuna, Fai, Thomas G, Szostak, Jack W, Wang, Anna

“…Semipermeable membranes are a key feature of all living organisms. While specialized membrane transporters in cells can import otherwise impermeable nutrients,…”
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A mechanism of lysosomal calcium entry by Zajac, Matthew, Mukherjee, Sourajit, Anees, Palapuravan, Oettinger, Daphne, Henn, Katharine, Srikumar, Jainaha, Zou, Junyi, Saminathan, Anand, Krishnan, Yamuna

“…Lysosomal calcium (Ca ) release is critical to cell signaling and is mediated by well-known lysosomal Ca channels. Yet, how lysosomes refill their Ca remains…”
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Evidence, Manipulation, and Termination of pH ‘Nanobuffering’ for Quantitative Homogenous Scavenging of Monoclonal Antibodies by Anees, Palapuravan, Zhao, Yi, Greschner, Andrea A, Congdon, Thomas R, de Haan, Hendrick W, Cottenye, Nicolas, Gauthier, Marc A

“…This study demonstrates that pH-responsive polymers have a very high buffering capacity in their immediate vicinity, a phenomenon termed “nanobuffering”. This…”
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A protein–dye hybrid system as a narrow range tunable intracellular pH sensor† †Electronic supplementary information (ESI) available: Figures depicting various photophysical properties, cytotoxicity studies and confocal fluorescence images. See DOI: 10.1039/c6sc02659a Click here for additional data file by Anees, Palapuravan, Sudheesh, Karivachery V., Jayamurthy, Purushothaman, Chandrika, Arunkumar R., Omkumar, Ramakrishnapillai V., Ajayaghosh, Ayyappanpillai

“…A two-component hybrid system consisting of organic dye nanoparticles (ash) and a protein (blue) at different ratios allows for the design of narrow range…”
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Surface core N/S/Se-heteroatom doping of carbon nanodots produces divergent yet consistent optical responses to reactive oxygen species by Geng, Xu, Congdon, Thomas R, Anees, Palapuravan, Greschner, Andrea A, Vetrone, Fiorenzo, Gauthier, Marc A

“…Carbon nanodots (CNDs) have attracted substantial scientific curiosity because of their intriguing stimuli-responsive optical properties. However, one obstacle…”
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Real time monitoring of aminothiol level in blood using a near-infrared dye assisted deep tissue fluorescence and photoacoustic bimodal imagingElectronic supplementary information (ESI) available: Synthetic procedures, detailed characterization data, various photophysical properties and cytotoxicity studies. See DOI: 10.1039/c5sc04986e by Anees, Palapuravan, Joseph, James, Sreejith, Sivaramapanicker, Menon, Nishanth Venugopal, Kang, Yuejun, Wing-Kwong Yu, Sidney, Ajayaghosh, Ayyappanpillai, Zhao, Yanli

“…The development of molecular probes for the detection and imaging of biological thiols is a major step forward diagnosing various types of diseases. Previously…”
Get full text

Real time monitoring of aminothiol level in blood using a near-infrared dye assisted deep tissue fluorescence and photoacoustic bimodal imaging† †Electronic supplementary information (ESI) available: Synthetic procedures, detailed characterization data, various photophysical properties and cytotoxicity studies. See DOI: 10.1039/c5sc04986e by Anees, Palapuravan, Joseph, James, Sreejith, Sivaramapanicker, Menon, Nishanth Venugopal, Kang, Yuejun, Wing-Kwong Yu, Sidney, Ajayaghosh, Ayyappanpillai, Zhao, Yanli

“…Real time monitoring of blood aminothiol level by a near-IR dye assisted fluorescence–photoacoustic bimodal imaging is reported. The development of molecular…”
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