Comparison between the Biofilm Desorption Abilities of T4 and MS2 Coliphages

Biofilms are a collection of microorganisms that adhere to a surface where they continue to grow. Firmly established biofilms can be hazardous to human health. Chemical and biological as well as combination methods are being tested to control biofilms. The elucidation of the biofilm disruption capab...

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Bibliographic Details
Published in:	Applied sciences Vol. 12; no. 12; p. 5957
Main Authors:	Johnson, Tammy R., Andrzejak, Taylor E., Raje, Himanshu S.
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 01-06-2022
Subjects:	Antibiotics biofilm desorption Biofilms Cell adhesion & migration Deoxyribonucleic acid Deprivation Desorption DNA DNA coliphage E coli Microorganisms MS2 phage natural biofilm Nutrients Phages RNA coliphage T4 phage United States > US Spain
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Summary:	Biofilms are a collection of microorganisms that adhere to a surface where they continue to grow. Firmly established biofilms can be hazardous to human health. Chemical and biological as well as combination methods are being tested to control biofilms. The elucidation of the biofilm disruption capabilities of individual bacteriophages has received limited attention. Although the treatment of biofilms with a combination of bacteriophages is effective, the extent to which DNA and RNA coliphages individually desorb biofilms is not well understood. Here, we show that both T4 and MS2 coliphages desorbed natural biofilms. Individual incubations of the equivalent viral load of T4 and MS2 coliphages with natural biofilms resulted in similar desorption of these biofilms. We also note that the nutrient deprivation significantly reduced biofilm growth. However, the biofilm desorption upon nutrient deprivation was similar to that observed with both T4 and MS2 phages.
ISSN:	2076-3417 2076-3417
DOI:	10.3390/app12125957