Search Results - "Andrya J Durr"

Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis by Pinti, Mark V, Fink, Garrett K, Hathaway, Quincy A, Durr, Andrya J, Kunovac, Amina, Hollander, John M

“…Type 2 diabetes mellitus (T2DM) is a systemic disease characterized by hyperglycemia, hyperlipidemia, and organismic insulin resistance. This pathological…”
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Exploring the mitochondrial microRNA import pathway through Polynucleotide Phosphorylase (PNPase) by Shepherd, Danielle L., Hathaway, Quincy A., Pinti, Mark V., Nichols, Cody E., Durr, Andrya J., Sreekumar, Shruthi, Hughes, Kristen M., Stine, Seth M., Martinez, Ivan, Hollander, John M.

“…Cardiovascular disease is the primary cause of mortality for individuals with type 2 diabetes mellitus. During the diabetic condition, cardiovascular…”
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The role of SIRT1 in skeletal muscle function and repair of older mice by Myers, Matthew J., Shepherd, Danielle L., Durr, Andrya J., Stanton, David S., Mohamed, Junaith S., Hollander, John M., Alway, Stephen E.

“…Background Sirtuin 1 (SIRT1) is a NAD+ sensitive deacetylase that has been linked to longevity and has been suggested to confer beneficial effects that counter…”
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Machine learning for spatial stratification of progressive cardiovascular dysfunction in a murine model of type 2 diabetes mellitus by Durr, Andrya J, Korol, Anna S, Hathaway, Quincy A, Kunovac, Amina, Taylor, Andrew D, Rizwan, Saira, Pinti, Mark V, Hollander, John M

“…Speckle tracking echocardiography (STE) has been utilized to evaluate independent spatial alterations in the diabetic heart, but the progressive manifestation…”
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ROS promote epigenetic remodeling and cardiac dysfunction in offspring following maternal engineered nanomaterial (ENM) exposure by Kunovac, Amina, Hathaway, Quincy A, Pinti, Mark V, Goldsmith, William T, Durr, Andrya J, Fink, Garrett K, Nurkiewicz, Timothy R, Hollander, John M

“…Nano-titanium dioxide (nano-TiO ) is amongst the most widely utilized engineered nanomaterials (ENMs). However, little is known regarding the consequences…”
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Machine-learning to stratify diabetic patients using novel cardiac biomarkers and integrative genomics by Hathaway, Quincy A, Roth, Skyler M, Pinti, Mark V, Sprando, Daniel C, Kunovac, Amina, Durr, Andrya J, Cook, Chris C, Fink, Garrett K, Cheuvront, Tristen B, Grossman, Jasmine H, Aljahli, Ghadah A, Taylor, Andrew D, Giromini, Andrew P, Allen, Jessica L, Hollander, John M

“…Diabetes mellitus is a chronic disease that impacts an increasing percentage of people each year. Among its comorbidities, diabetics are two to four times more…”
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Regulating microRNA expression: at the heart of diabetes mellitus and the mitochondrion by Hathaway, Quincy A, Pinti, Mark V, Durr, Andrya J, Waris, Shanawar, Shepherd, Danielle L, Hollander, John M

“…Type 2 diabetes mellitus is a major risk factor for cardiovascular disease and mortality. Uncontrolled type 2 diabetes mellitus results in a systemic milieu of…”
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Manipulation of the miR-378a/mt-ATP6 regulatory axis rescues ATP synthase in the diabetic heart and offers a novel role for lncRNA Kcnq1ot1 by Durr, Andrya J, Hathaway, Quincy A, Kunovac, Amina, Taylor, Andrew D, Pinti, Mark V, Rizwan, Saira, Shepherd, Danielle L, Cook, Chris C, Fink, Garrett K, Hollander, John M

“…Diabetes mellitus has been linked to an increase in mitochondrial microRNA-378a (miR-378a) content. Enhanced miR-378a content has been associated with a…”
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Machine Learning to Identify Regional and Segmental Dysfunction during Type 2 Diabetes Mellitus Progression by Rizwan, Saira, Durr, Andrya J., Korol, Anna, Hathaway, Quincy A., Kunovac Hathaway, Amina, Taylor, Andrew D., Pinti, Mark V., Hollander, John M.

“…Diabetes mellitus results in numerous co‐morbidities, the most serious of which is cardiovascular disease (CVD). Speckle tracking strain‐based echocardiography…”
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Targeting Diabetic Cardiomyopathy: LncRNA Kcnq1ot1 Rescues Mitochondrial ATP Synthase via Sponging of MiR‐378a‐5p by Durr, Andrya J., Hathaway, Quincy A., Kunovac, Amina, Taylor, Andrew D., Rizwan, Saira, Cook, Chris C., Hollander, John M.

“…Diabetes mellitus has been linked to an increase in mitochondrial microRNA‐378a (miR‐378a) content. Twenty‐five‐week‐old miR‐378a knockout Db/Db mice display…”
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N6-methyladenosine (M6A) in fetal offspring modifies mitochondrial gene expression following gestational nano-TiO2 inhalation exposure by Kunovac, Amina, Hathaway, Quincy A, Thapa, Dharendra, Durr, Andrya J, Taylor, Andrew D, Rizwan, Saira, Daud Sharif, Valentine, Stephen J, Hollander, John M

“…N6-methyladenosine (m6A) is the most prominent epitranscriptomic modification to RNA in eukaryotes, but it’s role in adaptive changes within the gestational…”
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N 6 -methyladenosine (M 6 A) in fetal offspring modifies mitochondrial gene expression following gestational nano-TiO 2 inhalation exposure by Kunovac, Amina, Hathaway, Quincy A, Thapa, Dharendra, Durr, Andrya J, Taylor, Andrew D, Rizwan, Saira, Sharif, Daud, Valentine, Stephen J, Hollander, John M

“…N -methyladenosine (m A) is the most prominent epitranscriptomic modification to RNA in eukaryotes, but it's role in adaptive changes within the gestational…”
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Mitochondrial sequencing identifies long noncoding RNA features that promote binding to PNPase by Taylor, Andrew D, Hathaway, Quincy A, Kunovac, Amina, Pinti, Mark V, Newman, Mackenzie S, Cook, Chris C, Cramer, Evan R, Starcovic, Sarah A, Winters, Michael T, Westemeier-Rice, Emily S, Fink, Garrett K, Durr, Andrya J, Rizwan, Saira, Shepherd, Danielle L, Robart, Aaron R, Martinez, Ivan, Hollander, John M

“…Extranuclear localization of long noncoding RNAs (lncRNAs) is poorly understood. Based on machine learning evaluations, we propose a lncRNA-mitochondrial…”
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Mitochondrial proteome disruption in the diabetic heart through targeted epigenetic regulation at the mitochondrial heat shock protein 70 (mtHsp70) nuclear locus by Shepherd, Danielle L., Hathaway, Quincy A., Nichols, Cody E., Durr, Andrya J., Pinti, Mark V., Hughes, Kristen M., Kunovac, Amina, Stine, Seth M., Hollander, John M.

“…>99% of the mitochondrial proteome is nuclear-encoded. The mitochondrion relies on a coordinated multi-complex process for nuclear genome-encoded mitochondrial…”
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Reactive oxygen species damage drives cardiac and mitochondrial dysfunction following acute nano-titanium dioxide inhalation exposure by Nichols, Cody E., Shepherd, Danielle L., Hathaway, Quincy A., Durr, Andrya J., Thapa, Dharendra, Abukabda, Alaeddin, Yi, Jinghai, Nurkiewicz, Timothy R., Hollander, John M.

“…Nanotechnology offers innovation in products from cosmetics to drug delivery, leading to increased engineered nanomaterial (ENM) exposure. Unfortunately,…”
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Enhanced antioxidant capacity prevents epitranscriptomic and cardiac alterations in adult offspring gestationally-exposed to ENM by Kunovac, Amina, Hathaway, Quincy A., Pinti, Mark V., Durr, Andrya J., Taylor, Andrew D., Goldsmith, William T., Garner, Krista L., Nurkiewicz, Timothy R., Hollander, John M.

“…Maternal engineered nanomaterial (ENM) exposure during gestation has been associated with negative long-term effects on cardiovascular health in progeny. Here,…”
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miRNA-378a as a key regulator of cardiovascular health following engineered nanomaterial inhalation exposure by Hathaway, Quincy A., Durr, Andrya J., Shepherd, Danielle L., Pinti, Mark V., Brandebura, Ashley N., Nichols, Cody E., Kunovac, Amina, Goldsmith, William T., Friend, Sherri A., Abukabda, Alaeddin B., Fink, Garrett K., Nurkiewicz, Timothy R., Hollander, John M.

“…Nano-titanium dioxide (nano-TiO 2 ), though one of the most utilized and produced engineered nanomaterials (ENMs), diminishes cardiovascular function through…”
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Evaluation of self-measured blood pressure monitoring in a southern rural West Virginia health system by Durr, Andrya J, Robinson, Craig H, Seabury, Robin A, Calkins, Andrea L, Pollard, Cecil R, N Marcus Thygeson, Lindberg, Curt C, McColley, Jessica M, Baus, Adam D

“…Introduction: At the time of the 2021 Behavioral Risk Factor Surveillance System survey, an estimated 32.3% of adults in the US and nearly half (43.4%, 776…”
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Untangling the roots of the West Virginia opioid crisis: relationships in adolescent pregnancy, drug misuse, and future outcomes by Durr, Andrya J., Critch, Elizabeth A., Fitzgerald, M. Paula, Devlin, Kelly M., Fuller, Kylie A., Renzelli-Cain, Roberta I.

“…West Virginia (WV) is afflicted by high rates of teenage pregnancy and births, opioid usage during pregnancy, and Neonatal Abstinence Syndrome births. Current…”
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Stress Strain Speckle‐Tacking Segmental Analysis Reveals Early Indications of Diastolic Dysfunction in a Type 2 Mouse Model of Diabetes Mellitus by Durr, Andrya J, Hathaway, Quincy A, Pinti, Mark V., Shepherd, Danielle L, Kunovac, Amina, Fink, Garrett K., Hollander, John M

“…Type 2 diabetes mellitus (T2DM) is becoming increasingly common, as there are currently 23.1 million people diagnosed and another 84.1 million adults diagnosed…”
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